Sergei M. Mirkin

Replication fork stalling at natural impediments.

Expandable DNA repeats and human disease.

Discovery of alternative DNA structures: a heroic decade (1979-1989).

Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins.

A tribute to Evgenii V. Ananiev, 1947-2008.

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.

Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility.

Human mutation rate associated with DNA replication timing.

Checkpoint responses to unusual structures formed by DNA repeats.

Large-scale expansions of Friedreich's ataxia GAA repeats in yeast.

Mechanisms and implications of transcription blockage by guanine-rich DNA sequences.

Getting to the core of repeat expansions by cell reprogramming.

Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae.

Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast.

Overcoming natural replication barriers: differential helicase requirements.

Effects of Friedreich's ataxia GAA repeats on DNA replication in mammalian cells.

A Renaissance man: in memoriam of Jon Widom (1955-2011).

Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells.

Role of DNA polymerases in repeat-mediated genome instability.

Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.

DNA replication: driving past four-stranded snags.

The balancing act of DNA repeat expansions.

Genome rearrangements caused by interstitial telomeric sequences in yeast.

To switch or not to switch: at the origin of repeat expansion disease.

Coupling transcriptional state to large-scale repeat expansions in yeast.

The hidden side of unstable DNA repeats: Mutagenesis at a distance.

Transcription blockage by stable H-DNA analogs in vitro.

Putting the Brakes on Huntington Disease in a Mouse Experimental Model.

Expansion of Interstitial Telomeric Sequences in Yeast.

The role of break-induced replication in large-scale expansions of (CAG)/(CTG) repeats.

Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.

Precarious maintenance of simple DNA repeats in eukaryotes.

A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA) Repeats Associated with Friedreich's Ataxia.

Quantitative Analysis of the Rates for Repeat-Mediated Genome Instability in a Yeast Experimental System.

Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair.

RNA-DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication.

Cis- and Trans-Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics.

Mechanisms of genetic instability caused by (CGG) repeats in an experimental mammalian system.

Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function.

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.

At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences.

Experimental System to Study Instability of (CGG) Repeats in Cultured Mammalian Cells.

Large-scale contractions of Friedreich's ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability.

On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.

Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging.

Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast.

Characteristics and possible mechanisms of formation of microinversions distinguishing human and chimpanzee genomes.

Partners in crime: Tbf1 and Vid22 promote expansions of long human telomeric repeats at an interstitial chromosome position in yeast.

Replication dependent and independent mechanisms of GAA repeat instability.

S1-END-seq reveals DNA secondary structures in human cells.

Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements.

Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers.

Massive contractions of Myotonic Dystrophy Type 2-associated CCTG tetranucleotide repeats occur via double strand break repair with distinct requirements for helicases.

Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures.

Detection of alternative DNA structures and its implications for human disease.

Massive contractions of myotonic dystrophy type 2-associated CCTG tetranucleotide repeats occur via double-strand break repair with distinct requirements for DNA helicases.

Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures.