Bioanalytical Mass Spectrometry Group
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A two-tracked approach to analyze RNA-protein crosslinking sites in native, nonlabeled small nuclear ribonucleoprotein particles.
Methods (San Diego, Calif.) Feb, 2002 | Pubmed ID: 12054894
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.
Cell Sep, 2002 | Pubmed ID: 12230974
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.
The EMBO journal Sep, 2002 | Pubmed ID: 12234937
Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins.
The EMBO journal Oct, 2002 | Pubmed ID: 12374753
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.
Science (New York, N.Y.) Dec, 2002 | Pubmed ID: 12411573
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12477934
An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains.
Proceedings of the National Academy of Sciences of the United States of America May, 2003 | Pubmed ID: 12719542
Mutagenesis suggests several roles of Snu114p in pre-mRNA splicing.
The Journal of biological chemistry Jul, 2003 | Pubmed ID: 12736260
Analysis of mammalian gene function using small interfering RNAs.
Nucleic acids research. Supplement (2001) , 2003 | Pubmed ID: 14510516
The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module.
Structure (London, England : 1993) Nov, 2003 | Pubmed ID: 14604529
Analysis of site-specific protein-RNA cross-links in isolated RNP complexes, combining affinity selection and mass spectrometry.
RNA (New York, N.Y.) Dec, 2003 | Pubmed ID: 14624009
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
RNA (New York, N.Y.) Jun, 2004 | Pubmed ID: 15146077
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing.
The EMBO journal Jun, 2004 | Pubmed ID: 15175653
Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding.
The Biochemical journal Nov, 2004 | Pubmed ID: 15279620
Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1.
Acta crystallographica. Section D, Biological crystallography Sep, 2004 | Pubmed ID: 15333938
Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex.
Molecular cell Dec, 2004 | Pubmed ID: 15574333
Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells.
Microbiology (Reading, England) Jan, 2005 | Pubmed ID: 15632438
Proteomic analysis of reaper 5' untranslated region-interacting factors isolated by tobramycin affinity-selection reveals a role for La antigen in reaper mRNA translation.
Proteomics Apr, 2005 | Pubmed ID: 15789343
Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila.
Mechanisms of development Apr, 2005 | Pubmed ID: 15804566
Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.
The Journal of biological chemistry Sep, 2005 | Pubmed ID: 16006558
Identification of novel argonaute-associated proteins.
Current biology : CB Dec, 2005 | Pubmed ID: 16289642
Complete MALDI-ToF MS analysis of cross-linked peptide-RNA oligonucleotides derived from nonlabeled UV-irradiated ribonucleoprotein particles.
RNA (New York, N.Y.) Dec, 2005 | Pubmed ID: 16314460
DDX6 recruits translational silenced human reticulocyte 15-lipoxygenase mRNA to RNP granules.
RNA (New York, N.Y.) Nov, 2010 | Pubmed ID: 20884783
RNA structure and RNA-protein interactions in purified yeast U6 snRNPs.
Journal of molecular biology Mar, 2006 | Pubmed ID: 16410014
Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.
The Journal of biological chemistry Jun, 2006 | Pubmed ID: 16621800
Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase.
RNA (New York, N.Y.) Aug, 2006 | Pubmed ID: 16790842
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.
Molecular and cellular biology Jul, 2006 | Pubmed ID: 16809785
The Methanothermobacter thermautotrophicus ExoIII homologue Mth212 is a DNA uridine endonuclease.
Nucleic acids research , 2006 | Pubmed ID: 17012282
Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.
RNA (New York, N.Y.) Jan, 2007 | Pubmed ID: 17095540
Molecular anatomy of a trafficking organelle.
Cell Nov, 2006 | Pubmed ID: 17110340
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.
Nature cell biology Jan, 2007 | Pubmed ID: 17173041
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.
The EMBO journal Mar, 2007 | Pubmed ID: 17332742
Detection of protein-RNA crosslinks by NanoLC-ESI-MS/MS using precursor ion scanning and multiple reaction monitoring (MRM) experiments.
Journal of the American Society for Mass Spectrometry May, 2007 | Pubmed ID: 17349801
In vitro RNA editing in plant mitochondria does not require added energy.
FEBS letters Jun, 2007 | Pubmed ID: 17531229
Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2007 | Pubmed ID: 17601773
Improved identification of enriched peptide RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry.
Nucleic acids research , 2007 | Pubmed ID: 17652325
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
EMBO reports Nov, 2007 | Pubmed ID: 17932509
Two DEAD-box proteins may be part of RNA-dependent high-molecular-mass protein complexes in Arabidopsis mitochondria.
Plant physiology Dec, 2007 | Pubmed ID: 17951454
GraFix: sample preparation for single-particle electron cryomicroscopy.
Nature methods Jan, 2008 | Pubmed ID: 18157137
'Proteomic basics--sample preparation and separation': the 1st European Summer School in Kloster Neustift, 12-18 August, 2007 Brixen/Bressanone, South Tyrol, Italy.
Proteomics Jan, 2008 | Pubmed ID: 18203264
Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity.
Molecular and cellular biology Apr, 2008 | Pubmed ID: 18285457
Isolation of an active step I spliceosome and composition of its RNP core.
Nature Apr, 2008 | Pubmed ID: 18322460
CASK Functions as a Mg2+-independent neurexin kinase.
Cell Apr, 2008 | Pubmed ID: 18423203
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.
Nature structural & molecular biology May, 2008 | Pubmed ID: 18425142
Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.
Molecular cell Jun, 2008 | Pubmed ID: 18538659
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes.
Molecular and cellular biology Jan, 2009 | Pubmed ID: 18981222
Analyzing RNA-protein crosslinking sites in unlabeled ribonucleoprotein complexes by mass spectrometry.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 18982295
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation.
RNA (New York, N.Y.) Jan, 2009 | Pubmed ID: 19029308
Structure of tripeptidyl-peptidase I provides insight into the molecular basis of late infantile neuronal ceroid lipofuscinosis.
The Journal of biological chemistry Feb, 2009 | Pubmed ID: 19038966
SAP18 promotes Krüppel-dependent transcriptional repression by enhancer-specific histone deacetylation.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 19049982
Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
Molecular cell Dec, 2008 | Pubmed ID: 19111659
Atmospheric pressure free liquid infrared MALDI mass spectrometry: toward a combined ESI/ MALDI-liquid chromatography interface.
Analytical chemistry Jan, 2009 | Pubmed ID: 19125446
The neuropeptidome of Rhodnius prolixus brain.
Proteomics Feb, 2009 | Pubmed ID: 19137558
Enrichment of protein-RNA crosslinks from crude UV-irradiated mixtures for MS analysis by on-line chromatography using titanium dioxide columns.
Biopolymers Apr, 2009 | Pubmed ID: 19140157
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.
Cell Feb, 2009 | Pubmed ID: 19167051
SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins.
Molecular & cellular proteomics : MCP Jul, 2009 | Pubmed ID: 19372136
iTRAQ-labeling of in-gel digested proteins for relative quantification.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19544025
SMN-assisted assembly of snRNP-specific Sm cores in trypanosomes.
Genes & development Jul, 2009 | Pubmed ID: 19605687
The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19667070
Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography.
BMC structural biology , 2009 | Pubmed ID: 19706171
"ChopNSpice," a mass spectrometric approach that allows identification of endogenous small ubiquitin-like modifier-conjugated peptides.
Molecular & cellular proteomics : MCP Dec, 2009 | Pubmed ID: 19721078
In vivo expression and purification of aptamer-tagged small RNA regulators.
Nucleic acids research Nov, 2009 | Pubmed ID: 19726584
Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19808672
A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells.
PloS one , 2009 | Pubmed ID: 19847302
The B-lymphoid Grb2 interaction code.
Immunological reviews Nov, 2009 | Pubmed ID: 19909361
Proteomic basics - Quantification and post-translational modifications of proteins: The 3rd European summer school in Kloster Neustift.
Journal of proteomics Nov, 2009 | Pubmed ID: 19931431
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components.
Nature structural & molecular biology Dec, 2009 | Pubmed ID: 19935684
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.
Molecular cell Nov, 2009 | Pubmed ID: 19941820
Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2010 | Pubmed ID: 20053882
Essential role of a trypanosome U4-specific Sm core protein in small nuclear ribonucleoprotein assembly and splicing.
Eukaryotic cell Mar, 2010 | Pubmed ID: 20081062
Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding.
Nature structural & molecular biology Feb, 2010 | Pubmed ID: 20118935
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
Nature structural & molecular biology Feb, 2010 | Pubmed ID: 20118938
Molecular architecture of the human Prp19/CDC5L complex.
Molecular and cellular biology May, 2010 | Pubmed ID: 20176811
A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.
The Journal of cell biology Feb, 2010 | Pubmed ID: 20176924
Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring.
Analytical chemistry Apr, 2010 | Pubmed ID: 20225856
Extraction of proteins from formalin-fixed, paraffin-embedded tissue using the Qproteome extraction technique and preparation of tryptic peptides for liquid chromatography/mass spectrometry analysis.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] Apr, 2010 | Pubmed ID: 20373500
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes.
Molecular cell Apr, 2010 | Pubmed ID: 20417601
Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry.
Nucleic acids research Sep, 2010 | Pubmed ID: 20421206
Merging molecular electron microscopy and mass spectrometry by carbon film-assisted endoproteinase digestion.
Molecular & cellular proteomics : MCP Aug, 2010 | Pubmed ID: 20530635
The archaeal Lsm protein binds to small RNAs.
The Journal of biological chemistry Nov, 2010 | Pubmed ID: 20826804
The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique.
Nucleic acids research Jan, 2011 | Pubmed ID: 20852261
Pseudo-neutral-loss scan for selective detection of phosphopeptides and N-glycopeptides using liquid chromatography coupled with a hybrid linear ion-trap/orbitrap mass spectrometer.
Proteomics Nov, 2010 | Pubmed ID: 20925059
Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2010 | Pubmed ID: 20926670
A novel Nop5-sRNA interaction that is required for efficient archaeal box C/D sRNP formation.
RNA (New York, N.Y.) Dec, 2010 | Pubmed ID: 20962039
Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.
RNA (New York, N.Y.) Dec, 2010 | Pubmed ID: 20980672
PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila.
Cell metabolism Nov, 2010 | Pubmed ID: 21035762
Phosphorylation of human Argonaute proteins affects small RNA binding.
Nucleic acids research Mar, 2011 | Pubmed ID: 21071408
7SK small nuclear RNA directly affects HMGA1 function in transcription regulation.
Nucleic acids research Mar, 2011 | Pubmed ID: 21087998
Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA.
The Journal of biological chemistry Mar, 2011 | Pubmed ID: 21220421
Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells.
Cellular signalling May, 2011 | Pubmed ID: 21262349
RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure.
Development (Cambridge, England) Apr, 2011 | Pubmed ID: 21350015
Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.
European journal of immunology Jun, 2011 | Pubmed ID: 21469132
A cytoplasmic complex mediates specific mRNA recognition and localization in yeast.
PLoS biology Apr, 2011 | Pubmed ID: 21526221
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method.
Molecular and cellular biology Jul, 2011 | Pubmed ID: 21536652
Functional proteomics of neuropeptidome dynamics during the feeding process of Rhodnius prolixus.
Journal of proteome research Aug, 2011 | Pubmed ID: 21699238
B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.
Immunity Jun, 2011 | Pubmed ID: 21703542
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.
The EMBO journal Aug, 2011 | Pubmed ID: 21725281
Sumoylation inhibits alpha-synuclein aggregation and toxicity.
The Journal of cell biology Jul, 2011 | Pubmed ID: 21746851
Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation.
Developmental biology Sep, 2011 | Pubmed ID: 21782810
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.
The EMBO journal Aug, 2011 | Pubmed ID: 21822214
Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns.
Molecular & cellular proteomics : MCP Nov, 2011 | Pubmed ID: 21836164
A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching.
Nature biotechnology Oct, 2011 | Pubmed ID: 21909082
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis.
The EMBO journal Nov, 2011 | Pubmed ID: 21983901
Phosphorylation site localization in peptides by MALDI MS/MS and the Mascot Delta Score.
Analytical and bioanalytical chemistry Jan, 2012 | Pubmed ID: 22038583
MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.
Molecular biology of the cell Jan, 2012 | Pubmed ID: 22114354
BC1-FMRP interaction is modulated by 2'-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses.
Nucleic acids research May, 2012 | Pubmed ID: 22238374
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity.
Immunity Jan, 2012 | Pubmed ID: 22265677
Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis.
Annals of neurology Feb, 2012 | Pubmed ID: 22367995
Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein.
The EMBO journal May, 2012 | Pubmed ID: 22407296
OKB, a novel family of brain-gut neuropeptides from insects.
Insect biochemistry and molecular biology Jul, 2012 | Pubmed ID: 22480496
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.
Nature structural & molecular biology May, 2012 | Pubmed ID: 22522823
The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling.
Molecular pharmacology Aug, 2012 | Pubmed ID: 22554804
Investigation of protein-RNA interactions by mass spectrometry--Techniques and applications.
Journal of proteomics Jun, 2012 | Pubmed ID: 22575267
Quantitative mass spectrometry-based proteomics: an overview.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22665296
Absolute quantification of proteins using standard peptides and multiple reaction monitoring.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22665306
Identification of endogenous SUMO1 accepter sites by mass spectrometry.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22665316
Determinants of interaction specificity of the Bacillus subtilis GlcT antitermination protein: functionality and phosphorylation specificity depend on the arrangement of the regulatory domains.
The Journal of biological chemistry Aug, 2012 | Pubmed ID: 22722928
Structure and activity of the only human RNase T2.
Nucleic acids research Sep, 2012 | Pubmed ID: 22735700
Biophysical properties and cellular toxicity of covalent crosslinked oligomers of α-synuclein formed by photoinduced side-chain tyrosyl radicals.
Free radical biology & medicine Aug, 2012 | Pubmed ID: 22771470
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion.
Nature communications , 2012 | Pubmed ID: 22871813
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.
EMBO reports Oct, 2012 | Pubmed ID: 22878415
The claudin Megatrachea protein complex.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22930751
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.
Genes & development Nov, 2012 | Pubmed ID: 23124066
The human cytomegalovirus DNA polymerase processivity factor UL44 is modified by SUMO in a DNA-dependent manner.
PloS one , 2012 | Pubmed ID: 23166733
Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes.
The EMBO journal Jan, 2013 | Pubmed ID: 23202855
Burial of the polymorphic residue 129 in amyloid fibrils of prion stop mutants.
The Journal of biological chemistry Feb, 2013 | Pubmed ID: 23209282
In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2012 | Pubmed ID: 23213215
The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23223229
EF-P is essential for rapid synthesis of proteins containing consecutive proline residues.
Science (New York, N.Y.) Jan, 2013 | Pubmed ID: 23239624
Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry.
Molecular & cellular proteomics : MCP Mar, 2013 | Pubmed ID: 23242554
Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.
PloS one , 2012 | Pubmed ID: 23285124
Identification of DEAD-box RNA helicase 6 (DDX6) as a cellular modulator of vascular endothelial growth factor expression under hypoxia.
The Journal of biological chemistry Feb, 2013 | Pubmed ID: 23293030
SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.
Nature cell biology Feb, 2013 | Pubmed ID: 23314863
Evolution of the protein stoichiometry in the L12 stalk of bacterial and organellar ribosomes.
Nature communications , 2013 | Pubmed ID: 23340427
Mass spectrometry imaging: linking molecule profiles to tissue spatial distribution.
Expert review of proteomics Feb, 2013 | Pubmed ID: 23414355
Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system.
Genes & development Feb, 2013 | Pubmed ID: 23431055
Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
Mitochondrion Nov, 2013 | Pubmed ID: 23438705
An automated in-gel digestion/iTRAQ-labeling workflow for robust quantification of gel-separated proteins.
Proteomics May, 2013 | Pubmed ID: 23456960
Detecting endogenous SUMO targets in mammalian cells and tissues.
Nature structural & molecular biology Apr, 2013 | Pubmed ID: 23503365
β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.
Blood May, 2013 | Pubmed ID: 23509157
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
Acta neuropathologica Jun, 2013 | Pubmed ID: 23604588
Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Neuron Apr, 2013 | Pubmed ID: 23622064
Mover is a homomeric phospho-protein present on synaptic vesicles.
PloS one , 2013 | Pubmed ID: 23723986
The nuclear F-actin interactome of Xenopus oocytes reveals an actin-bundling kinesin that is essential for meiotic cytokinesis.
The EMBO journal Jul, 2013 | Pubmed ID: 23727888
Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma.
Nature communications , 2013 | Pubmed ID: 23828504
Structural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions.
Nucleic acids research Sep, 2013 | Pubmed ID: 23851565
Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.
Cell reports Aug, 2013 | Pubmed ID: 23933260
Increased proteome coverage by combining PAGE and peptide isoelectric focusing: comparative study of gel-based separation approaches.
Proteomics Oct, 2013 | Pubmed ID: 23943586
The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation.
Molecular and cellular biology Oct, 2013 | Pubmed ID: 23979592
Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2013 | Pubmed ID: 24068818
The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9.
The Journal of biological chemistry Nov, 2013 | Pubmed ID: 24072711
Immunostimulatory activity of murine keratinocyte-derived exosomes.
Experimental dermatology Oct, 2013 | Pubmed ID: 24079734
Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex.
Nature structural & molecular biology Nov, 2013 | Pubmed ID: 24121231
Insights into the activation of the helicase Prp43 by biochemical studies and structural mass spectrometry.
Nucleic acids research Jan, 2014 | Pubmed ID: 24165877
Cutting edge: feed-forward activation of phospholipase Cγ2 via C2 domain-mediated binding to SLP65.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2013 | Pubmed ID: 24166973
Phosphorylation drives a dynamic switch in serine/arginine-rich proteins.
Structure (London, England : 1993) Dec, 2013 | Pubmed ID: 24183573
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
The EMBO journal Jan, 2014 | Pubmed ID: 24413018
Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count.
RNA (New York, N.Y.) Mar, 2014 | Pubmed ID: 24448447
A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas) in Haloferax volcanii.
The Journal of biological chemistry Mar, 2014 | Pubmed ID: 24459147
In vitro assembly and activity of an archaeal CRISPR-Cas type I-A Cascade interference complex.
Nucleic acids research Apr, 2014 | Pubmed ID: 24500198
The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.
Genes & development Apr, 2014 | Pubmed ID: 24696456
Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D.
Development (Cambridge, England) May, 2014 | Pubmed ID: 24718986
Separation methodology to improve proteome coverage depth.
Expert review of proteomics Aug, 2014 | Pubmed ID: 24834482
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Science (New York, N.Y.) May, 2014 | Pubmed ID: 24876496
Biophysical and biochemical analysis of hnRNP K: arginine methylation, reversible aggregation and combinatorial binding to nucleic acids.
Biological chemistry Jul, 2014 | Pubmed ID: 25003387
Analyzing the protein assembly and dynamics of the human spliceosome with SILAC.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 25059615
Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.
RNA biology Aug, 2014 | Pubmed ID: 25117179
Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins.
Nature methods Oct, 2014 | Pubmed ID: 25173706
Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.
Cellular signalling Jan, 2015 | Pubmed ID: 25452106
RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus.
Molecular cell Nov, 2014 | Pubmed ID: 25457165
Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.
RNA biology Aug, 2014 | Pubmed ID: 25483036
Dual tagging as an approach to isolate endogenous chromatin remodeling complexes from Saccharomyces cerevisiae.
Biochimica et biophysica acta Mar, 2015 | Pubmed ID: 25486077
Effects of mycophenolate mofetil on kidney function and phosphorylation status of renal proteins in Alport COL4A3-deficient mice.
Proteome science , 2014 | Pubmed ID: 25525413
Studying macromolecular complex stoichiometries by peptide-based mass spectrometry.
Proteomics Dec, 2014 | Pubmed ID: 25546807
The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.
Nature structural & molecular biology Feb, 2015 | Pubmed ID: 25599396
FLT3-ITD and TLR9 employ Bruton's tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation.
Blood Jan, 2015 | Pubmed ID: 25605370
Hanibal Bohnenberger1,
Philipp Ströbel1,
Sebastian Mohr2,
Jasmin Corso3,
Tobias Berg2,
Henning Urlaub3,4,
Christof Lenz3,4,
Hubert Serve2,5,6,
Thomas Oellerich2,5,6
1Institute of Pathology, University Medical Center, Göttingen,
2Department of Hematology/Oncology, Goethe University of Frankfurt,
3Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry,
4Bioanalytics, Institute of Clinical Chemistry, University Medical Center, Göttingen,
5, German Cancer Consortium,
6, German Cancer Research Center
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