Department of Pancreatic Cancer,
National Clinical Research Center for Cancer,
Tianjin's Clinical Research Center for Cancer,
Tianjin Key Laboratory of Digestive Cancer,
Key Laboratory of Cancer Prevention and Therapy,
Department of Pancreatic Cancer, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy
Jing Hao is a post-doctoral fellow at Cancer Biology Department of Lerner Institute in Cleveland Clinic, USA. She studied Clinical Medicine in China and graduated in 1997 with a MD from Xiangya medical school in Changsha, Hunan Province, China. She was enrolled as a Ph.D. candidate in Toxicology program at Rutgers University in New Jersey USA at 2003. She finished her dissertation on esophageal adenocarcinoma chemoprevention study in 2008 and obtained her Ph.D. later the same year. As a post-doctoral fellow she was previously trained in NCI-Frederick and the George Washington University.
Jing Hao is interested in explore the molecular events in carcinogenesis, therapy resistance and translate the basic research of cancer into clinically relevant therapeutic measures.
Tumor rupture predicts early metastasis and poor prognosis in stage III soft tissue sarcomas.
World journal of surgery May, 2011 | Pubmed ID: 21331475
Polymorphisms in the hypoxia-inducible factor-1α gene confer susceptibility to pancreatic cancer.
Cancer biology & therapy Sep, 2011 | Pubmed ID: 21709439
Regional intra-arterial vs. systemic chemotherapy for advanced pancreatic cancer: a systematic review and meta-analysis of randomized controlled trials.
PloS one , 2012 | Pubmed ID: 22815840
Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene.
PloS one , 2012 | Pubmed ID: 22952674
The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma.
Journal of cellular biochemistry Nov, 2013 | Pubmed ID: 23857671
Contrast enhanced ultrasonography prediction of cystic renal mass in comparison to histopathology.
Clinical hemorheology and microcirculation , 2014 | Pubmed ID: 24165574
The hypoxia-inducible factor-1 regulates the microRNA185 expression through binding to hypoxia response elements sequence 2.
Medical oncology (Northwood, London, England) Dec, 2013 | Pubmed ID: 24198204
Clinical and Prognostic Significance of Coagulation Assays in Pancreatic Cancer Patients With Absence of Venous Thromboembolism.
American journal of clinical oncology Dec, 2015 | Pubmed ID: 24401666
Prostate-specific membrane antigen as a marker of pancreatic cancer cells.
Medical oncology (Northwood, London, England) Mar, 2014 | Pubmed ID: 24477651
Resection or cryosurgery relates with pancreatic tumor type: primary pancreatic cancer with previous non-pancreatic cancer or secondary metastatic cancer within the pancreas.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] , 2014 | Pubmed ID: 24555980
Hypoxia-inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-bundling protein fascin.
Cancer research May, 2014 | Pubmed ID: 24599125
CypA, a gene downstream of HIF-1α, promotes the development of PDAC.
PloS one , 2014 | Pubmed ID: 24662981
[Effects of dioscin on apoptosis in pancreatic cancer MiaPaCa-2 cells and its mechanism].
Zhonghua zhong liu za zhi [Chinese journal of oncology] Jan, 2014 | Pubmed ID: 24685079
Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection.
Carcinogenesis Oct, 2014 | Pubmed ID: 25086759
Pancreaticoduodenectomy and pancreaticoduodenectomy combined with superior mesenteric-portal vein resection for elderly cancer patients.
Hepatobiliary & pancreatic diseases international : HBPD INT Aug, 2014 | Pubmed ID: 25100129
The clinical significance and regulation mechanism of hypoxia-inducible factor-1 and miR-191 expression in pancreatic cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Nov, 2014 | Pubmed ID: 25119596
Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells.
Cancer letters Nov, 2014 | Pubmed ID: 25130171
LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer.
Cancer research Jan, 2015 | Pubmed ID: 25385028
Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma.
Oncotarget Feb, 2015 | Pubmed ID: 25544770
Zinc-triggered hydrogelation of self-assembled small molecules to inhibit bacterial growth.
Scientific reports Jan, 2015 | Pubmed ID: 25583430
Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer.
Biomaterials Apr, 2015 | Pubmed ID: 25678112
Wnt2 protein plays a role in the progression of pancreatic cancer promoted by pancreatic stellate cells.
Medical oncology (Northwood, London, England) Apr, 2015 | Pubmed ID: 25731618
Nanospheres of doxorubicin as cross-linkers for a supramolecular hydrogelation.
Scientific reports Mar, 2015 | Pubmed ID: 25739554
SCF, regulated by HIF-1α, promotes pancreatic ductal adenocarcinoma cell progression.
PloS one , 2015 | Pubmed ID: 25799412
Exploring the Molecular Mechanism and Biomakers of Liver Cancer Based on Gene Expression Microarray.
Pathology oncology research : POR Sep, 2015 | Pubmed ID: 25907256
Should a standard lymphadenectomy during pancreatoduodenectomy exclude para-aortic lymph nodes for all cases of resectable pancreatic head cancer? A consensus statement by the Chinese Study Group for Pancreatic Cancer (CSPAC).
International journal of oncology Oct, 2015 | Pubmed ID: 26314752
Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma.
Oncotarget Sep, 2015 | Pubmed ID: 26315113
XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma.
Cancer science Dec, 2015 | Pubmed ID: 26383967
HIF-1 is a critical target of pancreatic cancer.
Oncoimmunology Sep, 2015 | Pubmed ID: 26405594
The clinical utility of CA125/MUC16 in pancreatic cancer: A consensus of diagnostic, prognostic and predictive updates by the Chinese Study Group for Pancreatic Cancer (CSPAC).
International journal of oncology Mar, 2016 | Pubmed ID: 26718269
An MMP-2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer.
ACS applied materials & interfaces Feb, 2016 | Pubmed ID: 26759926
Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes.
Oncotarget Mar, 2016 | Pubmed ID: 26872370
Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma.
Cancer letters Aug, 2016 | Pubmed ID: 27212442
Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy.
Biomaterials Sep, 2016 | Pubmed ID: 27343466
IGFBP2 Activates the NF-κB Pathway to Drive Epithelial-Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma.
Cancer research Sep, 2016 | Pubmed ID: 27659045
Monoubiquitination Inhibits the Actin Bundling Activity of Fascin.
The Journal of biological chemistry Dec, 2016 | Pubmed ID: 27879315
ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin.
Cancer research Feb, 2017 | Pubmed ID: 27923832
Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression.
Nature communications 01, 2017 | Pubmed ID: 28102193
HIF-2-dependent expression of stem cell factor promotes metastasis in hepatocellular carcinoma.
Cancer letters May, 2017 | Pubmed ID: 28153790
Detection of Circulating Tumor Cells Using Negative Enrichment Immunofluorescence and an In Situ Hybridization System in Pancreatic Cancer.
International journal of molecular sciences Mar, 2017 | Pubmed ID: 28333072
A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer.
Cancer letters Aug, 2017 | Pubmed ID: 28576749
Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy.
ACS nano Sep, 2017 | Pubmed ID: 28806504
Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice.
Gastroenterology 02, 2018 | Pubmed ID: 28989066
Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment.
Biomaterials Mar, 2018 | Pubmed ID: 29275122
A new combined criterion to better predict malignant lesions in patients with pancreatic cystic neoplasms.
Cancer biology & medicine Feb, 2018 | Pubmed ID: 29545970
Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth.
ACS nano Feb, 2019 | Pubmed ID: 30676731
LIMS1 Promotes Pancreatic Cancer Cell Survival under Oxygen-Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation.
Clinical cancer research : an official journal of the American Association for Cancer Research 07, 2019 | Pubmed ID: 30679163
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.
The Journal of experimental medicine Mar, 2019 | Pubmed ID: 30733283
RETRACTED: HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma.
Cancer letters Jul, 2019 | Pubmed ID: 30922919
Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments.
Cell reports Sep, 2019 | Pubmed ID: 31509745
Correction: Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma.
Oncotarget Sep, 2019 | Pubmed ID: 31565190
The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma.
EMBO molecular medicine Dec, 2019 | Pubmed ID: 31633874
IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer.
Theranostics , 2020 | Pubmed ID: 32226541
PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC.
Signal transduction and targeted therapy Apr, 2020 | Pubmed ID: 32300119
Dedifferentiation of Epithelial Cells Incorporates Immune Reprogramming.
Trends in cell biology Apr, 2021 | Pubmed ID: 33593679
ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4.
Gut Feb, 2022 | Pubmed ID: 33674341
Delta HU is a potential marker to predict chemotherapy response for unresectable pancreatic ductal adenocarcinoma.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Jun, 2021 | Pubmed ID: 33712388
Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
Journal of cachexia, sarcopenia and muscle Jun, 2021 | Pubmed ID: 33763996
PERK-eIF2α-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer.
Cancer letters Sep, 2021 | Pubmed ID: 34052329
Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer.
Cancer biology & medicine Jun, 2021 | Pubmed ID: 34086429
CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising target with non-canonical mechanisms.
Cancer letters Oct, 2021 | Pubmed ID: 34302921
Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression.
Cancer letters Oct, 2021 | Pubmed ID: 34303764
VannoPortal: multiscale functional annotation of human genetic variants for interrogating molecular mechanism of traits and diseases.
Nucleic acids research Jan, 2022 | Pubmed ID: 34570217
Corrigendum to "Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer" [Biomaterials 46 (2015) 13-25].
Biomaterials Jan, 2022 | Pubmed ID: 34890971
BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation.
Gastroenterology Apr, 2022 | Pubmed ID: 34951995
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma.
Cell discovery Feb, 2022 | Pubmed ID: 35165277
SOX8 Affects Tumoral SPARC Expression by Regulating EZH2 to Attenuate Effectiveness of albumin-bound paclitaxel in PDAC.
International journal of biological sciences , 2022 | Pubmed ID: 35173526
LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin.
Genome biology Feb, 2022 | Pubmed ID: 35227284
Perioperative Serum Scoring Systems Predict Early Recurrence and Poor Prognosis of Resectable Pancreatic Cancer.
Frontiers in oncology , 2022 | Pubmed ID: 35265528
Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer.
Cancer research Jun, 2022 | Pubmed ID: 35413105
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.
Molecular cell Jul, 2022 | Pubmed ID: 35597237
Robotic Distal Pancreatectomy, a Novel Standard of Care? Benchmark Values for Surgical Outcomes from 16 International Expert Centers.
Annals of surgery Jul, 2022 | Pubmed ID: 35861061
Genome-wide CRISPR screen identifies MTA3 as an inducer of gemcitabine resistance in pancreatic ductal adenocarcinoma.
Cancer letters Nov, 2022 | Pubmed ID: 35981571
ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour-stromal IL-1β/NF-κB/ESE3 signalling axis.
British journal of cancer Nov, 2022 | Pubmed ID: 35986089
Comparison of the long-term outcomes of patients with hepatocellular carcinoma within the Milan criteria treated by ablation, resection, or transplantation.
Cancer medicine Feb, 2023 | Pubmed ID: 36016484
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A.
Cell & bioscience Nov, 2022 | Pubmed ID: 36371321
CD73, a Promising Therapeutic Target of Diclofenac, Promotes Metastasis of Pancreatic Cancer through a Nucleotidase Independent Mechanism.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Feb, 2023 | Pubmed ID: 36563135
The relevance between hypoxia-dependent spatial transcriptomics and the prognosis and efficacy of immunotherapy in claudin-low breast cancer.
Frontiers in immunology , 2022 | Pubmed ID: 36685583
Retraction notice to "HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma" [Cancer Lett. 453 (2019) 10-20].
Cancer letters Apr, 2023 | Pubmed ID: 36813650
SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.
Gut Feb, 2023 | Pubmed ID: 36828627
An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.
Nature communications Mar, 2023 | Pubmed ID: 36869052
Survival outcomes of neoadjuvant therapy followed by radical resection versus upfront surgery for stage I-III pancreatic ductal adenocarcinoma: a retrospective cohort study.
International journal of surgery (London, England) Jun, 2023 | Pubmed ID: 37132194
Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis.
Journal of experimental & clinical cancer research : CR May, 2023 | Pubmed ID: 37143164
Selective extended dissection for pancreaticoduodenectomy is associated with better survival in pancreatic cancer patients: retrospective cohort study.
International journal of surgery (London, England) Jul, 2023 | Pubmed ID: 37195787
Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma.
Cancer biology & medicine Jun, 2023 | Pubmed ID: 37381714
BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis.
Signal transduction and targeted therapy Jul, 2023 | Pubmed ID: 37443111
The Hippo/YAP signaling pathway: the driver of cancer metastasis.
Cancer biology & medicine Jul, 2023 | Pubmed ID: 37493303
A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma.
iScience Sep, 2023 | Pubmed ID: 37664604
High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast.
Frontiers of medicine Oct, 2023 | Pubmed ID: 37682378
Combination of RUNX1 inhibitor and gemcitabine mitigates chemo-resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress.
Journal of experimental & clinical cancer research : CR Sep, 2023 | Pubmed ID: 37697370
Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Dec, 2023 | Pubmed ID: 37819952
ADAR1 links R-loop homeostasis to ATR activation in replication stress response.
Nucleic acids research Nov, 2023 | Pubmed ID: 37831098
A Novel Bifidobacterium/Klebsiella Ratio in Characterization Analysis of the Gut and Bile Microbiota of CCA Patients.
Microbial ecology Nov, 2023 | Pubmed ID: 38030815
Unraveling the causal genes and transcriptomic determinants of human telomere length.
Nature communications Dec, 2023 | Pubmed ID: 38129441
Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis.
Signal transduction and targeted therapy Jan, 2024 | Pubmed ID: 38177109
Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma.
Oncogene Mar, 2024 | Pubmed ID: 38243080
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
Molecular cell Apr, 2024 | Pubmed ID: 38423014
Integrating tertiary lymphoid structure-associated genes into computational models to evaluate prognostication and immune infiltration in pancreatic cancer.
Journal of leukocyte biology Sep, 2024 | Pubmed ID: 38484172
Targeting ESE3/EHF With Nifurtimox Inhibits CXCR2 Neutrophil Infiltration and Overcomes Pancreatic Cancer Resistance to Chemotherapy and Immunotherapy.
Gastroenterology Jul, 2024 | Pubmed ID: 38492894
EGC enhances tumor antigen presentation and CD8 T cell-mediated antitumor immunity via targeting oncoprotein SND1.
Cancer letters Jun, 2024 | Pubmed ID: 38710299
BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism.
Science advances Jun, 2024 | Pubmed ID: 38896624
Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of pancreatic cancer.
Journal of the National Cancer Center Dec, 2022 | Pubmed ID: 39036552
CD64 fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8 T cells.
Gut Nov, 2024 | Pubmed ID: 39187291
Survival outcomes of adjuvant chemotherapy in patients with stage I pancreatic cancer stratified by pathologic risk.
Surgery Nov, 2024 | Pubmed ID: 39191600
Computational modeling of mast cell tryptase family informs selective inhibitor development.
iScience Sep, 2024 | Pubmed ID: 39280611
A prospective study of neoadjuvant pembrolizumab plus chemotherapy for resectable esophageal squamous cell carcinoma: The Keystone-001 trial.
Cancer cell Oct, 2024 | Pubmed ID: 39406186
Hypoxic and Acidic Tumor Microenvironment-Driven AVL9 Promotes Chemoresistance of Pancreatic Ductal Adenocarcinoma via the AVL9-IκBα-SKP1 Complex.
Gastroenterology Nov, 2024 | Pubmed ID: 39566663
The nuclear condensates of ESE3/EHF induce cellular senescence without the associated inflammatory secretory phenotype in pancreatic ductal adenocarcinoma.
Cancer letters Dec, 2024 | Pubmed ID: 39710057
Xiangqin Zhao1,
Xinbo Gao1,
Wenwen Yu2,
Yi Lu1,
Xuesong Li1,
Lu Tan3,
Xiubao Ren2,
Yifei Wang1,
Weijie Song4,
Jihui Hao1,
Ying Ma1
1Department of Pancreatic Cancer, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital,
2Department of Immunology and Biotherapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Immunology and Biotherapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital,
3Research Core Facility, School of Basic Medical Sciences, Tianjin Medical University,
4Department of Public Laboratory, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital
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