Jennifer L. Gommerman

Department of Immunology, University of Toronto

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2024

Other Publications

Article	Year
The LIGHT and DARC sides of herpesvirus entry mediator. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16159963	2005
AID mutates a non-immunoglobulin transgene independent of chromosomal position. Molecular immunology\| PubMed ID: 16542725	2007
LIGHT is dispensable for CD4+ and CD8+ T cell and antibody responses to influenza A virus in mice. International immunology\| PubMed ID: 16569673	2006
BAFF induces a hyper-IgA syndrome in the intestinal lamina propria concomitant with IgA deposition in the kidney independent of LIGHT. Cellular immunology\| PubMed ID: 16987502	2006
The lymphotoxin pathway: beyond lymph node development. Immunologic research\| PubMed ID: 17003508	2006
Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. The Journal of experimental medicine\| PubMed ID: 17452522	2007
ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18250437	2008
Nod2-dependent Th2 polarization of antigen-specific immunity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19017983	2008
AID constrains germinal center size by rendering B cells susceptible to apoptosis. Blood\| PubMed ID: 19478044	2009
Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon-beta. Blood\| PubMed ID: 19652204	2009
Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets. The Journal of experimental medicine\| PubMed ID: 19917778	2009
Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20173032	2010
Cytokine/stromal cell networks and lymphoid tissue environments. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 21133813	2011
The lymphotoxin pathway as a novel regulator of dendritic cell function. Advances in experimental medicine and biology\| PubMed ID: 21153340	2011
LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21245292	2011
Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy. The Journal of clinical investigation\| PubMed ID: 21881212	2011
LTβR and CD40: working together in dendritic cells to optimize immune responses. Immunological reviews\| PubMed ID: 22017433	2011
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity\| PubMed ID: 22018469	2011
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature\| PubMed ID: 22158124	2012
Unusual timing of CD127 expression by mouse uterine natural killer cells. Journal of leukocyte biology\| PubMed ID: 22227963	2012
Fine-tuning of dendritic cell biology by the TNF superfamily. Nature reviews. Immunology\| PubMed ID: 22487654	2012
Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response. PloS one\| PubMed ID: 22545114	2012
Lymphotoxin-sensitive microenvironments in homeostasis and inflammation. Frontiers in immunology\| PubMed ID: 22866054	2012
A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22933630	2012
Secondary B cell receptor diversification is necessary for T cell mediated neuro-inflammation during experimental autoimmune encephalomyelitis. PloS one\| PubMed ID: 23613859	2013
The Regulation of Immune Responses by DC Derived Type I IFN. Frontiers in immunology\| PubMed ID: 23626590	2013
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nature immunology\| PubMed ID: 23913046	2013
AID-expressing germinal center B cells cluster normally within lymph node follicles in the absence of FDC-M1+ CD35+ follicular dendritic cells but dissipate prematurely. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24068672	2013
AID and caspase 8 shape the germinal center response through apoptosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24244021	2013
The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity. Cytokine & growth factor reviews\| PubMed ID: 24698108	2014
The 14th International TNF Conference, Québec City, Canada - Des Progrės Récents aux Défis Futurs (Recent Advances toward Future Challenges). Cytokine & growth factor reviews\| PubMed ID: 24698109	2014
HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men. PLoS pathogens\| PubMed ID: 25275513	2014
Re-thinking the functions of IgA(+) plasma cells. Gut microbes\| PubMed ID: 25483334	2014
Asthma, type 1 and type 2 diabetes mellitus, and inflammatory bowel disease amongst South Asian immigrants to Canada and their children: a population-based cohort study. PloS one\| PubMed ID: 25849480	2015
B cells in MS: Why, where and how? Multiple sclerosis and related disorders\| PubMed ID: 25877077	2012
A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26459352	2015
Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Science translational medicine\| PubMed ID: 26491076	2015
Hematopoietic LTβR deficiency results in skewed T cell cytokine profiles during a mucosal viral infection. Journal of leukocyte biology\| PubMed ID: 26657790	2016
Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation. Immunity\| PubMed ID: 26682987	2015
B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation. Frontiers in immunology\| PubMed ID: 26732544	2015
Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis. Frontiers in immunology\| PubMed ID: 26779181	2015
Meningeal Tertiary Lymphoid Tissues and Multiple Sclerosis: A Gathering Place for Diverse Types of Immune Cells during CNS Autoimmunity. Frontiers in immunology\| PubMed ID: 26793195	2015
The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation. Cell reports\| PubMed ID: 27160905	2016
Stromal Cell Niches in the Inflamed Central Nervous System. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28223405	2017
Antibody-Independent Function of Human B Cells Contributes to Antifungal T Cell Responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28275140	2017
Three-Dimensional Imaging of Transparent Tissues via Metal Nanoparticle Labeling. Journal of the American Chemical Society\| PubMed ID: 28641018	2017
The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining. Nature communications\| PubMed ID: 29520062	2018
Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in and Mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29980612	2018
Generational Patterns of Asthma Incidence among Immigrants to Canada over Two Decades. A Population-based Cohort Study. Annals of the American Thoracic Society\| PubMed ID: 30395726	2019
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. Cell\| PubMed ID: 30612739	2019
B-Cell Deficiency Lowers Blood Pressure in Mice. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 30636551	2019
NLRC5 deficiency has a moderate impact on immunodominant CD8 T-cell responses during rotavirus infection of adult mice. Immunology and cell biology\| PubMed ID: 30768806	2019
c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells. Cell reports\| PubMed ID: 31116977	2019
Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry. eLife\| PubMed ID: 31368890	2019
Aged hind-limb clasping experimental autoimmune encephalomyelitis models aspects of the neurodegenerative process seen in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31641069	2019
Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers. Science translational medicine\| PubMed ID: 31723036	2019
Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury. JCI insight\| PubMed ID: 31821174	2020
Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity. Science immunology\| PubMed ID: 31862865	2019
Intestinal protection without T cell help. Nature reviews. Immunology\| PubMed ID: 31996798	2020
Dendritic Cell Subsets in Intestinal Immunity and Inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 32071090	2020
A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI insight\| PubMed ID: 32870820	2020
Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis. Journal of molecular biology\| PubMed ID: 32976908	2021
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Science immunology\| PubMed ID: 33033173	2020
Regulation of neuroinflammation by B cells and plasma cells. Immunological reviews\| PubMed ID: 33107072	2021
The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates. The Journal of biological chemistry\| PubMed ID: 33168630	2020
Gut microbiota-specific IgA B cells traffic to the CNS in active multiple sclerosis. Science immunology\| PubMed ID: 33219152	2020
B cell depletion therapies in autoimmune disease: advances and mechanistic insights. Nature reviews. Drug discovery\| PubMed ID: 33324003	2021
Stromal Cell-Mediated Coordination of Immune Cell Recruitment, Retention, and Function in Brain-Adjacent Regions. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 33397742	2021
An "Outside-In" and "Inside-Out" Consideration of Complement in the Multiple Sclerosis Brain: Lessons From Development and Neurodegenerative Diseases. Frontiers in cellular neuroscience\| PubMed ID: 33488361	2020
The Ins and Outs of Central Nervous System Inflammation-Lessons Learned from Multiple Sclerosis. Annual review of immunology\| PubMed ID: 33524273	2021
A totally OSM gift to astrocytes relieves inflammation. Immunity\| PubMed ID: 33691129	2021
The Impact of Migration on the Gut Metagenome of South Asian Canadians. Gut microbes\| PubMed ID: 33794735	2021
Fantastic IgA plasma cells and where to find them. Immunological reviews\| PubMed ID: 34046908	2021
Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory. Acta neuropathologica\| PubMed ID: 34170374	2021
Queen's Gambit: B Cell to Follicle. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 34321285	2021
CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein-Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Respo... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 34400521	2021
The Impact of IgA and the Microbiota on CNS Disease. Frontiers in immunology\| PubMed ID: 34603329	2021
The microbiome and IgA nephropathy. Seminars in immunopathology\| PubMed ID: 34664087	2021
Persistence of T Cell and Antibody Responses to SARS-CoV-2 Up to 9 Months after Symptom Onset. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 34903642	2022
Accumulation of meningeal lymphocytes correlates with white matter lesion activity in progressive multiple sclerosis. JCI insight\| PubMed ID: 35104246	2022
Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses. JCI insight\| PubMed ID: 35133979	2022
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node. Mucosal immunology\| PubMed ID: 35181738	2022
Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection. Mucosal immunology\| PubMed ID: 35468942	2022
Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation. JCI insight\| PubMed ID: 35536649	2022
Age-related changes in multiple sclerosis and experimental autoimmune encephalomyelitis. Seminars in immunology\| PubMed ID: 35752572	2022
Guardians of the oral and nasopharyngeal galaxy: IgA and protection against SARS-CoV-2 infection. Immunological reviews\| PubMed ID: 35815463	2022
Under the influence: environmental factors as modulators of neuroinflammation through the IL-10/IL-10R axis. Frontiers in immunology\| PubMed ID: 37600781	2023
TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses. bioRxiv : the preprint server for biology\| PubMed ID: 37790513	2023
Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity. Mucosal immunology\| PubMed ID: 38278415	2024
Editorial: Environmental factors in autoimmunity. Frontiers in immunology\| PubMed ID: 38292480	2023