Division of Regenerative Medicine,
Center for Molecular Medicine,
Division of Stem Cell Research and Drug Development,
Center for Development of Advanced Medical Technology
Hideki Uosaki is an Associate Professor in Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University in Shimotsuke, Japan. HE received his M.D. from Hokkaido University, and a Ph.D from Kyoto University, Japan.
As a post-doctoral fellow (2011-2016) in Chulan Kwon's lab at the Division of Cardiology, Johns Hopkins University School of Medicine, he studied heart development using mouse Cre/Loxp models. He also started to study molecular mechanisms of cardiomyocyte maturation.
Dr. Uosaki moved to Japan in 2016 as a Lecturer of Jichi Medical University and promoted to an Associate Professor in 2017. His research team encompasses using mice, pigs, as well as mouse and human stem cells to decipher the molecular mechanisms of cardiomyocyte maturation and to transform the knowledge and technologies in developmental biology and stem cell biology to ways to support physicians.
The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2.
Cardiovascular research Sep, 2009 | Pubmed ID: 19477969
Production and rearing of germ-free X-SCID pigs.
Experimental animals May, 2018 | Pubmed ID: 29162766
Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.
Cell stem cell 09, 2018 | Pubmed ID: 30100166
Rapid and high-efficient generation of mutant mice using freeze-thawed embryos of the C57BL/6J strain.
Journal of neuroscience methods Apr, 2019 | Pubmed ID: 30684509
Generation of novel Il2rg-knockout mice with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and Cas9.
Experimental animals Dec, 2019 | Pubmed ID: 31801915
A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation.
Scientific reports Mar, 2020 | Pubmed ID: 32144297
A Brief Review of Current Maturation Methods for Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 32266260
Comparative Transcriptome Landscape of Mouse and Human Hearts.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 32391358
Fetal sheep support the development of hematopoietic cells in vivo from human induced pluripotent stem cells.
Experimental hematology Jan, 2021 | Pubmed ID: 33395577
Non-viral genome-editing in mouse bona fide hematopoietic stem cells with CRISPR/Cas9.
Molecular therapy. Methods & clinical development Mar, 2021 | Pubmed ID: 33614821
Hirofumi Nishizono*,1,2,3,
Mohamed Darwish*,4,5,
Hideki Uosaki6,7,
Nanami Masuyama8,9,10,
Motoaki Seki8,11,
Hiroyuki Abe3,
Nozomu Yachie8,9,10,12,13,
Ryohei Yasuda1
1, Max Planck Florida Institute for Neuroscience,
2Life Science Research Center, University of Toyama,
3Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University,
4Graduate School of Innovative Life Science, University of Toyama,
5Department of Biochemistry, Faculty of Pharmacy, Cairo University,
6Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University,
7Division of Stem Cell Research and Drug Development, Center for Development of Advanced Medical Technology, Jichi Medical University,
8Synthetic Biology Division, Research Center for Advanced Science and Technology, University of Tokyo,
9Institute for Advanced Biosciences, Keio University,
10Graduate School of Media and Governance, Keio University,
11Department of Molecular Oncology, Graduate School of Medicine, Chiba University,
12Department of Biological Sciences, School of Science, University of Tokyo,
13College of Arts and Sciences, University of Tokyo
Razan E. Ahmed*,1,
Nawin Chanthra*,1,
Tatsuya Anzai1,2,
Keiichiro Koiwai3,4,
Tomoki Murakami4,
Hiroaki Suzuki4,
Yutaka Hanazono1,
Hideki Uosaki1
1Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University,
2Department of Pediatrics, Jichi Medical University,
3Institute of Global Innovation Research, Tokyo University of Agriculture and Technology,
4Department of Precision Mechanics, Faculty of Science and Engineering, Chuo University
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