Per-Olof Berggren

Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism.

On-line monitoring of apoptosis in insulin-secreting cells.

Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat.

Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis.

Down-regulated expression of exocytotic proteins in pancreatic islets of diabetic GK rats.

Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25.

Inositol hexakisphosphate promotes dynamin I- mediated endocytosis.

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.

Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis.

Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.

Phosphorylated inositol compounds in beta -cell stimulus-response coupling.

Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic beta-cells.

Insulin feedback action on pancreatic beta-cell function.

Two generations of insulinotropic imidazoline compounds.

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.

Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis.

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.

Involvement of protein kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic beta-cells.

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.

Dihydroxyacetone-induced oscillations in cytoplasmic free Ca2+ and the ATP/ADP ratio in pancreatic beta-cells at substimulatory glucose.

Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis.

Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration.

Isoform-specific insulin receptor signaling involves different plasma membrane domains.

Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation.

Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.

Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes.

Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells.

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.

Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis.

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.

Beta-cell CaV channel regulation in physiology and pathophysiology.

CaV2.3 channel and PKClambda: new players in insulin secretion.

DARPP-32 and inhibitor-1 are expressed in pancreatic beta-cells.

Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.

Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.

A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations.

Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta.

Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts.

Pancreatic islet function in a transgenic mouse expressing fluorescent protein.

A SIRTain role in pancreatic beta cell function.

Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells.

Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling.

Sirt1: a metabolic master switch that modulates lifespan.

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function.

Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis.

Novel aspects on signal-transduction in the pancreatic beta-cell.

The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology.

RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.

Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth.

Selective gene activation by spatial segregation of insulin receptor B signaling.

R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

Implantation site-dependent dysfunction of transplanted pancreatic islets.

Tissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretion.

An autocrine insulin feedback loop maintains pancreatic beta-cell 3-phosphorylated inositol lipids.

3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1).

Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model.

Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules.

Distribution of intraportally implanted microspheres and fluorescent islets in mice.

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells.

A key role for phosphorylated inositol compounds in pancreatic beta-cell stimulus-secretion coupling.

Noninvasive in vivo imaging of pancreatic islet cell biology.

Professor Rolf Luft, 1914--2007.

Automated, high-throughput assays for evaluation of human pancreatic islet function.

Proteins in the insulin-secreting cell line MIN6 bind the imidazoline compound BL11282.

Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function.

Insulin signaling in the pancreatic beta-cell.

Glutamate is a positive autocrine signal for glucagon release.

Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation.

Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye.

An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function.

Suramin inhibits the CD40-CD154 costimulatory interaction: a possible mechanism for immunosuppressive effects.

Beneficial role of pancreatic microenvironment for angiogenesis in transplanted pancreatic islets.

Diphosphoinositol pentakisphosphate as a novel mediator of insulin exocytosis.

Inositol pyrophosphates: structure, enzymology and function.

Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death.

Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats.

Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release.

Lipotoxicity and decreased islet graft survival.

Pulling force generated by interacting SNAREs facilitates membrane hemifusion.

Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion.

Cholinergic augmentation of insulin release requires ankyrin-B.

ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell.

Novel aspects on pancreatic beta-cell signal-transduction.

The role of inositol and the principles of labelling, extraction, and analysis of inositides in mammalian cells.

HPLC separation of inositol polyphosphates.

Diphosphosinositol polyphosphates and energy metabolism: assay for ATP/ADP ratio.

Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action.

Electrical short-circuit in β-cells from a patient with non-insulinoma pancreatogenous hypoglycemic syndrome (NIPHS): a case report.

Short telomeres compromise β-cell signaling and survival.

Lowering apolipoprotein CIII delays onset of type 1 diabetes.

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans.

Munc18-1 and Munc18-2 proteins modulate beta-cell Ca2+ sensitivity and kinetics of insulin exocytosis differently.

Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway.

Innervation patterns of autonomic axons in the human endocrine pancreas.

High-resolution, noninvasive longitudinal live imaging of immune responses.

Donor islet endothelial cells in pancreatic islet revascularization.

Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell.

One-step purification of functional human and rat pancreatic alpha cells.

Markedly decreased blood perfusion of pancreatic islets transplanted intraportally into the liver: disruption of islet integrity necessary for islet revascularization.

Real-time detection of acetylcholine release from the human endocrine pancreas.

Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells.

Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron.

The pancreatic beta cell as a paradigm for advances in inositide research.

Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.

The pancreatic islet as a signaling hub.

Glucagon regulates its own synthesis by autocrine signaling.

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function.

Emodin Regulates Glucose Utilization by Activating AMP-activated Protein Kinase.

C1-Ten is a Protein Tyrosine Phosphatase of IRS-1, Regulating IRS-1 Stability and Muscle Atrophy.

New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic β-Cell.

Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action.

Control of insulin secretion by cholinergic signaling in the human pancreatic islet.

Defects in β-cell Ca2+ dynamics in age-induced diabetes.

β-Cell Ca(2+) dynamics and function are compromised in aging.

Young capillary vessels rejuvenate aged pancreatic islets.

Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice.

Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes.

The pancreatic β-cell in deadly encounter with apolipoprotein CIII.

New insights into the architecture of the islet of Langerhans: a focused cross-species assessment.

Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets.

PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation.

The anterior chamber of the eye is a transplantation site that supports and enables visualisation of beta cell development in mice.

Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model.

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells.

Preservation of Anticancer and Immunosuppressive Properties of Rapamycin Achieved Through Controlled Releasing Particles.

A novel toolbox to investigate tissue spatial organization applied to the study of the islets of Langerhans.

Pancreatic Islet Blood Flow Dynamics in Primates.

Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes.

Protein kinase- and lipase inhibitors of inositide metabolism deplete IP indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity.

Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point.

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.

Corrigendum to 'Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells' [Cellular Signalling 46 (2018) 120-128].

Blocking Ca Channel β Subunit Reverses Diabetes.

Evidence for Ca(2+)-regulated ATP release in gastrointestinal stromal tumors.

Islet inflammation in plain sight.

Reporter islets in the eye reveal the plasticity of the endocrine pancreas.

aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.

Short and prolonged exposure to hyperglycaemia in human fibroblasts and endothelial cells: metabolic and osmotic effects.

Contribution of endothelial injury and inflammation in early phase to vein graft failure: the causal factors impact on the development of intimal hyperplasia in murine models.

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.

Secretome protein signature of human gastrointestinal stromal tumor cells.

Pancreatic Islet Survival and Engraftment Is Promoted by Culture on Functionalized Spider Silk Matrices.

Glucose intolerance and pancreatic β-cell dysfunction in the anorectic anx/anx mouse.

Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins.

ARA290 Improves Insulin Release and Glucose Tolerance in Type 2 Diabetic Goto-Kakizaki Rats.

TLR3-/4-Priming Differentially Promotes Ca(2+) Signaling and Cytokine Expression and Ca(2+)-Dependently Augments Cytokine Release in hMSCs.

Silk matrices promote formation of insulin-secreting islet-like clusters.

The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition.

Diabetes Prevention Through Antiviral Treatment in Biobreeding Rats.

The Different Faces of the Pancreatic Islet.

Apolipoprotein CIII is a new player in diabetes.

Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways.

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.

miR-31 regulates energy metabolism and is suppressed in T cells from patients with Sjögren's syndrome.

Neither polyphenol-rich red wine nor fenofibrate affects the onset of type-1 diabetes mellitus in the BB rat.

The eye as a novel imaging site in diabetes research.

Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.

Inositol pyrophosphates and Akt/PKB: Is the pancreatic β-cell the exception to the rule?

Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye.

Assembly of functionalized silk together with cells to obtain proliferative 3D cultures integrated in a network of ECM-like microfibers.

In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice.

Correction to: In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice.

Structural basis for delta cell paracrine regulation in pancreatic islets.

Author Correction: Structural basis for delta cell paracrine regulation in pancreatic islets.

Noninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours.

Intraocular Pressure Monitoring Following Islet Transplantation to the Anterior Chamber of the Eye.

IgGs from patients with amyotrophic lateral sclerosis and diabetes target Caαδ1 subunits impairing islet cell function and survival.

Enhanced expression of β cell Ca3.1 channels impairs insulin release and glucose homeostasis.

Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells.

Platelet factor 4 enhances CD4 T effector memory cell responses via Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis.

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse.

XPR1 Mediates the Pancreatic β-Cell Phosphate Flush.

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.

Integration of Primary Endocrine Cells and Supportive Cells Using Functionalized Silk Promotes the Formation of Prevascularized Islet-like Clusters.

Apolipoprotein CIII Is an Important Piece in the Type-1 Diabetes Jigsaw Puzzle.

Lowering apolipoprotein CIII protects against high-fat diet-induced metabolic derangements.

Tissue-specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models.

Challenges in stem cell-derived islet replacement therapy can be overcome.

Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive K channels.

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation.

Apolipoprotein CIII Reduction Protects White Adipose Tissues against Obesity-Induced Inflammation and Insulin Resistance in Mice.

Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells.

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.

Intravital Ca imaging of pancreatic β cell function after bariatric surgery.

Inward and outward currents of native and cloned K(ATP) channels (Kir6.2/SUR1) share single-channel kinetic properties.

Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells.

Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis.

Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII.

Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology.

Novel aspects of intra-islet communication: Primary cilia and filopodia.

Drp1 Overexpression Decreases Insulin Content in Pancreatic MIN6 Cells.

ATF5 is a regulator of ER stress and β-cell apoptosis in different mouse models of genetic- and diet-induced obesity and diabetes mellitus.

Uncommon Transplantation Sites: Transplantation of Islets and Islet Organoids in the Anterior Chamber of the Eye of Rodents and Monkeys.

Longitudinal monitoring of pancreatic islet damage in streptozotocin-treated mice with optical coherence microscopy.

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling.