Department of Orthopaedic Surgery,
Department of Molecular Pharmacology
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The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: a "bumper-car" model.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2004 | Pubmed ID: 15545600
Fluid shear stress upregulates vascular endothelial growth factor gene expression in osteoblasts.
Annals of the New York Academy of Sciences Nov, 2007 | Pubmed ID: 17646268
Aquaporin-4 water channels in enteric neurons.
Journal of neuroscience research Feb, 2008 | Pubmed ID: 17893913
IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway.
Cell and tissue research Nov, 2008 | Pubmed ID: 18855015
Fluid flow-induced soluble vascular endothelial growth factor isoforms regulate actin adaptation in osteoblasts.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20682775
Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria.
American journal of physiology. Cell physiology Nov, 2010 | Pubmed ID: 20686067
Connexin43 and pannexin1 channels in osteoblasts: who is the "hemichannel"?
The Journal of membrane biology Jul, 2012 | Pubmed ID: 22797941
Gap junctions and Bystander Effects: Good Samaritans and executioners.
Wiley interdisciplinary reviews. Membrane transport and signaling Jan, 2013 | Pubmed ID: 23565352
Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification.
Chemistry & biology Jul, 2013 | Pubmed ID: 23890010
An Integrative Review of Mechanotransduction in Endothelial, Epithelial (Renal) and Dendritic Cells (Osteocytes).
Cellular and molecular bioengineering Dec, 2011 | Pubmed ID: 23976901
Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αVβ3 integrin.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2013 | Pubmed ID: 24324138
Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: implications for Chagas disease.
Microbes and infection Nov, 2014 | Pubmed ID: 25150689
Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling.
PloS one , 2014 | Pubmed ID: 25170954
Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging.
Aging cell Apr, 2015 | Pubmed ID: 25620427
Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Apr, 2016 | Pubmed ID: 26553756
P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes.
PloS one , 2016 | Pubmed ID: 27159053
A new perspective on mechanisms governing skeletal complications in type 1 diabetes.
Annals of the New York Academy of Sciences Nov, 2016 | Pubmed ID: 27571221
Osteocyte calcium signals encode strain magnitude and loading frequency in vivo.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2017 | Pubmed ID: 29078317
Potential role for a specialized β integrin-based structure on osteocyte processes in bone mechanosensation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Feb, 2018 | Pubmed ID: 29087614
Role of pannexin 1 channels in load-induced skeletal response.
Annals of the New York Academy of Sciences Apr, 2019 | Pubmed ID: 29952014
CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.
Annals of the New York Academy of Sciences Apr, 2019 | Pubmed ID: 30891766
Mechanosensitive Vaginal Epithelial Adenosine Triphosphate Release and Pannexin 1 Channels in Healthy, in Type 1 Diabetic, and in Surgically Castrated Female Mice.
The journal of sexual medicine May, 2020 | Pubmed ID: 32241676
Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice.
Frontiers in cellular neuroscience , 2021 | Pubmed ID: 33790744
Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading.
Bone Nov, 2021 | Pubmed ID: 34171514
Karl J. Lewis1,
James F. Boorman-Padgett3,
Macy Castaneda2,
David C. Spray4,
Mia M. Thi5,6,
Mitchell B. Schaffler3
1Meinig School of Biomedical Engineering, Cornell University,
2Sibley School of Mechanical and Aerospace Engineering, Cornell University,
3Department of Biomedical Engineering, The City College of New York,
4Department of Neuroscience, Albert Einstein College of Medicine,
5Department of Orthopaedic Surgery, Albert Einstein College of Medicine,
6Department of Molecular Pharmacology, Albert Einstein College of Medicine
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