Leonardo Sacconi

European Laboratory for Non-linear Spectroscopy (LENS)

Affiliated withEuropean Laboratory for Non-linear Spectroscopy (LENS)National Institute of Optics (CNR-INO)University of Florence

Research Area

NeuroscienceBiology

Biography

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JoVE Journal Publications

Article Total : 3	Year
Publication title	2013
Publication title	2014
Publication title	2021

Other Publications

Article	Year
Positioning and elongation of the fission yeast spindle by microtubule-based pushing. Current biology : CB\| PubMed ID: 15242615	2004
Optical micromanipulations inside yeast cells. Applied optics\| PubMed ID: 15835347	2005
Combined intracellular three-dimensional imaging and selective nanosurgery by a nonlinear microscope. Journal of biomedical optics\| PubMed ID: 15847583	2005
Nuclear and division-plane positioning revealed by optical micromanipulation. Current biology : CB\| PubMed ID: 16005294	2005
Optical recording of fast neuronal membrane potential transients in acute mammalian brain slices by second-harmonic generation microscopy. Journal of neurophysiology\| PubMed ID: 16093337	2005
Lac repressor hinge flexibility and DNA looping: single molecule kinetics by tethered particle motion. Nucleic acids research\| PubMed ID: 16835309	2006
Cell imaging and manipulation by nonlinear optical microscopy. Cell biochemistry and biophysics\| PubMed ID: 16845175	2006
In vivo multiphoton nanosurgery on cortical neurons. Journal of biomedical optics\| PubMed ID: 17994859	2007
Optical recording of electrical activity in intact neuronal networks with random access second-harmonic generation microscopy. Optics express\| PubMed ID: 18795028	2008
Multi-photon nanosurgery in live brain. Frontiers in neuroenergetics\| PubMed ID: 20725602	2010
Action potential propagation in transverse-axial tubular system is impaired in heart failure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22451916	2012
Protein conformation and molecular order probed by second-harmonic-generation microscopy. Journal of biomedical optics\| PubMed ID: 22734730	2012
Palette of fluorinated voltage-sensitive hemicyanine dyes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23169660	2012
Two-photon microscopy imaging of thy1GFP-M transgenic mice: a novel animal model to investigate brain dendritic cell subsets in vivo. PloS one\| PubMed ID: 23409142	2013
In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23754371	2013
Correlative two-photon and light sheet microscopy. Methods (San Diego, Calif.)\| PubMed ID: 23806642	2013
The connectomics challenge. Functional neurology\| PubMed ID: 24139653	2013
Impact of detubulation on force and kinetics of cardiac muscle contraction. The Journal of general physiology\| PubMed ID: 24863933	2014
Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25288764	2014
Functional cardiac imaging by random access microscopy. Frontiers in physiology\| PubMed ID: 25368580	2014
Towards a comprehensive understanding of brain machinery by correlative microscopy. Journal of biomedical optics\| PubMed ID: 25749101	2015
A versatile clearing agent for multi-modal brain imaging. Scientific reports\| PubMed ID: 25950610	2015
Comprehensive optical and data management infrastructure for high-throughput light-sheet microscopy of whole mouse brains. Neurophotonics\| PubMed ID: 26158018	2015
Multi-Modal Optical Imaging of the Cerebellum in Animals. Cerebellum (London, England)\| PubMed ID: 26476852	2016
Label-free near-infrared reflectance microscopy as a complimentary tool for two-photon fluorescence brain imaging. Biomedical optics express\| PubMed ID: 26601011	2015
Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 26714042	2016
Clearing of fixed tissue: a review from a microscopist's perspective. Journal of biomedical optics\| PubMed ID: 27020691	2016
T-Tubular Electrical Defects Contribute to Blunted β-Adrenergic Response in Heart Failure. International journal of molecular sciences\| PubMed ID: 27598150	2016
Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation. Scientific reports\| PubMed ID: 27748433	2016
Electrical defects of the transverse-axial tubular system in cardiac diseases. The Journal of physiology\| PubMed ID: 27981580	2017
Optogenetics gets to the heart: A guiding light beyond defibrillation. Progress in biophysics and molecular biology\| PubMed ID: 28506694	2017
Quantitative assessment of passive electrical properties of the cardiac T-tubular system by FRAP microscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28507142	2017
Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 29045016	2017
Reply to Entcheva: The impact of T-tubules on action potential propagation in cardiac tissue. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29305385	2018
Confocal multispot microscope for fast and deep imaging in semicleared tissues. Journal of biomedical optics\| PubMed ID: 29460510	2018
Whole-Brain Vasculature Reconstruction at the Single Capillary Level. Scientific reports\| PubMed ID: 30135559	2018
Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy. Frontiers in cellular neuroscience\| PubMed ID: 30294262	2018
Axial Tubule Junctions Activate Atrial Ca Release Across Species. Frontiers in physiology\| PubMed ID: 30349482	2018
Interplay Between Sub-Cellular Alterations of Calcium Release and T-Tubular Defects in Cardiac Diseases. Frontiers in physiology\| PubMed ID: 30410446	2018
High-Fidelity Imaging in Brain-Wide Structural Studies Using Light-Sheet Microscopy. eNeuro\| PubMed ID: 30627630	2018
Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac Contraction. Circulation research\| PubMed ID: 30732554	2019
Corrigendum: Bessel Beam Illumination Reduces Random and Systematic Errors in Quantitative Functional Studies Using Light-Sheet Microscopy. Frontiers in cellular neuroscience\| PubMed ID: 30853897	2019
Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery. The Journal of physiology\| PubMed ID: 31116413	2019
A Software Architecture to Mimic a Ventricular Tachycardia in Intact Murine Hearts by Means of an All-Optical Platform. Methods and protocols\| PubMed ID: 31164591	2019
Publisher Correction: Whole-Brain Vasculature Reconstruction at the Single Capillary Level. Scientific reports\| PubMed ID: 31201354	2019
Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks after Stroke. Cell reports\| PubMed ID: 31553915	2019
Novel optics-based approaches for cardiac electrophysiology. Progress in biophysics and molecular biology\| PubMed ID: 32407749	2020
3D imaging and morphometry of the heart capillary system in spontaneously hypertensive rats and normotensive controls. Scientific reports\| PubMed ID: 32868776	2020
Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange. Circulation research\| PubMed ID: 33228470	2021
Arrhythmogenic potential of myocardial disarray in hypertrophic cardiomyopathy: genetic basis, functional consequences and relation to sudden cardiac death. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 33447843	2021
Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination. eLife\| PubMed ID: 33502313	2021
Optical clearing in cardiac imaging: A comparative study. Progress in biophysics and molecular biology\| PubMed ID: 34358555	2021
Fast Optical Investigation of Cardiac Electrophysiology by Parallel Detection in Multiwell Plates. Frontiers in physiology\| PubMed ID: 34539428	2021