Stephen T.C. Wong

Center for biotechnology and Informatics, The Methodist Hospital Research Institute

Affiliated withThe Methodist Hospital Research Institute The Methodist Hospital, Weill Cornell Medical College

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2009

Other Publications

Article	Year
Design and applications of a multimodality image data warehouse framework. Journal of the American Medical Informatics Association : JAMIA\| PubMed ID: 11971885	2002
Workflow-enabled distributed component-based information architecture for digital medical imaging enterprises. IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society\| PubMed ID: 14518730	2003
A neuroinformatics database system for disease-oriented neuroimaging research. Academic radiology\| PubMed ID: 15035525	2004
Towards effective and rewarding data sharing. Neuroinformatics\| PubMed ID: 15046250	2003
A web-based federated neuroinformatics model for surgical planning and clinical research applications in epilepsy. Neuroinformatics\| PubMed ID: 15067170	2004
Cancer classification and prediction using logistic regression with Bayesian gene selection. Journal of biomedical informatics\| PubMed ID: 15465478	2004
DBMap: a space-conscious data visualization and knowledge discovery framework for biomedical data warehouse. IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society\| PubMed ID: 15484440	2004
A computerized cellular imaging system for high content analysis in Monastrol suppressor screens. Journal of biomedical informatics\| PubMed ID: 16011909	2006
Multiclass cancer classification by using fuzzy support vector machine and binary decision tree with gene selection. Journal of biomedicine & biotechnology\| PubMed ID: 16046822	2005
Parameters selection in gene selection using Gaussian kernel support vector machines by genetic algorithm. Journal of Zhejiang University. Science. B\| PubMed ID: 16187409	2005
Computerized image analysis for quantitative neuronal phenotyping in zebrafish. Journal of neuroscience methods\| PubMed ID: 16364449	2006
76-space analysis of grey matter diffusivity: methods and applications. NeuroImage\| PubMed ID: 16434215	2006
Protein structure similarity from Principle Component Correlation analysis. BMC bioinformatics\| PubMed ID: 16436213	2006
Boosting alternating decision trees modeling of disease trait information. BMC genetics\| PubMed ID: 16451591	2005
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. Journal of neurochemistry\| PubMed ID: 16464238	2006
Mutual information-based feature selection in studying perturbation of dendritic structure caused by TSC2 inactivation. Neuroinformatics\| PubMed ID: 16595860	2006
Bayesian variable selection for gene expression modeling with regulatory motif binding sites in neuroinflammatory events. Neuroinformatics\| PubMed ID: 16595861	2006
Automated segmentation, classification, and tracking of cancer cell nuclei in time-lapse microscopy. IEEE transactions on bio-medical engineering\| PubMed ID: 16602586	2006
Automated neurite labeling and analysis in fluorescence microscopy images. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 16680708	2006
76-space analysis of grey matter diffusivity: methods and applications. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 16685840	2005
Towards automated cellular image segmentation for RNAi genome-wide screening. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 16685930	2005
Repulsive force based snake model to segment and track neuronal axons in 3D microscopy image stacks. NeuroImage\| PubMed ID: 16861006	2006
A novel tracing algorithm for high throughput imaging Screening of neuron-based assays. Journal of neuroscience methods\| PubMed ID: 16987551	2007
Context based mixture model for cell phase identification in automated fluorescence microscopy. BMC bioinformatics\| PubMed ID: 17263881	2007
Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. NeuroImage\| PubMed ID: 17363284	2007
Detection of molecular particles in live cells via machine learning. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 17431884	2007
Characteristic of hypothalamic kisspeptin expression in the pubertal development of precocious female rats. Neuroscience letters\| PubMed ID: 17442487	2007
An automated feedback system with the hybrid model of scoring and classification for solving over-segmentation problems in RNAi high content screening. Journal of microscopy\| PubMed ID: 17444941	2007
Dendritic spine detection using curvilinear structure detector and LDA classifier. NeuroImage\| PubMed ID: 17448688	2007
Tracking molecular particles in live cells using fuzzy rule-based system. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 17542029	2007
Automatic dendritic spine analysis in two-photon laser scanning microscopy images. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 17654649	2007
Detection of blob objects in microscopic zebrafish images based on gradient vector diffusion. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 17654652	2007
3D cell nuclei segmentation based on gradient flow tracking. BMC cell biology\| PubMed ID: 17784958	2007
Brain tissue segmentation based on DTI data. NeuroImage\| PubMed ID: 17804258	2007
Automated axon tracking of 3D confocal laser scanning microscopy images using guided probabilistic region merging. Neuroinformatics\| PubMed ID: 17917130	2007
High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles. BMC biotechnology\| PubMed ID: 17925027	2007
Comparison of reversible-jump Markov-chain-Monte-Carlo learning approach with other methods for missing enzyme identification. Journal of biomedical informatics\| PubMed ID: 17950040	2008
Least-square conformal brain mapping with spring energy. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society\| PubMed ID: 17950575	2007
Novel cell segmentation and online SVM for cell cycle phase identification in automated microscopy. Bioinformatics (Oxford, England)\| PubMed ID: 17989093	2008
ZFIQ: a software package for zebrafish biology. Bioinformatics (Oxford, England)\| PubMed ID: 18089619	2008
Cellular phenotype recognition for high-content RNA interference genome-wide screening. Journal of biomolecular screening\| PubMed ID: 18227224	2008
An automated method for cell detection in zebrafish. Neuroinformatics\| PubMed ID: 18288618	2008
Reconstruction of central cortical surface from brain MRI images: method and application. NeuroImage\| PubMed ID: 18289879	2008
MR analysis of regional brain volume in adolescent idiopathic scoliosis: neurological manifestation of a systemic disease. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 18302230	2008
3D Axon structure extraction and analysis in confocal fluorescence microscopy images. Neural computation\| PubMed ID: 18336075	2008
Using nonlinear diffusion and mean shift to detect and connect cross-sections of axons in 3D optical microscopy images. Medical image analysis\| PubMed ID: 18440853	2008
A quantitative study of factors affecting in vivo bioluminescence imaging. Luminescence : the journal of biological and chemical luminescence\| PubMed ID: 18452141	2008
Workflow and methods of high-content time-lapse analysis for quantifying intracellular calcium signals. Neuroinformatics\| PubMed ID: 18506641	2008
MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (New York, N.Y.)\| PubMed ID: 18511691	2008
Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC bioinformatics\| PubMed ID: 18534020	2008
An image score inference system for RNAi genome-wide screening based on fuzzy mixture regression modeling. Journal of biomedical informatics\| PubMed ID: 18547870	2009
Reversible jump MCMC approach for peak identification for stroke SELDI mass spectrometry using mixture model. Bioinformatics (Oxford, England)\| PubMed ID: 18586741	2008
The knowledge-integrated network biomarkers discovery for major adverse cardiac events. Journal of proteome research\| PubMed ID: 18665624	2008
Registration of 3-D CT and 2-D flat images of mouse via affine transformation. IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society\| PubMed ID: 18779071	2008
Computational prediction models for early detection of risk of cardiovascular events using mass spectrometry data. IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society\| PubMed ID: 18779078	2008
Robust 3D reconstruction and identification of dendritic spines from optical microscopy imaging. Medical image analysis\| PubMed ID: 18819835	2009
Conditional random pattern algorithm for LOH inference and segmentation. Bioinformatics (Oxford, England)\| PubMed ID: 18974074	2009
A novel method for cortical sulcal fundi extraction. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 18979757	2008
Multiple distinct clones may co-exist in different lineages in myelodysplastic syndromes. Leukemia research\| PubMed ID: 19084271	2009
Improved residue function and reduced flow dependence in MR perfusion using least-absolute-deviation regularization. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 19161133	2009
A screening platform for glioma growth and invasion using bioluminescence imaging. Laboratory investigation. Journal of neurosurgery\| PubMed ID: 19199503	2009
Introduction to the special issue of "Advances in Molecular Imaging". European journal of radiology\| PubMed ID: 19261413	2009
A novel cell segmentation method and cell phase identification using Markov model. IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society\| PubMed ID: 19272857	2009
Identification of biomarkers for risk stratification of cardiovascular events using genetic algorithm with recursive local floating search. Proteomics\| PubMed ID: 19337989	2009
Pattern-selection based power analysis and discrimination of low- and high-grade myelodysplastic syndromes study using SNP arrays. PloS one\| PubMed ID: 19352488	2009
An automated pipeline for dendrite spine detection and tracking of 3D optical microscopy neuron images of in vivo mouse models. Neuroinformatics\| PubMed ID: 19434521	2009
Automated brain tumor segmentation using spatial accuracy-weighted hidden Markov Random Field. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society\| PubMed ID: 19446435	2009
生物发光成像显示由阿尔茨海默病中的淀粉样蛋白抑&#x523... Cancer cell international\| PubMed ID: 19480719	2009
Conference Scene: Wake-up call for the engineering and biomedical science communities in nanomedicine. Nanomedicine (London, England)\| PubMed ID: 19572817	2009
Multiple nuclei tracking using integer programming for quantitative cancer cell cycle analysis. IEEE transactions on medical imaging\| PubMed ID: 19643704	2010
A novel peak detection approach with chemical noise removal using short-time FFT for prOTOF MS data. Proteomics\| PubMed ID: 19681055	2009
A hybrid approach to automatic clustering of white matter fibers. NeuroImage\| PubMed ID: 19683061	2010
Simultaneous consideration of spatial deformation and tensor orientation in diffusion tensor image registration using local fast marching patterns. Information processing in medical imaging : proceedings of the ... conference\| PubMed ID: 19694253	2009
Joint registration and segmentation of serial lung CT images for image-guided lung cancer diagnosis and therapy. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society\| PubMed ID: 19709855	2010
Computational Systems Bioinformatics and Bioimaging for Pathway Analysis and Drug Screening. Proceedings of the IEEE. Institute of Electrical and Electronics Engineers\| PubMed ID: 20011613	2008
A NOVEL SURFACE-BASED GEOMETRIC APPROACH FOR 3D DENDRITIC SPINE DETECTION FROM MULTI-PHOTON EXCITATION MICROSCOPY IMAGES. Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging\| PubMed ID: 20046805	2009
Computer-assisted quantitative evaluation of therapeutic responses for lymphoma using serial PET/CT imaging. Academic radiology\| PubMed ID: 20060747	2010
A neurocomputational method for fully automated 3D dendritic spine detection and segmentation of medium-sized spiny neurons. NeuroImage\| PubMed ID: 20100579	2010
Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 20156674	2010
Online Phenotype Discovery based on Minimum Classification Error Model. Pattern recognition\| PubMed ID: 20161245	2009
Catch the wave--nanotechnology, the future is now. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society\| PubMed ID: 20209671	2010
A local fast marching-based diffusion tensor image registration algorithm by simultaneously considering spatial deformation and tensor orientation. NeuroImage\| PubMed ID: 20382233	2010
Conditional random pattern model for copy number aberration detection. BMC bioinformatics\| PubMed ID: 20412592	2010
Cell segmentation using front vector flow guided active contours. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 20426162	2009
An automatic and robust algorithm of reestablishment of digital dental occlusion. IEEE transactions on medical imaging\| PubMed ID: 20529735	2010
Reconstruction of the neuromuscular junction connectome. Bioinformatics (Oxford, England)\| PubMed ID: 20529938	2010
A computational framework for studying neuron morphology from in vitro high content neuron-based screening. Journal of neuroscience methods\| PubMed ID: 20580743	2010
INTEGRATING MULTI-SCALE BLOB/CURVILINEAR DETECTOR TECHNIQUES AND MULTI-LEVEL SETS FOR AUTOMATED SEGMENTATION OF STEM CELL IMAGES. Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging\| PubMed ID: 20585412	2009
An Image Based System Biology Approach for Alzheimer's Disease Pathway Analysis. IEEE/NIH Life Science Systems and Applications Workshop. IEEE/NIH Life Science Systems and Applications Workshop\| PubMed ID: 20585413	2009
Oriented Markov random field based dendritic spine segmentation for fluorescence microscopy images. Neuroinformatics\| PubMed ID: 20585900	2010
Delivery of picosecond lasers in multimode fibers for coherent anti-Stokes Raman scattering imaging. Optics express\| PubMed ID: 20588430	2010
Cortical and frontal atrophy are associated with cognitive impairment in age-related confluent white-matter lesion. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 20826875	2011
Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces. BMC systems biology\| PubMed ID: 20840733	2010
Image-based chemical screening identifies drug efflux inhibitors in lung cancer cells. Cancer research\| PubMed ID: 20841476	2010
Online 4-D CT estimation for patient-specific respiratory motion based on real-time breathing signals. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 20879424	2010
Motion artifact correction of multi-photon imaging of awake mice models using speed embedded HMM. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention\| PubMed ID: 20879434	2010
Diffusion tensor-based fast marching for modeling human brain connectivity network. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society\| PubMed ID: 21035304	2011
Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients. Pharmacogenomics\| PubMed ID: 21047202	2010
A global spatial similarity optimization scheme to track large numbers of dendritic spines in time-lapse confocal microscopy. IEEE transactions on medical imaging\| PubMed ID: 21047709	2011
MicroRNA-integrated and network-embedded gene selection with diffusion distance. PloS one\| PubMed ID: 21060785	2010
Multi scale and slice-based approach for automatic spine detection. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference\| PubMed ID: 21096249	2010
Coronary artery segmentation using geometric moments based tracking and snake-driven refinement. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference\| PubMed ID: 21096589	2010
Characterization of a human tumorsphere glioma orthotopic model using magnetic resonance imaging. Journal of neuro-oncology\| PubMed ID: 21240539	2011
The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models. Breast cancer research and treatment\| PubMed ID: 21394501	2012
Progress of engineered antibody-targeted molecular imaging for solid tumors (Review). Molecular medicine reports\| PubMed ID: 21479389	2008
Label-free high-resolution imaging of prostate glands and cavernous nerves using coherent anti-Stokes Raman scattering microscopy. Biomedical optics express\| PubMed ID: 21483613	2011
Peak tree: a new tool for multiscale hierarchical representation and peak detection of mass spectrometry data. IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM\| PubMed ID: 21566254	2011
Coherent anti-Stokes Raman scattering microscopy imaging with suppression of four-wave mixing in optical fibers. Optics express\| PubMed ID: 21643045	2011
An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data. Bioinformatics (Oxford, England)\| PubMed ID: 21685086	2011
Real-time monitoring of cell viability using direct electrical measurement with a patch-clamp microchip. Biomedical microdevices\| PubMed ID: 21698381	2011
Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging. Optics letters\| PubMed ID: 21808374	2011
Differential diagnosis of breast cancer using quantitative, label-free and molecular vibrational imaging. Biomedical optics express\| PubMed ID: 21833355	2011
Motion correction for cellular-resolution multi-photon fluorescence microscopy imaging of awake head-restrained mice using speed embedded HMM. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society\| PubMed ID: 21890321	2011
ONLINE THREE-DIMENSIONAL DENDRITIC SPINES MOPHOLOGICAL CLASSIFICATION BASED ON SEMI-SUPERVISED LEARNING. Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging\| PubMed ID: 21922077	2009
An Image Driven Systems Biology Approach for Neurodegenerative Disease Studies in the TSC-mTOR Pathway. IEEE/NIH Life Science Systems and Applications Workshop. IEEE/NIH Life Science Systems and Applications Workshop\| PubMed ID: 21922078	2009
On-the-spot lung cancer differential diagnosis by label-free, molecular vibrational imaging and knowledge-based classification. Journal of biomedical optics\| PubMed ID: 21950918	2011
A time-series method for automated measurement of changes in mitotic and interphase duration from time-lapse movies. PloS one\| PubMed ID: 21966537	2011
The kinetochore protein Bub1 participates in the DNA damage response. DNA repair\| PubMed ID: 22071147	2012
Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint. Molecular cell\| PubMed ID: 22099307	2011
A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy. Cancer research\| PubMed ID: 22108825	2012
Fabrication of localized surface plasmon resonance fiber probes using ionic self-assembled gold nanoparticles. Sensors (Basel, Switzerland)\| PubMed ID: 22163561	2010
Identification of small molecule inhibitors of neurite loss induced by AÎ² peptide using high-content screening. The Journal of biological chemistry\| PubMed ID: 22277654	2012