detection-of-abnormal-prion-protein-by-immunohistochemistry

Detection of Abnormal Prion Protein by Immunohistochemistry

Abnormal prion proteins (PrPSc) are the disease-associated isoform of cellular prion protein and diagnostic markers of transmissible spongiform ...

UEISPSA, National Institute for Agricultural and Veterinary Research (INIAV), Vairão

Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of infectious, inherited and spontaneous neurodegenerative diseases affecting human and animals. They are caused by the conversion of cellular prion protein (PrP) into a misfolded pathological isoform (PrP or prion- proteinaceous infectious particle) that self-propagates by conformational conversion of PrP. Yet by an unknown mechanism, PrP can fold into different PrP conformers that may result in different prion strains that display specific disease phenotype (incubation time, clinical signs and lesion profile). Although the pathways for neurodegeneration as well as the involvement of brain inflammation in these diseases are not well understood, the spongiform changes, neuronal loss, gliosis and accumulation of PrP are the characteristic neuropathological lesions. Scrapie affecting small ruminants was the first identified TSE and has been considered the archetype of prion diseases, though atypical and new animal prion diseases continue to emerge highlighting the importance to investigate the lesion profile in naturally affected animals. In this report, we review the neuropathology and the neuroinflammation of animal prion diseases in natural hosts from scrapie, going through the zoonotic bovine spongiform encephalopathy (BSE), the chronic wasting disease (CWD) to the newly identified camel prion disease (CPD).

Carla Lima

Pathology Laboratory

UEISPSA, National Institute for Agricultural and Veterinary Research (INIAV), Vairão

Detection of Abnormal Prion Protein by Immunohistochemistry

Carla Lima

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Pathology Laboratory

UEISPSA, National Institute for Agricultural and Veterinary Research (INIAV), Vairão

Detection of Abnormal Prion Protein by Immunohistochemistry

Pathology Laboratory