Department of Immunology and Biotherapy,
National Clinical Research Center for Cancer,
Tianjin's Clinical Research Center for Cancer,
Key Laboratory of Cancer Immunology and Biotherapy,
Key Laboratory of Cancer Prevention and Therapy,
Department of Immunology and Biotherapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Immunology and Biotherapy, Key Laboratory of Cancer Prevention and Therapy
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Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells.
Journal of experimental & clinical cancer research : CR Sep, 2011 | Pubmed ID: 21917155
Enhanced activation of human dendritic cells by silencing SOCS1 and activating TLRs simultaneously.
Cancer immunology, immunotherapy : CII Oct, 2012 | Pubmed ID: 22366886
Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2013 | Pubmed ID: 23440412
Can the dual-functional capability of CIK cells be used to improve antitumor effects?
Cellular immunology Jan, 2014 | Pubmed ID: 24355711
Maintenance therapy with autologous cytokine-induced killer cells in patients with advanced epithelial ovarian cancer after first-line treatment.
Journal of immunotherapy (Hagerstown, Md. : 1997) , 2014 | Pubmed ID: 24509174
Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma.
International journal of oncology , 2015 | Pubmed ID: 25901533
High-mobility group nucleosome-binding protein 1 is a novel clinical biomarker in non-small cell lung cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Dec, 2015 | Pubmed ID: 26113410
Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis.
Cancer biology & medicine Jun, 2015 | Pubmed ID: 26175928
IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review).
International journal of oncology Jan, 2016 | Pubmed ID: 26548401
Human umbilical cord mesenchymal stem cells delivering sTRAIL home to lung cancer mediated by MCP-1/CCR2 axis and exhibit antitumor effects.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Jun, 2016 | Pubmed ID: 26733169
Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer.
Oncotarget Jun, 2016 | Pubmed ID: 27223258
Profiling the dynamic expression of checkpoint molecules on cytokine-induced killer cells from non-small-cell lung cancer patients.
Oncotarget Jul, 2016 | Pubmed ID: 27283895
Identification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma.
Oncotarget Dec, 2016 | Pubmed ID: 27835574
Suppression of T cells by myeloid-derived suppressor cells in cancer.
Human immunology Feb, 2017 | Pubmed ID: 27939507
Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment.
Frontiers in immunology , 2017 | Pubmed ID: 28228755
Expression of GARP Is Increased in Tumor-Infiltrating Regulatory T Cells and Is Correlated to Clinicopathology of Lung Cancer Patients.
Frontiers in immunology , 2017 | Pubmed ID: 28261204
Cytokine-Induced Killer Cells Modulates Resistance to Cisplatin in the A549/DDP Cell Line.
Journal of Cancer , 2017 | Pubmed ID: 29158802
Herceptin Enhances the Antitumor Effect of Natural Killer Cells on Breast Cancer Cells Expressing Human Epidermal Growth Factor Receptor-2.
Frontiers in immunology , 2017 | Pubmed ID: 29163501
Interleukin-6 -Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer.
Frontiers in immunology , 2017 | Pubmed ID: 29326716
A novel MDSC-induced PD-1PD-L1 B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties.
Oncoimmunology , 2018 | Pubmed ID: 29632731
Neurotensin/IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of Tumor-Associated macrophages and epithelial-mesenchymal transition of hepatocellular carcinoma cells.
Oncoimmunology , 2018 | Pubmed ID: 29900041
SOCS3 Suppression Promoted the Recruitment of CD11bGr-1F4/80MHCII Early-Stage Myeloid-Derived Suppressor Cells and Accelerated Interleukin-6-Related Tumor Invasion Affecting Myeloid Differentiation in Breast Cancer.
Frontiers in immunology , 2018 | Pubmed ID: 30083161
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.
The Journal of experimental medicine Mar, 2019 | Pubmed ID: 30733283
Memory stem T cells generated by Wnt signaling from blood of human renal clear cell carcinoma patients.
Cancer biology & medicine Feb, 2019 | Pubmed ID: 31119051
Cryoablation inhibition of distant untreated tumors (abscopal effect) is immune mediated.
Oncotarget Jun, 2019 | Pubmed ID: 31289616
Macrophages-induced long noncoding RNA H19 up-regulation triggers and activates the miR-193b/MAPK1 axis and promotes cell aggressiveness in hepatocellular carcinoma.
Cancer letters Jan, 2020 | Pubmed ID: 31705929
Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer.
Oncogene Jun, 2020 | Pubmed ID: 32398867
Expression level of PD-L1 is involved in ALDH1A1-mediated poor prognosis in patients with head and neck squamous cell carcinoma.
Pathology, research and practice Sep, 2020 | Pubmed ID: 32825960
Morphine-3-glucuronide upregulates PD-L1 expression TLR4 and promotes the immune escape of non-small cell lung cancer.
Cancer biology & medicine Feb, 2021 | Pubmed ID: 33628591
Lung cancer-associated mesenchymal stem cells promote tumor metastasis and tumorigenesis by induction of epithelial-mesenchymal transition and stem-like reprogram.
Aging Mar, 2021 | Pubmed ID: 33744858
Single-Cell Sequencing Reveals the Transcriptome and TCR Characteristics of pTregs and Expanded iTregs.
Frontiers in immunology , 2021 | Pubmed ID: 33868236
Myeloid-derived suppressor cells regulate the immunosuppressive functions of PD-1PD-L1 Bregs through PD-L1/PI3K/AKT/NF-κB axis in breast cancer.
Cell death & disease May, 2021 | Pubmed ID: 33967272
Molecular subtypes based on CNVs related gene signatures identify candidate prognostic biomarkers in lung adenocarcinoma.
Neoplasia (New York, N.Y.) Jul, 2021 | Pubmed ID: 34139453
The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma.
Cancer biology & medicine Aug, 2021 | Pubmed ID: 34459571
EZH2 identifies the precursors of human natural killer cells with trained immunity.
Cancer biology & medicine Sep, 2021 | Pubmed ID: 34553850
Downregulation of PD-L1 and HLA-I in non-small cell lung cancer with ALK fusion.
Thoracic cancer Apr, 2022 | Pubmed ID: 35253386
CD4 T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer.
Cell death & disease May, 2022 | Pubmed ID: 35523765
Trained Immunity of IL-12-, IL-15-, and IL-18-Induced CD+CD+ NKT-Like Cells.
Journal of oncology , 2022 | Pubmed ID: 35783158
Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC).
Cell death & disease Jul, 2022 | Pubmed ID: 35831283
Rational pemetrexed combined with CIK therapy plus anti-PD-1 mAbs administration sequence will effectively promote the efficacy of CIK therapy in non-small cell lung cancer.
Cancer gene therapy Feb, 2023 | Pubmed ID: 36352092
SOCS3 deficiency-dependent autophagy repression promotes the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway.
Journal of leukocyte biology May, 2023 | Pubmed ID: 36808484
[Study on the Biological Function of Abemecilib in Inhibiting the Proliferation, Invasion and Migration of Small Cell Lung Cancer with High c-Myc Expression].
Zhongguo fei ai za zhi = Chinese journal of lung cancer Feb, 2023 | Pubmed ID: 36872049
DC101, an anti-VEGFR2 agent, promotes high-endothelial venule formation and immune infiltration versus SAR131675 and fruquintinib.
Biochemical and biophysical research communications Jun, 2023 | Pubmed ID: 37084488
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer.
Technology in cancer research & treatment , 2023 | Pubmed ID: 37728201
Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4 T cells through regulating type 2 conventional dendritic cells.
Theranostics , 2023 | Pubmed ID: 37771774
Single-cell transcriptomics reveals tumor-infiltrating B cell function after neoadjuvant pembrolizumab and chemotherapy in non-small cell lung cancer.
Journal of leukocyte biology Sep, 2024 | Pubmed ID: 37931147
Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway.
Clinical and translational medicine Nov, 2023 | Pubmed ID: 37965796
The spatial landscape of T cells in the microenvironment of stage III lung adenocarcinoma.
The Journal of pathology Apr, 2024 | Pubmed ID: 38361487
Anlotinib and anti-PD-1 mAbs perfected CIK cell therapy for lung adenocarcinoma in preclinical trials.
Journal of leukocyte biology Sep, 2024 | Pubmed ID: 38373017
Effects of immunogenic cell death-inducing chemotherapeutics on the immune cell activation and tertiary lymphoid structure formation in melanoma.
Frontiers in immunology , 2024 | Pubmed ID: 38384466
PGAM1 suppression remodels the tumor microenvironment in triple-negative breast cancer and synergizes with anti-PD-1 immunotherapy.
Journal of leukocyte biology Sep, 2024 | Pubmed ID: 38478709
Intratumor tertiary lymphatic structure evaluation predicts the prognosis and immunotherapy response of patients with colorectal cancer.
Frontiers in immunology , 2024 | Pubmed ID: 38500886
Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages.
Cancer gene therapy Jul, 2024 | Pubmed ID: 38750301
Targeted sequencing of DNA/RNA combined with radiomics predicts lymph node metastasis of papillary thyroid carcinoma.
Cancer imaging : the official publication of the International Cancer Imaging Society Jun, 2024 | Pubmed ID: 38886866
Corrigendum: Intratumor tertiary lymphatic structure evaluation predicts the prognosis and immunotherapy response of patients with colorectal cancer.
Frontiers in immunology , 2024 | Pubmed ID: 38947311
Establishment of an animal model of immune-related adverse events induced by immune checkpoint inhibitors.
Cancer medicine Jul, 2024 | Pubmed ID: 39001676
Novel FABP4C1q macrophages enhance antitumor immunity and associated with response to neoadjuvant pembrolizumab and chemotherapy in NSCLC via AMPK/JAK/STAT axis.
Cell death & disease Oct, 2024 | Pubmed ID: 39353883
A prospective study of neoadjuvant pembrolizumab plus chemotherapy for resectable esophageal squamous cell carcinoma: The Keystone-001 trial.
Cancer cell Oct, 2024 | Pubmed ID: 39406186
Xiangqin Zhao1,
Xinbo Gao1,
Wenwen Yu2,
Yi Lu1,
Xuesong Li1,
Lu Tan3,
Xiubao Ren2,
Yifei Wang1,
Weijie Song4,
Jihui Hao1,
Ying Ma1
1Department of Pancreatic Cancer, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital,
2Department of Immunology and Biotherapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Immunology and Biotherapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital,
3Research Core Facility, School of Basic Medical Sciences, Tianjin Medical University,
4Department of Public Laboratory, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital
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