Sergei M. Mirkin

Department of Biology, Tufts University

Research Area

Genetics

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Replication fork stalling at natural impediments. Microbiology and molecular biology reviews : MMBR\| PubMed ID: 17347517	2007
Expandable DNA repeats and human disease. Nature\| PubMed ID: 17581576	2007
Discovery of alternative DNA structures: a heroic decade (1979-1989). Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17981612	2008
Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18632578	2008
A tribute to Evgenii V. Ananiev, 1947-2008. PLoS genetics\| PubMed ID: 18769503	2008
Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair. The EMBO journal\| PubMed ID: 18833189	2008
Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility. Nature structural & molecular biology\| PubMed ID: 19136957	2009
Human mutation rate associated with DNA replication timing. Nature genetics\| PubMed ID: 19287383	2009
Checkpoint responses to unusual structures formed by DNA repeats. Molecular carcinogenesis\| PubMed ID: 19306277	2009
Large-scale expansions of Friedreich's ataxia GAA repeats in yeast. Molecular cell\| PubMed ID: 19595718	2009
Mechanisms and implications of transcription blockage by guanine-rich DNA sequences. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20616059	2010
Getting to the core of repeat expansions by cell reprogramming. Cell stem cell\| PubMed ID: 21040891	2010
Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae. PLoS genetics\| PubMed ID: 21249181	2011
Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21282659	2011
Overcoming natural replication barriers: differential helicase requirements. Nucleic acids research\| PubMed ID: 21984413	2012
Effects of Friedreich's ataxia GAA repeats on DNA replication in mammalian cells. Nucleic acids research\| PubMed ID: 22262734	2012
A Renaissance man: in memoriam of Jon Widom (1955-2011). Journal of biomolecular structure & dynamics\| PubMed ID: 22783898	2011
Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells. Molecular cell\| PubMed ID: 22959270	2012
Role of DNA polymerases in repeat-mediated genome instability. Cell reports\| PubMed ID: 23142667	2012
Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks. Nucleic acids research\| PubMed ID: 23275544	2013
DNA replication: driving past four-stranded snags. Nature\| PubMed ID: 23657255	2013
The balancing act of DNA repeat expansions. Current opinion in genetics & development\| PubMed ID: 23725800	2013
Genome rearrangements caused by interstitial telomeric sequences in yeast. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24191060	2013
To switch or not to switch: at the origin of repeat expansion disease. Molecular cell\| PubMed ID: 24411078	2014
Coupling transcriptional state to large-scale repeat expansions in yeast. Cell reports\| PubMed ID: 25464841	2014
The hidden side of unstable DNA repeats: Mutagenesis at a distance. DNA repair\| PubMed ID: 25956860	2015
Transcription blockage by stable H-DNA analogs in vitro. Nucleic acids research\| PubMed ID: 26101261	2015
Putting the Brakes on Huntington Disease in a Mouse Experimental Model. PLoS genetics\| PubMed ID: 26247607	2015
Expansion of Interstitial Telomeric Sequences in Yeast. Cell reports\| PubMed ID: 26586439	2015
The role of break-induced replication in large-scale expansions of (CAG)/(CTG) repeats. Nature structural & molecular biology\| PubMed ID: 27918542	2017
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nature communications\| PubMed ID: 28653660	2017
Precarious maintenance of simple DNA repeats in eukaryotes. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 28703879	2017
A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA) Repeats Associated with Friedreich's Ataxia. Cell reports\| PubMed ID: 28877480	2017
Quantitative Analysis of the Rates for Repeat-Mediated Genome Instability in a Yeast Experimental System. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29043640	2018
Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair. Genome research\| PubMed ID: 29113982	2017
RNA-DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication. Nucleic acids research\| PubMed ID: 29447396	2018
Cis- and Trans-Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics. Trends in genetics : TIG\| PubMed ID: 29567336	2018
Mechanisms of genetic instability caused by (CGG) repeats in an experimental mammalian system. Nature structural & molecular biology\| PubMed ID: 30061600	2018
Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function. Nucleic acids research\| PubMed ID: 30476303	2019
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways. Microbial cell (Graz, Austria)\| PubMed ID: 30652105	2019
At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences. Genes\| PubMed ID: 30764567	2019
Experimental System to Study Instability of (CGG) Repeats in Cultured Mammalian Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31586346	2020
Large-scale contractions of Friedreich's ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31911468	2020
On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability. The Journal of biological chemistry\| PubMed ID: 32060097	2020
Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33495349	2021
Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast. Genetics\| PubMed ID: 34849883	2021
Characteristics and possible mechanisms of formation of microinversions distinguishing human and chimpanzee genomes. Scientific reports\| PubMed ID: 35022450	2022
Partners in crime: Tbf1 and Vid22 promote expansions of long human telomeric repeats at an interstitial chromosome position in yeast. PNAS nexus\| PubMed ID: 35832866	2022
Replication dependent and independent mechanisms of GAA repeat instability. DNA repair\| PubMed ID: 35952488	2022
S1-END-seq reveals DNA secondary structures in human cells. Molecular cell\| PubMed ID: 36075220	2022
Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements. PLoS genetics\| PubMed ID: 36701275	2023
Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers. Nucleic acids research\| PubMed ID: 37216608	2023
Massive contractions of Myotonic Dystrophy Type 2-associated CCTG tetranucleotide repeats occur via double strand break repair with distinct requirements for helicases. bioRxiv : the preprint server for biology\| PubMed ID: 37461657	2023
Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures. bioRxiv : the preprint server for biology\| PubMed ID: 37546920	2023
Detection of alternative DNA structures and its implications for human disease. Molecular cell\| PubMed ID: 37863029	2023
Massive contractions of myotonic dystrophy type 2-associated CCTG tetranucleotide repeats occur via double-strand break repair with distinct requirements for DNA helicases. G3 (Bethesda, Md.)\| PubMed ID: 37950892	2024
Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic acids research\| PubMed ID: 38381906	2024