Diabetes Research Institute
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Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism.
Diabetes Oct, 2003 | Pubmed ID: 14514636
On-line monitoring of apoptosis in insulin-secreting cells.
Diabetes Dec, 2003 | Pubmed ID: 14633855
Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat.
American journal of physiology. Endocrinology and metabolism Jan, 2002 | Pubmed ID: 11739091
Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis.
The Journal of biological chemistry May, 2002 | Pubmed ID: 11859087
Down-regulated expression of exocytotic proteins in pancreatic islets of diabetic GK rats.
Biochemical and biophysical research communications Mar, 2002 | Pubmed ID: 11866470
Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25.
Diabetes May, 2002 | Pubmed ID: 11978639
Inositol hexakisphosphate promotes dynamin I- mediated endocytosis.
Proceedings of the National Academy of Sciences of the United States of America May, 2002 | Pubmed ID: 12011438
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.
The Journal of biological chemistry Oct, 2002 | Pubmed ID: 12149271
Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis.
The Journal of biological chemistry Nov, 2002 | Pubmed ID: 12205083
Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.
FEBS letters Nov, 2002 | Pubmed ID: 12417312
Phosphorylated inositol compounds in beta -cell stimulus-response coupling.
American journal of physiology. Endocrinology and metabolism Dec, 2002 | Pubmed ID: 12424101
Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic beta-cells.
Endocrinology Dec, 2002 | Pubmed ID: 12446586
Insulin feedback action on pancreatic beta-cell function.
FEBS letters Dec, 2002 | Pubmed ID: 12459452
Two generations of insulinotropic imidazoline compounds.
Diabetes Dec, 2002 | Pubmed ID: 12475789
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
The Journal of general physiology Mar, 2003 | Pubmed ID: 12601083
Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis.
American journal of physiology. Endocrinology and metabolism Aug, 2003 | Pubmed ID: 12684219
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2003 | Pubmed ID: 12700357
Involvement of protein kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic beta-cells.
The Journal of biological chemistry Sep, 2003 | Pubmed ID: 12837755
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
Developmental cell Jul, 2003 | Pubmed ID: 12852853
Dihydroxyacetone-induced oscillations in cytoplasmic free Ca2+ and the ATP/ADP ratio in pancreatic beta-cells at substimulatory glucose.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12917415
Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis.
The Journal of biological chemistry Nov, 2003 | Pubmed ID: 12941947
Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration.
The Journal of biological chemistry Nov, 2003 | Pubmed ID: 12963730
Isoform-specific insulin receptor signaling involves different plasma membrane domains.
The Journal of cell biology Dec, 2003 | Pubmed ID: 14691140
Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation.
Molecular endocrinology (Baltimore, Md.) Jul, 2004 | Pubmed ID: 15056730
Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.
The Journal of biological chemistry Jul, 2004 | Pubmed ID: 15123626
Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2004 | Pubmed ID: 15210953
Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells.
Biochemical and biophysical research communications Jul, 2004 | Pubmed ID: 15240107
Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
Molecular endocrinology (Baltimore, Md.) Jan, 2005 | Pubmed ID: 15459251
Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis.
Cell Oct, 2004 | Pubmed ID: 15479643
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
Diabetes Dec, 2004 | Pubmed ID: 15561909
Beta-cell CaV channel regulation in physiology and pathophysiology.
American journal of physiology. Endocrinology and metabolism Jan, 2005 | Pubmed ID: 15585596
CaV2.3 channel and PKClambda: new players in insulin secretion.
The Journal of clinical investigation Jan, 2005 | Pubmed ID: 15630435
DARPP-32 and inhibitor-1 are expressed in pancreatic beta-cells.
Biochemical and biophysical research communications Apr, 2005 | Pubmed ID: 15737638
Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Endocrinology Jul, 2005 | Pubmed ID: 15831571
Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.
Brain research. Molecular brain research Aug, 2005 | Pubmed ID: 15908038
A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Jul, 2005 | Pubmed ID: 15943621
Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2005 | Pubmed ID: 16014415
Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts.
Diabetes Aug, 2005 | Pubmed ID: 16046293
Pancreatic islet function in a transgenic mouse expressing fluorescent protein.
The Journal of endocrinology Aug, 2005 | Pubmed ID: 16079259
A SIRTain role in pancreatic beta cell function.
Cell metabolism Aug, 2005 | Pubmed ID: 16098824
Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells.
Biochemical and biophysical research communications Dec, 2005 | Pubmed ID: 16277977
Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2005 | Pubmed ID: 16286652
Sirt1: a metabolic master switch that modulates lifespan.
Nature medicine Jan, 2006 | Pubmed ID: 16397557
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2006 | Pubmed ID: 16461897
Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis.
Diabetes Mar, 2006 | Pubmed ID: 16505218
Novel aspects on signal-transduction in the pancreatic beta-cell.
Nutrition, metabolism, and cardiovascular diseases : NMCD Mar, 2006 | Pubmed ID: 16530130
The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology.
Endocrine reviews Oct, 2006 | Pubmed ID: 16868246
RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.
Biochemical and biophysical research communications Sep, 2006 | Pubmed ID: 16870144
Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth.
Diabetes Dec, 2006 | Pubmed ID: 17130473
Selective gene activation by spatial segregation of insulin receptor B signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2007 | Pubmed ID: 17264162
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.
Nature cell biology Apr, 2007 | Pubmed ID: 17369816
Implantation site-dependent dysfunction of transplanted pancreatic islets.
Diabetes Jun, 2007 | Pubmed ID: 17400931
Tissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretion.
American journal of physiology. Endocrinology and metabolism Sep, 2007 | Pubmed ID: 17595219
An autocrine insulin feedback loop maintains pancreatic beta-cell 3-phosphorylated inositol lipids.
Molecular endocrinology (Baltimore, Md.) Nov, 2007 | Pubmed ID: 17652185
3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1).
FEBS letters Aug, 2007 | Pubmed ID: 17686476
Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model.
Transplantation Aug, 2007 | Pubmed ID: 17700154
Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules.
Cell metabolism Sep, 2007 | Pubmed ID: 17767908
Distribution of intraportally implanted microspheres and fluorescent islets in mice.
Cell transplantation , 2007 | Pubmed ID: 17912953
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells.
Science (New York, N.Y.) Nov, 2007 | Pubmed ID: 18033884
A key role for phosphorylated inositol compounds in pancreatic beta-cell stimulus-secretion coupling.
Advances in enzyme regulation , 2008 | Pubmed ID: 18194673
Noninvasive in vivo imaging of pancreatic islet cell biology.
Nature medicine May, 2008 | Pubmed ID: 18327249
Professor Rolf Luft, 1914--2007.
Diabetologia May, 2008 | Pubmed ID: 18327565
Automated, high-throughput assays for evaluation of human pancreatic islet function.
Cell transplantation , 2008 | Pubmed ID: 18351020
Proteins in the insulin-secreting cell line MIN6 bind the imidazoline compound BL11282.
FEBS letters May, 2008 | Pubmed ID: 18420036
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function.
Proceedings of the National Academy of Sciences of the United States of America May, 2008 | Pubmed ID: 18480258
Insulin signaling in the pancreatic beta-cell.
Annual review of nutrition , 2008 | Pubmed ID: 18481923
Glutamate is a positive autocrine signal for glucagon release.
Cell metabolism Jun, 2008 | Pubmed ID: 18522835
Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation.
Experimental diabetes research , 2008 | Pubmed ID: 18566681
Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye.
Nature protocols , 2008 | Pubmed ID: 18714296
An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function.
PLoS genetics Nov, 2008 | Pubmed ID: 19043548
Suramin inhibits the CD40-CD154 costimulatory interaction: a possible mechanism for immunosuppressive effects.
Biochemical pharmacology Apr, 2009 | Pubmed ID: 19283894
Beneficial role of pancreatic microenvironment for angiogenesis in transplanted pancreatic islets.
Cell transplantation , 2009 | Pubmed ID: 19476206
Diphosphoinositol pentakisphosphate as a novel mediator of insulin exocytosis.
Advances in enzyme regulation , 2009 | Pubmed ID: 19534030
Inositol pyrophosphates: structure, enzymology and function.
Cellular and molecular life sciences : CMLS Dec, 2009 | Pubmed ID: 19714294
Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death.
Cellular and molecular life sciences : CMLS Dec, 2009 | Pubmed ID: 19763396
Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats.
Microbiology and immunology Oct, 2009 | Pubmed ID: 19780970
Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release.
Diabetes Jan, 2010 | Pubmed ID: 19833886
Lipotoxicity and decreased islet graft survival.
Diabetes care Mar, 2010 | Pubmed ID: 20009097
Pulling force generated by interacting SNAREs facilitates membrane hemifusion.
Integrative biology : quantitative biosciences from nano to macro Apr, 2009 | Pubmed ID: 20023730
Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2010 | Pubmed ID: 20061534
Cholinergic augmentation of insulin release requires ankyrin-B.
Science signaling , 2010 | Pubmed ID: 20234002
ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2010 | Pubmed ID: 20308565
Novel aspects on pancreatic beta-cell signal-transduction.
Biochemical and biophysical research communications May, 2010 | Pubmed ID: 20494121
The role of inositol and the principles of labelling, extraction, and analysis of inositides in mammalian cells.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20645178
HPLC separation of inositol polyphosphates.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20645179
Diphosphosinositol polyphosphates and energy metabolism: assay for ATP/ADP ratio.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20645185
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action.
Cell metabolism Sep, 2010 | Pubmed ID: 20816090
Electrical short-circuit in β-cells from a patient with non-insulinoma pancreatogenous hypoglycemic syndrome (NIPHS): a case report.
Journal of medical case reports , 2010 | Pubmed ID: 20863385
Short telomeres compromise β-cell signaling and survival.
PloS one , 2011 | Pubmed ID: 21423765
Lowering apolipoprotein CIII delays onset of type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2011 | Pubmed ID: 21670290
Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans.
Nature medicine Jul, 2011 | Pubmed ID: 21685896
Munc18-1 and Munc18-2 proteins modulate beta-cell Ca2+ sensitivity and kinetics of insulin exocytosis differently.
The Journal of biological chemistry Aug, 2011 | Pubmed ID: 21690086
Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway.
Endocrinology Aug, 2011 | Pubmed ID: 21693679
Innervation patterns of autonomic axons in the human endocrine pancreas.
Cell metabolism Jul, 2011 | Pubmed ID: 21723503
High-resolution, noninvasive longitudinal live imaging of immune responses.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2011 | Pubmed ID: 21768391
Donor islet endothelial cells in pancreatic islet revascularization.
Diabetes Oct, 2011 | Pubmed ID: 21873551
Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell.
Cellular and molecular life sciences : CMLS May, 2012 | Pubmed ID: 22183612
One-step purification of functional human and rat pancreatic alpha cells.
Integrative biology : quantitative biosciences from nano to macro Feb, 2012 | Pubmed ID: 22267247
Markedly decreased blood perfusion of pancreatic islets transplanted intraportally into the liver: disruption of islet integrity necessary for islet revascularization.
Diabetes Mar, 2012 | Pubmed ID: 22315321
Real-time detection of acetylcholine release from the human endocrine pancreas.
Nature protocols Jun, 2012 | Pubmed ID: 22555241
Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells.
The Journal of biological chemistry Aug, 2012 | Pubmed ID: 22718751
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2012 | Pubmed ID: 22778403
The pancreatic beta cell as a paradigm for advances in inositide research.
Advances in biological regulation Sep, 2012 | Pubmed ID: 22884029
Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.
Acta neuropathologica Jan, 2013 | Pubmed ID: 22996963
The pancreatic islet as a signaling hub.
Advances in biological regulation Jan, 2013 | Pubmed ID: 23073565
Glucagon regulates its own synthesis by autocrine signaling.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2012 | Pubmed ID: 23213228
Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2012 | Pubmed ID: 23236142
Emodin Regulates Glucose Utilization by Activating AMP-activated Protein Kinase.
The Journal of biological chemistry Feb, 2013 | Pubmed ID: 23303186
C1-Ten is a Protein Tyrosine Phosphatase of IRS-1, Regulating IRS-1 Stability and Muscle Atrophy.
Molecular and cellular biology Feb, 2013 | Pubmed ID: 23401856
New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic β-Cell.
Pharmacological reviews , 2013 | Pubmed ID: 23429059
Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action.
PloS one , 2013 | Pubmed ID: 23451233
Control of insulin secretion by cholinergic signaling in the human pancreatic islet.
Diabetes Aug, 2014 | Pubmed ID: 24658304
Defects in β-cell Ca2+ dynamics in age-induced diabetes.
Diabetes Dec, 2014 | Pubmed ID: 24985350
β-Cell Ca(2+) dynamics and function are compromised in aging.
Advances in biological regulation Jan, 2015 | Pubmed ID: 25282681
Young capillary vessels rejuvenate aged pancreatic islets.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2014 | Pubmed ID: 25404292
Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice.
Nature medicine Jan, 2015 | Pubmed ID: 25569545
Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes.
Proceedings of the National Academy of Sciences of the United States of America May, 2015 | Pubmed ID: 25941406
The pancreatic β-cell in deadly encounter with apolipoprotein CIII.
Cell cycle (Georgetown, Tex.) , 2015 | Pubmed ID: 26102210
New insights into the architecture of the islet of Langerhans: a focused cross-species assessment.
Diabetologia Oct, 2015 | Pubmed ID: 26215305
Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets.
Diabetologia Dec, 2015 | Pubmed ID: 26376795
PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation.
Cell reports Oct, 2015 | Pubmed ID: 26387957
The anterior chamber of the eye is a transplantation site that supports and enables visualisation of beta cell development in mice.
Diabetologia May, 2016 | Pubmed ID: 26847769
Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model.
Cell metabolism Mar, 2016 | Pubmed ID: 26876561
Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells.
Cell reports Dec, 2016 | Pubmed ID: 28009296
Preservation of Anticancer and Immunosuppressive Properties of Rapamycin Achieved Through Controlled Releasing Particles.
AAPS PharmSciTech Oct, 2017 | Pubmed ID: 28251512
A novel toolbox to investigate tissue spatial organization applied to the study of the islets of Langerhans.
Scientific reports Mar, 2017 | Pubmed ID: 28303903
Pancreatic Islet Blood Flow Dynamics in Primates.
Cell reports Aug, 2017 | Pubmed ID: 28793270
Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes.
Scientific reports Sep, 2017 | Pubmed ID: 28963457
Protein kinase- and lipase inhibitors of inositide metabolism deplete IP indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity.
Cellular signalling Jan, 2018 | Pubmed ID: 29042286
Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point.
Cell metabolism Mar, 2018 | Pubmed ID: 29514065
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
Cellular signalling Jun, 2018 | Pubmed ID: 29522819
Corrigendum to 'Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells' [Cellular Signalling 46 (2018) 120-128].
Cellular signalling May, 2018 | Pubmed ID: 29807098
Blocking Ca Channel β Subunit Reverses Diabetes.
Cell reports Jul, 2018 | Pubmed ID: 30044988
Evidence for Ca(2+)-regulated ATP release in gastrointestinal stromal tumors.
Experimental cell research May, 2013 | Pubmed ID: 23499741
Islet inflammation in plain sight.
Diabetes, obesity & metabolism Sep, 2013 | Pubmed ID: 24003927
Reporter islets in the eye reveal the plasticity of the endocrine pancreas.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2013 | Pubmed ID: 24248353
aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.
PloS one , 2014 | Pubmed ID: 24416430
Short and prolonged exposure to hyperglycaemia in human fibroblasts and endothelial cells: metabolic and osmotic effects.
The international journal of biochemistry & cell biology Aug, 2014 | Pubmed ID: 24814290
Contribution of endothelial injury and inflammation in early phase to vein graft failure: the causal factors impact on the development of intimal hyperplasia in murine models.
PloS one , 2014 | Pubmed ID: 24887332
Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.
Nature communications , 2014 | Pubmed ID: 25374274
Secretome protein signature of human gastrointestinal stromal tumor cells.
Experimental cell research Aug, 2015 | Pubmed ID: 25983130
Pancreatic Islet Survival and Engraftment Is Promoted by Culture on Functionalized Spider Silk Matrices.
PloS one , 2015 | Pubmed ID: 26090859
Glucose intolerance and pancreatic β-cell dysfunction in the anorectic anx/anx mouse.
American journal of physiology. Endocrinology and metabolism Aug, 2015 | Pubmed ID: 26126683
Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins.
PLoS genetics Sep, 2015 | Pubmed ID: 26352669
ARA290 Improves Insulin Release and Glucose Tolerance in Type 2 Diabetic Goto-Kakizaki Rats.
Molecular medicine (Cambridge, Mass.) May, 2016 | Pubmed ID: 26736179
TLR3-/4-Priming Differentially Promotes Ca(2+) Signaling and Cytokine Expression and Ca(2+)-Dependently Augments Cytokine Release in hMSCs.
Scientific reports Mar, 2016 | Pubmed ID: 26980664
Silk matrices promote formation of insulin-secreting islet-like clusters.
Biomaterials Jun, 2016 | Pubmed ID: 26986856
The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition.
Investigational new drugs Aug, 2016 | Pubmed ID: 27221730
Diabetes Prevention Through Antiviral Treatment in Biobreeding Rats.
Viral immunology Oct, 2016 | Pubmed ID: 27505258
The Different Faces of the Pancreatic Islet.
Advances in experimental medicine and biology , 2016 | Pubmed ID: 27586419
Apolipoprotein CIII is a new player in diabetes.
Current opinion in lipidology Feb, 2017 | Pubmed ID: 27875339
Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways.
Scientific reports Dec, 2017 | Pubmed ID: 29259227
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.
Cell metabolism Feb, 2018 | Pubmed ID: 29414686
miR-31 regulates energy metabolism and is suppressed in T cells from patients with Sjögren's syndrome.
European journal of immunology Feb, 2019 | Pubmed ID: 30307034
Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat.
Laboratory animal research Sep, 2018 | Pubmed ID: 30310409
The eye as a novel imaging site in diabetes research.
Pharmacology & therapeutics May, 2019 | Pubmed ID: 30677477
Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.
Diabetologia 05, 2019 | Pubmed ID: 30701283
Inositol pyrophosphates and Akt/PKB: Is the pancreatic β-cell the exception to the rule?
Cellular signalling Jun, 2019 | Pubmed ID: 30742888
Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye.
Scientific reports Mar, 2019 | Pubmed ID: 30850640
Assembly of functionalized silk together with cells to obtain proliferative 3D cultures integrated in a network of ECM-like microfibers.
Scientific reports Apr, 2019 | Pubmed ID: 31000733
In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice.
Diabetologia Jul, 2019 | Pubmed ID: 31087105
Correction to: In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice.
Diabetologia Aug, 2019 | Pubmed ID: 31190158
Structural basis for delta cell paracrine regulation in pancreatic islets.
Nature communications Aug, 2019 | Pubmed ID: 31420552
Author Correction: Structural basis for delta cell paracrine regulation in pancreatic islets.
Nature communications Sep, 2019 | Pubmed ID: 31511521
Noninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours.
Scientific reports Oct, 2019 | Pubmed ID: 31601958
Intraocular Pressure Monitoring Following Islet Transplantation to the Anterior Chamber of the Eye.
Nano letters Mar, 2020 | Pubmed ID: 31750664
IgGs from patients with amyotrophic lateral sclerosis and diabetes target Caαδ1 subunits impairing islet cell function and survival.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2019 | Pubmed ID: 31826954
Enhanced expression of β cell Ca3.1 channels impairs insulin release and glucose homeostasis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2020 | Pubmed ID: 31871187
Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells.
Royal Society open science Jan, 2020 | Pubmed ID: 32218947
Platelet factor 4 enhances CD4 T effector memory cell responses via Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis.
Journal of thrombosis and haemostasis : JTH Oct, 2020 | Pubmed ID: 32671959
Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse.
eLife Jul, 2020 | Pubmed ID: 32696761
XPR1 Mediates the Pancreatic β-Cell Phosphate Flush.
Diabetes Jan, 2021 | Pubmed ID: 32826297
Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.
eLife Nov, 2020 | Pubmed ID: 33200981
Integration of Primary Endocrine Cells and Supportive Cells Using Functionalized Silk Promotes the Formation of Prevascularized Islet-like Clusters.
ACS biomaterials science & engineering Feb, 2020 | Pubmed ID: 33464872
Apolipoprotein CIII Is an Important Piece in the Type-1 Diabetes Jigsaw Puzzle.
International journal of molecular sciences Jan, 2021 | Pubmed ID: 33477763
Lowering apolipoprotein CIII protects against high-fat diet-induced metabolic derangements.
Science advances Mar, 2021 | Pubmed ID: 33712458
Tissue-specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models.
Journal of cellular and molecular medicine May, 2021 | Pubmed ID: 33742502
Challenges in stem cell-derived islet replacement therapy can be overcome.
Cell transplantation , 2021 | Pubmed ID: 34565192
Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive K channels.
Scientific reports Nov, 2021 | Pubmed ID: 34728728
An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation.
Nature communications Nov, 2021 | Pubmed ID: 34772928
Apolipoprotein CIII Reduction Protects White Adipose Tissues against Obesity-Induced Inflammation and Insulin Resistance in Mice.
International journal of molecular sciences Dec, 2021 | Pubmed ID: 35008488
Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells.
Cell transplantation , 2022 | Pubmed ID: 35156411
Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2022 | Pubmed ID: 35254894
Intravital Ca imaging of pancreatic β cell function after bariatric surgery.
Cell calcium Jun, 2022 | Pubmed ID: 35278937
Inward and outward currents of native and cloned K(ATP) channels (Kir6.2/SUR1) share single-channel kinetic properties.
Biochemistry and biophysics reports Jul, 2022 | Pubmed ID: 35434386
Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells.
Metabolism open Mar, 2022 | Pubmed ID: 35528374
Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis.
Cellular and molecular life sciences : CMLS May, 2022 | Pubmed ID: 35534740
Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII.
BioFactors (Oxford, England) Jan, 2023 | Pubmed ID: 36039858
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology.
Life science alliance Sep, 2022 | Pubmed ID: 36104081
Novel aspects of intra-islet communication: Primary cilia and filopodia.
Advances in biological regulation Jan, 2023 | Pubmed ID: 36266190
Drp1 Overexpression Decreases Insulin Content in Pancreatic MIN6 Cells.
International journal of molecular sciences Oct, 2022 | Pubmed ID: 36293194
ATF5 is a regulator of ER stress and β-cell apoptosis in different mouse models of genetic- and diet-induced obesity and diabetes mellitus.
Cellular signalling Nov, 2022 | Pubmed ID: 36436799
Uncommon Transplantation Sites: Transplantation of Islets and Islet Organoids in the Anterior Chamber of the Eye of Rodents and Monkeys.
Methods in molecular biology (Clifton, N.J.) , 2023 | Pubmed ID: 36507983
Longitudinal monitoring of pancreatic islet damage in streptozotocin-treated mice with optical coherence microscopy.
Biomedical optics express Jan, 2023 | Pubmed ID: 36698658
Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling.
Biomolecules May, 2023 | Pubmed ID: 37371464
1Diabetes Research Institute, University of Miami Miller School of Medicine,
2Department of Surgery, University of Miami Miller School of Medicine,
3Department of Medicine, University of Miami Miller School of Medicine,
4Department of Physiology & Biophysics, University of Miami Miller School of Medicine,
5The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet
Xiaofeng Zheng1,2,
Calvin Qing Wei Ho1,
Xiaowei Zheng3,
Kian Leong Lee4,
Katarina Gradin5,
Teresa S. Pereira3,
Per-Olof Berggren1,2,3,
Yusuf Ali1,2
1Lee Kong Chian School of Medicine, Nanyang Technological University,
2Singapore Eye Research Institute (SERI), Singapore General Hospital,
3The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital,
4Cancer and Stem Cell Biology Program, Duke-NUS Medical School,
5Department of Cell and Molecular Biology, Karolinska Institutet
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