Bruce A. Molitoris

Medicine/Nephrology, Indiana University School of Medicine

Affiliated withIndiana University School of Medicine Indiana University School of Medicine

Research Area

MedicineUnit 1

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2013
Publication title	2022

Other Publications

Article	Year
Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking. Journal of the American Society of Nephrology : JASN\| PubMed ID: 11134257	2001
Ischemia induces alterations in actin filaments in renal vascular smooth muscle cells. American journal of physiology. Renal physiology\| PubMed ID: 11997317	2002
Endothelial injury and dysfunction in ischemic acute renal failure. Critical care medicine\| PubMed ID: 12004242	2002
Functional studies of the kidney of living animals using multicolor two-photon microscopy. American journal of physiology. Cell physiology\| PubMed ID: 12176747	2002
Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney international\| PubMed ID: 12371954	2002
Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells. American journal of physiology. Renal physiology\| PubMed ID: 12388419	2002
Cardiovascular disease in patients with chronic kidney disease. Seminars in nephrology\| PubMed ID: 12430090	2002
Transitioning to therapy in ischemic acute renal failure. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12506160	2003
ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion. American journal of physiology. Renal physiology\| PubMed ID: 12620926	2003
A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis. American journal of physiology. Cell physiology\| PubMed ID: 12676658	2003
Injury of the renal microvascular endothelium alters barrier function after ischemia. American journal of physiology. Renal physiology\| PubMed ID: 12684225	2003
Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 12722043	2003
Intravital imaging of the kidney using multiparameter multiphoton microscopy. Nephron. Experimental nephrology\| PubMed ID: 12806182	2003
Newly developed techniques to study and diagnose acute renal failure. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12874475	2003
Mechanism of actin polymerization in cellular ATP depletion. The Journal of biological chemistry\| PubMed ID: 14623892	2004
Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum. American journal of physiology. Renal physiology\| PubMed ID: 14625200	2004
Renal ischemia induces tropomyosin dissociation-destabilizing microvilli microfilaments. American journal of physiology. Renal physiology\| PubMed ID: 15075195	2004
Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy. American journal of physiology. Cell physiology\| PubMed ID: 15102609	2004
Endothelial injury and dysfunction: role in the extension phase of acute renal failure. Kidney international\| PubMed ID: 15253696	2004
Actin cytoskeleton in ischemic acute renal failure. Kidney international\| PubMed ID: 15253754	2004
Intravital multiphoton microscopy of dynamic renal processes. American journal of physiology. Renal physiology\| PubMed ID: 15883167	2005
Micropuncture gene delivery and intravital two-photon visualization of protein expression in rat kidney. American journal of physiology. Renal physiology\| PubMed ID: 15886277	2005
Quantitative intravital microscopy using a Generalized Polarity concept for kidney studies. American journal of physiology. Cell physiology\| PubMed ID: 16033906	2005
Renal blood flow in sepsis: a complex issue. Critical care (London, England)\| PubMed ID: 16137373	2005
Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16169279	2005
Cofilin mediates ATP depletion-induced endothelial cell actin alterations. American journal of physiology. Renal physiology\| PubMed ID: 16434575	2006
Loss of the homotypic fusion and vacuole protein sorting or golgi-associated retrograde protein vesicle tethering complexes results in gentamicin sensitivity in the yeast Saccharomyces cerev... Antimicrobial agents and chemotherapy\| PubMed ID: 16436714	2006
Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16495381	2006
Advances in imaging the kidney and cellular processes. Nephron. Experimental nephrology\| PubMed ID: 16543761	2006
Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals. Cellular microbiology\| PubMed ID: 16953802	2007
A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16971659	2006
Pharmacophotonics: utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney. Advanced drug delivery reviews\| PubMed ID: 17064810	2006
Rapid determination of renal filtration function using an optical ratiometric imaging approach. American journal of physiology. Renal physiology\| PubMed ID: 17311910	2007
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Critical care (London, England)\| PubMed ID: 17331245	2007
Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2. American journal of physiology. Renal physiology\| PubMed ID: 17409278	2007
Quantifying dynamic kidney processes utilizing multi-photon microscopy. Contributions to nephrology\| PubMed ID: 17464132	2007
Improving outcomes from acute kidney injury: report of an initiative. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 17591518	2007
Improving outcomes from acute kidney injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 17596636	2007
Improving outcomes of acute kidney injury: report of an initiative. Nature clinical practice. Nephrology\| PubMed ID: 17653122	2007
Progression of bacterial infections studied in real time--novel perspectives provided by multiphoton microscopy. Cellular microbiology\| PubMed ID: 17662072	2007
Improving outcomes from acute kidney injury: report of an initiative. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 17665221	2007
Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 18216348	2008
Technology Insight: biomarker development in acute kidney injury--what can we anticipate? Nature clinical practice. Nephrology\| PubMed ID: 18227821	2008
Quantifying endocytosis in vivo using intravital two-photon microscopy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18369960	2008
Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis. Cellular microbiology\| PubMed ID: 18549455	2008
Improvements in the diagnosis of acute kidney injury. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia\| PubMed ID: 18580009	2008
Contrast nephropathy: are short-term outcome measures adequate for quantification of long-term renal risk? Nature clinical practice. Nephrology\| PubMed ID: 18779854	2008
Imaging techniques in acute kidney injury. Nephron. Clinical practice\| PubMed ID: 18802368	2008
Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. The Journal of biological chemistry\| PubMed ID: 18922801	2008
Acute kidney injury increases risk of ESRD among elderly. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19020007	2009
Impaired tubular uptake explains albuminuria in early diabetic nephropathy. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19118149	2009
Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation. American journal of physiology. Renal physiology\| PubMed ID: 19144696	2009
Techniques to study nephron function: microscopy and imaging. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 19145447	2009
Soluble thrombomodulin protects ischemic kidneys. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19176699	2009
Ironing out the pathogenesis of acute kidney injury. American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 19324244	2009
Illuminating mitochondrial function and dysfunction using multiphoton technology. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19470668	2009
siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19470675	2009
Managing conflicts of interest: the road ahead. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19713304	2009
ASN policy on managing conflicts of interest. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19713305	2009
Activated protein C and acute kidney injury: Selective targeting of PAR-1. Current drug targets\| PubMed ID: 19715537	2009
Early monitoring of acute tubular necrosis in the rat kidney by 23Na-MRI. American journal of physiology. Renal physiology\| PubMed ID: 19726545	2009
Multiphoton imaging techniques in acute kidney injury. Contributions to nephrology\| PubMed ID: 20427955	2010
Rapid diagnosis and quantification of acute kidney injury using fluorescent ratio-metric determination of glomerular filtration rate in the rat. American journal of physiology. Renal physiology\| PubMed ID: 20685826	2010
Intravital two-photon microscopy assessment of renal protection efficacy of siRNA for p53 in experimental rat kidney transplantation models. Cell transplantation\| PubMed ID: 20719069	2010
Lessons from Haiti on disaster relief. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 20947792	2010
The antibiotic gentamicin inhibits specific protein trafficking functions of the Arf1/2 family of GTPases. Antimicrobial agents and chemotherapy\| PubMed ID: 20956596	2011
Yet another advance in understanding albuminuria? Journal of the American Society of Nephrology : JASN\| PubMed ID: 21051742	2010
Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury. American journal of physiology. Renal physiology\| PubMed ID: 21123492	2011
Acute kidney injury in older adults. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21209252	2011
Pathophysiology of ischemic acute kidney injury. Nature reviews. Nephrology\| PubMed ID: 21364518	2011
Uropathogenic Escherichia coli P and Type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction. PLoS pathogens\| PubMed ID: 21383970	2011
The future nephrology workforce: will there be one? Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 21551020	2011
Implications of a nephrology workforce shortage for dialysis patient care. Seminars in dialysis\| PubMed ID: 21682769	2011
Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact. The American journal of pathology\| PubMed ID: 21703395	2011
Circulating micro-RNAs in acute kidney injury: early observations. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 21734080	2011
Disease-specific kidney imaging: introduction. Seminars in nephrology\| PubMed ID: 21784271	2011
A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals. Kidney international\| PubMed ID: 21881552	2012
Kidney endothelial dysfunction: ischemia, localized infections and sepsis. Contributions to nephrology\| PubMed ID: 21921615	2011
Multiple factors influence glomerular albumin permeability in rats. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22223875	2012
Multiphoton microscopy applied for real-time intravital imaging of bacterial infections in vivo. Methods in enzymology\| PubMed ID: 22341218	2012
Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 22442182	2012
Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 22442184	2012
Designing clinical trials in acute kidney injury. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 22442185	2012
Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 22442188	2012
A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney. Clinical and experimental nephrology\| PubMed ID: 22678524	2012
Chronic endothelin-1 infusion elevates glomerular sieving coefficient and proximal tubular albumin reuptake in the rat. Life sciences\| PubMed ID: 22727794	2012
Toxicological and pharmacokinetic properties of chemically modified siRNAs targeting p53 RNA following intravenous administration. Nucleic acid therapeutics\| PubMed ID: 22913596	2012
In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury. Kidney international\| PubMed ID: 22992467	2013
Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet. Critical care (London, England)\| PubMed ID: 23014799	2012
AKI is around the world but public recognition is lacking. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 23949233	2013
Measuring glomerular filtration rate in the intensive care unit: no substitutes please. Critical care (London, England)\| PubMed ID: 24004539	2013
Screening: Screening for kidney disease--a lost opportunity. Nature reviews. Nephrology\| PubMed ID: 24296624	2014
The proximal tubule and albuminuria: really! Journal of the American Society of Nephrology : JASN\| PubMed ID: 24408874	2014
ASN Presidential Address 2013: innovation and individualization--the path forward for nephrology. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24676637	2014
Letter to the editor: "Quantifying albumin permeability with multiphoton microscopy: why the difference?". American journal of physiology. Renal physiology\| PubMed ID: 24785957	2014
Therapeutic translation in acute kidney injury: the epithelial/endothelial axis. The Journal of clinical investigation\| PubMed ID: 24892710	2014
Using 2-photon microscopy to understand albuminuria. Transactions of the American Clinical and Climatological Association\| PubMed ID: 25125750	2014
Dynamic multiphoton microscopy: focusing light on acute kidney injury. Physiology (Bethesda, Md.)\| PubMed ID: 25180263	2014
Finding the bottom and using it: Offsets and sensitivity in the detection of low intensity values in vivo with 2-photon microscopy. Intravital\| PubMed ID: 25313346	2014
Urinary Biomarkers: Alone Are They Enough? Journal of the American Society of Nephrology : JASN\| PubMed ID: 25535304	2015
Shear stress is normalized in glomerular capillaries following ⅚ nephrectomy. American journal of physiology. Renal physiology\| PubMed ID: 25587117	2015
Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): a randomised clinical trial. The lancet. Diabetes & endocrinology\| PubMed ID: 25660356	2015
Renal endothelial injury and microvascular dysfunction in acute kidney injury. Seminars in nephrology\| PubMed ID: 25795503	2015
Proximal Tubules Have the Capacity to Regulate Uptake of Albumin. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26054544	2016
Nephrology research--the past, present and future. Nature reviews. Nephrology\| PubMed ID: 26416499	2015
Renal Hemodynamics in AKI: In Search of New Treatment Targets. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26510884	2016
Mechanism of increased clearance of glycated albumin by proximal tubule cells. American journal of physiology. Renal physiology\| PubMed ID: 26887834	2016
Quantifying Glomerular Filtration Rates in Acute Kidney Injury: A Requirement for Translational Success. Seminars in nephrology\| PubMed ID: 27085733	2016
Inhibition of v5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 28062569	2017
Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys. Journal of the American Society of Nephrology : JASN\| PubMed ID: 28122967	2017
Rethinking CKD Evaluation: Should We Be Quantifying Basal or Stimulated GFR to Maximize Precision and Sensitivity? American journal of kidney diseases : the official journal of the National Kidney Foundation\| PubMed ID: 28223001	2017
Intravital Imaging of the Kidney in a Rat Model of Salt-Sensitive Hypertension. American journal of physiology. Renal physiology\| PubMed ID: 28404591	2017
Intravital multiphoton microscopy as a tool for studying renal physiology and pathophysiology. Methods (San Diego, Calif.)\| PubMed ID: 28733090	2017
Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection. Journal of the American Society of Nephrology : JASN\| PubMed ID: 29371417	2018
Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147. Pathogens and disease\| PubMed ID: 30476069	2018
A Novel Fluorescent Clinical Method to Rapidly Quantify Plasma Volume. Cardiorenal medicine\| PubMed ID: 30844821	2019
Beyond Biomarkers: Machine Learning in Diagnosing Acute Kidney Injury. Mayo Clinic proceedings\| PubMed ID: 31054601	2019
Fluorescent Imaging and Microscopy for Dynamic Processes in Rats. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31228156	2019
Application of physiological shear stress to renal tubular epithelial cells. Methods in cell biology\| PubMed ID: 31395384	2019
DNA damage response protects against progressive kidney disease. The Journal of clinical investigation\| PubMed ID: 31589167	2019
Kidney Mentoring and Assessment Program for Students: a guide for engaging medical students in nephrology. Clinical kidney journal\| PubMed ID: 31807288	2019
Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32123080	2020
Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease. JCI insight\| PubMed ID: 33001861	2020
Real-time glomerular filtration rate: improving sensitivity, accuracy and prognostic value in acute kidney injury. Current opinion in critical care\| PubMed ID: 33002974	2020
Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance. American journal of physiology. Renal physiology\| PubMed ID: 33283642	2021
The Indiana O'Brien Center for Advanced Renal Microscopic Analysis. American journal of physiology. Renal physiology\| PubMed ID: 33682441	2021