Mitchell B. Schaffler

A model for the role of integrins in flow induced mechanotransduction in osteocytes.

Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue.

The dependency of solute diffusion on molecular weight and shape in intact bone.

Cancellous bone adaptation to tibial compression is not sex dependent in growing mice.

Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging.

Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations.

Osteocyte signaling in bone.

Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor.

Osteocytes: master orchestrators of bone.

Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo.

Structural and mechanical repair of diffuse damage in cortical bone in vivo.

Authors response to letter from Plotkin and Bellido.

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.

Bone microdamage, remodeling and bone fragility: how much damage is too much damage?

Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes.

Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs.

Regional differences in oxidative metabolism and mitochondrial activity among cortical bone osteocytes.

Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo.

Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue.

Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling.

Osteocyte calcium signals encode strain magnitude and loading frequency in vivo.

Potential role for a specialized β integrin-based structure on osteocyte processes in bone mechanosensation.

Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model.

CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.

Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels.

A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation.

Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading.

Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation.