David D. Shock

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain.

Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.

Rapid segmental and subdomain motions of DNA polymerase beta.

Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis.

Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.

DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair.

DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts.

Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.

Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.

Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta.

Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.

Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.

Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function.

DNA polymerase beta substrate specificity: side chain modulation of the "A-rule".

Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid.

Base excision repair and design of small molecule inhibitors of human DNA polymerase β.

Substrate channeling in mammalian base excision repair pathways: passing the baton.

Metal-induced DNA translocation leads to DNA polymerase conformational activation.

Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion.

Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β.

Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.

Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction.

Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.

Observing a DNA polymerase choose right from wrong.