Institute for Organic Chemistry and Chemical Biology,
Center for Biomolecular Magnetic Resonance (BMRZ),
Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ)
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Disentangling the coil: modulation of conformational and dynamic properties by site-directed mutation in the non-native state of hen egg white lysozyme.
Biochemistry Apr, 2012 | Pubmed ID: 22468860
Mechanisms for differentiation between cognate and near-cognate ligands by purine riboswitches.
RNA biology May, 2012 | Pubmed ID: 22647526
Kurt Wüthrich, the ETH Zürich, and the development of NMR spectroscopy for the investigation of structure, dynamics, and folding of proteins.
Chembiochem : a European journal of chemical biology Mar, 2003 | Pubmed ID: 12616625
1H, 13C and 15N backbone resonance assignment of the integrin alpha2 I-domain.
Journal of biomolecular NMR Oct, 2003 | Pubmed ID: 12913420
NMR spectroscopy of RNA.
Chembiochem : a European journal of chemical biology Oct, 2003 | Pubmed ID: 14523911
New NMR experiments for RNA nucleobase resonance assignment and chemical shift analysis of an RNA UUCG tetraloop.
Journal of biomolecular NMR Jan, 2004 | Pubmed ID: 14739640
Determination of the glycosidic bond angle chi in RNA from cross-correlated relaxation of CH dipolar coupling and N chemical shift anisotropy.
Journal of the American Chemical Society Feb, 2004 | Pubmed ID: 14971929
Modulation of compactness and long-range interactions of unfolded lysozyme by single point mutations.
Angewandte Chemie (International ed. in English) Nov, 2004 | Pubmed ID: 15523735
Folding and activity of cAMP-dependent protein kinase mutants.
FEBS letters Aug, 2005 | Pubmed ID: 16026785
Characterisation of disulfide-bond dynamics in non-native states of lysozyme and its disulfide deletion mutants by NMR.
Chembiochem : a European journal of chemical biology Sep, 2005 | Pubmed ID: 16138305
Structure and dynamics of an RNA tetraloop: a joint molecular dynamics and NMR study.
Structure (London, England : 1993) Sep, 2005 | Pubmed ID: 16154083
Residue specific ribose and nucleobase dynamics of the cUUCGg RNA tetraloop motif by MNMR 13C relaxation.
Journal of biomolecular NMR Aug, 2005 | Pubmed ID: 16211483
Heterologous expression of hen egg white lysozyme and resonance assignment of tryptophan side chains in its non-native states.
Journal of biomolecular NMR Oct, 2005 | Pubmed ID: 16258828
NMR characterization of kinase p38 dynamics in free and ligand-bound forms.
Angewandte Chemie (International ed. in English) Jan, 2006 | Pubmed ID: 16374788
Photo-CIDNP reveals differences in compaction of non-native states of lysozyme.
Journal of the American Chemical Society Feb, 2006 | Pubmed ID: 16464074
Biomolecular NMR: a chaperone to drug discovery.
Current opinion in chemical biology Jun, 2006 | Pubmed ID: 16679046
Characterization of the unfolded state of bovine alpha-lactalbumin and comparison with unfolded states of homologous proteins.
Protein science : a publication of the Protein Society Jun, 2006 | Pubmed ID: 16731974
Motional properties of unfolded ubiquitin: a model for a random coil protein.
Journal of biomolecular NMR Jul, 2006 | Pubmed ID: 16865418
Phosphate-group recognition by the aptamer domain of the thiamine pyrophosphate sensing riboswitch.
Chembiochem : a European journal of chemical biology Sep, 2006 | Pubmed ID: 16871614
L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy.
Nucleic acids research , 2007 | Pubmed ID: 17169991
Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch.
Nucleic acids research , 2007 | Pubmed ID: 17175531
Structures of RNA switches: insight into molecular recognition and tertiary structure.
Angewandte Chemie (International ed. in English) , 2007 | Pubmed ID: 17226886
Structure and dynamics of the homologous series of alanine peptides: a joint molecular dynamics/NMR study.
Journal of the American Chemical Society Feb, 2007 | Pubmed ID: 17263399
Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy.
Chembiochem : a European journal of chemical biology May, 2007 | Pubmed ID: 17410622
Time-resolved NMR studies of RNA folding.
Biopolymers Aug 5-15, 2007 | Pubmed ID: 17595685
Quantitative gamma-HCNCH: determination of the glycosidic torsion angle chi in RNA oligonucleotides from the analysis of CH dipolar cross-correlated relaxation by solution NMR spectroscopy.
Journal of biomolecular NMR Sep, 2007 | Pubmed ID: 17641824
Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain.
Nucleic acids research , 2007 | Pubmed ID: 17686787
Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2007 | Pubmed ID: 17895388
Isotope labeling of mammalian GPCRs in HEK293 cells and characterization of the C-terminus of bovine rhodopsin by high resolution liquid NMR spectroscopy.
Journal of biomolecular NMR Jan, 2008 | Pubmed ID: 17999150
Conformational dynamics of bistable RNAs studied by time-resolved NMR spectroscopy.
Journal of the American Chemical Society Dec, 2007 | Pubmed ID: 18047344
The structure of the neuropeptide bradykinin bound to the human G-protein coupled receptor bradykinin B2 as determined by solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English) , 2008 | Pubmed ID: 18236494
Conserved folding pathways of alpha-lactalbumin and lysozyme revealed by kinetic CD, fluorescence, NMR, and interrupted refolding experiments.
Journal of molecular biology May, 2008 | Pubmed ID: 18377934
NMR-spectroscopic characterization of phosphodiester bond cleavage catalyzed by the minimal hammerhead ribozyme.
RNA biology Jan-Mar, 2008 | Pubmed ID: 18388486
The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158.
Chembiochem : a European journal of chemical biology Jan, 2009 | Pubmed ID: 19067455
The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy.
The Journal of biological chemistry Feb, 2009 | Pubmed ID: 19073599
The correlation of cathodic peak potentials of vitamin K(3) derivatives and their calculated electron affinities. The role of hydrogen bonding and conformational changes.
Biochimica et biophysica acta Jun, 2009 | Pubmed ID: 19265668
Metal-induced folding of Diels-Alderase ribozymes studied by static and time-resolved NMR spectroscopy.
Journal of the American Chemical Society May, 2009 | Pubmed ID: 19354210
Time-resolved NMR spectroscopy: ligand-induced refolding of riboswitches.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19381559
HNHC: a triple resonance experiment for correlating the H2, N1(N3) and C2 resonances in adenine nucleobases of 13C-, 15N-labeled RNA oligonucleotides.
Journal of biomolecular NMR Jun, 2009 | Pubmed ID: 19424666
Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.
Angewandte Chemie (International ed. in English) , 2009 | Pubmed ID: 19585625
NMR spectroscopic characterization of the adenine-dependent hairpin ribozyme.
Chembiochem : a European journal of chemical biology Aug, 2009 | Pubmed ID: 19623596
RNA phosphodiester backbone dynamics of a perdeuterated cUUCGg tetraloop RNA from phosphorus-31 NMR relaxation analysis.
Journal of biomolecular NMR Sep, 2009 | Pubmed ID: 19636800
High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA.
Nucleic acids research Jan, 2010 | Pubmed ID: 19906714
The HN(COCA)HAHB NMR experiment for the stereospecific assignment of Hbeta-protons in non-native states of proteins.
Journal of the American Chemical Society Jan, 2010 | Pubmed ID: 20039672
Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain.
Nucleic acids research Jul, 2010 | Pubmed ID: 20200045
Direct observation of the temperature-induced melting process of the Salmonella fourU RNA thermometer at base-pair resolution.
Nucleic acids research Jun, 2010 | Pubmed ID: 20211842
Prion protein amyloid formation involves structural rearrangements in the C-terminal domain.
Chembiochem : a European journal of chemical biology Jun, 2010 | Pubmed ID: 20458726
Probing mechanism and transition state of RNA refolding.
ACS chemical biology Aug, 2010 | Pubmed ID: 20536261
13C-direct detected NMR experiments for the sequential J-based resonance assignment of RNA oligonucleotides.
Journal of biomolecular NMR Aug, 2010 | Pubmed ID: 20544375
Influence of heparin mimetics on assembly of the FGF.FGFR4 signaling complex.
The Journal of biological chemistry Aug, 2010 | Pubmed ID: 20547770
The molecular mechanism of spider-silk formation.
Angewandte Chemie (International ed. in English) Jul, 2010 | Pubmed ID: 20586091
Quantitative 2D and 3D Gamma-HCP experiments for the determination of the angles alpha and zeta in the phosphodiester backbone of oligonucleotides.
Journal of the American Chemical Society Aug, 2010 | Pubmed ID: 20614918
Folding kinetics for the conformational switch between alternative RNA structures.
The journal of physical chemistry. B Oct, 2010 | Pubmed ID: 20886868
Translation on demand by a simple RNA-based thermosensor.
Nucleic acids research Apr, 2011 | Pubmed ID: 21131278
Engineering encodable lanthanide-binding tags into loop regions of proteins.
Journal of the American Chemical Society Feb, 2011 | Pubmed ID: 21182275
Double take on Piwi protein/piRNA complex structure.
Structure (London, England : 1993) Feb, 2011 | Pubmed ID: 21300281
Characteristics of human lysozyme and its disease-related mutants in their unfolded states.
Angewandte Chemie (International ed. in English) Jun, 2011 | Pubmed ID: 21574221
Structure and dynamics of the deoxyguanosine-sensing riboswitch studied by NMR-spectroscopy.
Nucleic acids research Aug, 2011 | Pubmed ID: 21576236
Modulation of the stability of the Salmonella fourU-type RNA thermometer.
Nucleic acids research Oct, 2011 | Pubmed ID: 21727085
Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain.
Nucleic acids research Dec, 2011 | Pubmed ID: 21890900
Mapping the landscape of RNA dynamics with NMR spectroscopy.
Accounts of chemical research Dec, 2011 | Pubmed ID: 21894962
NMR spectroscopic investigations of the activated p38α mitogen-activated protein kinase.
Chembiochem : a European journal of chemical biology Nov, 2011 | Pubmed ID: 22012687
Solution NMR structure of proteorhodopsin.
Angewandte Chemie (International ed. in English) Dec, 2011 | Pubmed ID: 22034093
Time-resolved NMR spectroscopic studies of DNA i-motif folding reveal kinetic partitioning.
Angewandte Chemie (International ed. in English) Jan, 2012 | Pubmed ID: 22095623
Isotope labeling in insect cells.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22167667
Isotope labeling in mammalian cells.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22167668
Functional dynamics of RNA ribozymes studied by NMR spectroscopy.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22315070
Blind testing of routine, fully automated determination of protein structures from NMR data.
Structure (London, England : 1993) Feb, 2012 | Pubmed ID: 22325772
Modulation of structure and dynamics by disulfide bond formation in unfolded states.
Journal of the American Chemical Society Apr, 2012 | Pubmed ID: 22414027
Individual basepair stability of DNA and RNA studied by NMR-detected solvent exchange.
Biophysical journal Jun, 2012 | Pubmed ID: 22713572
¹H, ¹³C and ¹⁵N assignment of D2 domain of human fibroblast growth factor receptor 4.
Biomolecular NMR assignments Oct, 2013 | Pubmed ID: 22752790
Recombinant expression and purification of human TATA binding protein using a chimeric fusion.
Protein expression and purification Sep, 2012 | Pubmed ID: 22841618
Atomic-level structure characterization of an ultrafast folding mini-protein denatured state.
PloS one , 2012 | Pubmed ID: 22848459
The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22888002
NMR studies of HAR1 RNA secondary structures reveal conformational dynamics in the human RNA.
Chembiochem : a European journal of chemical biology Sep, 2012 | Pubmed ID: 22961937
Characterization of the ground state dynamics of proteorhodopsin by NMR and optical spectroscopies.
Journal of biomolecular NMR Dec, 2012 | Pubmed ID: 23160927
Disorder and order in unfolded and disordered peptides and proteins: a view derived from tripeptide conformational analysis. II. Tripeptides with short side chains populating asx and β-type like turn conformations.
Proteins Jun, 2013 | Pubmed ID: 23229867
Optimizing the kinetics and thermodynamics of DNA i-motif folding.
Chembiochem : a European journal of chemical biology Jul, 2013 | Pubmed ID: 23794335
Kinase in motion: insights into the dynamic nature of p38α by high-pressure NMR spectroscopic studies.
Chembiochem : a European journal of chemical biology Sep, 2013 | Pubmed ID: 23843149
MOTOR: model assisted software for NMR structure determination.
Proteins Nov, 2013 | Pubmed ID: 23852655
Detecting intracellular cysteine redox states by in-cell NMR spectroscopy.
Chembiochem : a European journal of chemical biology Sep, 2013 | Pubmed ID: 23893841
RNA refolding studied by light-coupled NMR spectroscopy.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24136612
Design, synthesis, and biological testing of novel naphthoquinones as substrate-based inhibitors of the quinol/fumarate reductase from Wolinella succinogenes.
Journal of medicinal chemistry Dec, 2013 | Pubmed ID: 24251984
Influence of the absolute configuration of npe-caged cytosine on DNA single base pair stability.
Angewandte Chemie (International ed. in English) Jan, 2014 | Pubmed ID: 24339185
Characterization of the simultaneous decay kinetics of metarhodopsin states II and III in rhodopsin by solution-state NMR spectroscopy.
Angewandte Chemie (International ed. in English) Feb, 2014 | Pubmed ID: 24505031
Mechanism of the photoinduced uncaging reaction of puromycin protected by a 6-nitroveratryloxycarbonyl group.
Journal of the American Chemical Society Mar, 2014 | Pubmed ID: 24517286
Structure determination of noncanonical RNA motifs guided by ¹H NMR chemical shifts.
Nature methods Apr, 2014 | Pubmed ID: 24584194
Noncovalent spin labeling of riboswitch RNAs to obtain long-range structural NMR restraints.
ACS chemical biology Jun, 2014 | Pubmed ID: 24673892
The cytochrome c peroxidase and cytochrome c encounter complex: the other side of the story.
FEBS letters May, 2014 | Pubmed ID: 24726731
Protocol for aerosol-free recombinant production and NMR analysis of prion proteins.
Journal of biomolecular NMR Jun, 2014 | Pubmed ID: 24771297
The importance of helix P1 stability for structural pre-organization and ligand binding affinity of the adenine riboswitch aptamer domain.
RNA biology , 2014 | Pubmed ID: 24921630
Integrated protocol for reliable and fast quantification and documentation of electrophoresis gels.
Protein expression and purification Jun, 2015 | Pubmed ID: 25514201
A temperature-jump NMR probe setup using rf heating optimized for the analysis of temperature-induced biomacromolecular kinetic processes.
Journal of magnetic resonance (San Diego, Calif. : 1997) Feb, 2015 | Pubmed ID: 25616187
Characterization of conformational dynamics of bistable RNA by equilibrium and non-equilibrium NMR.
Current protocols in nucleic acid chemistry Dec, 2014 | Pubmed ID: 25631532
Differential scanning fluorimetry for monitoring RNA stability.
Chembiochem : a European journal of chemical biology May, 2015 | Pubmed ID: 25867500
Mechanistic insights into temperature-dependent regulation of the simple cyanobacterial hsp17 RNA thermometer at base-pair resolution.
Nucleic acids research Jun, 2015 | Pubmed ID: 25940621
Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina.
The Journal of biological chemistry Jun, 2015 | Pubmed ID: 25979334
Tuning the pH Response of i-Motif DNA Oligonucleotides.
Chembiochem : a European journal of chemical biology Jul, 2015 | Pubmed ID: 26032298
Involvement of Long-Lived Intermediate States in the Complex Folding Pathway of the Human Telomeric G-Quadruplex.
Angewandte Chemie (International ed. in English) Jul, 2015 | Pubmed ID: 26036989
Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy.
Angewandte Chemie (International ed. in English) Aug, 2015 | Pubmed ID: 26136394
Enlightening the photoactive site of channelrhodopsin-2 by DNP-enhanced solid-state NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2015 | Pubmed ID: 26216996
High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.
Acta crystallographica. Section F, Structural biology communications Aug, 2015 | Pubmed ID: 26249705
Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells.
ACS chemical biology Nov, 2015 | Pubmed ID: 26279064
A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer Cells.
Scientific reports Aug, 2015 | Pubmed ID: 26286633
Encoded loop-lanthanide-binding tags for long-range distance measurements in proteins by NMR and EPR spectroscopy.
Journal of biomolecular NMR Nov, 2015 | Pubmed ID: 26341230
Influence of Arrestin on the Photodecay of Bovine Rhodopsin.
Angewandte Chemie (International ed. in English) Nov, 2015 | Pubmed ID: 26383645
(19)F-labeling of the adenine H2-site to study large RNAs by NMR spectroscopy.
Journal of biomolecular NMR Jan, 2016 | Pubmed ID: 26704707
Fluorescent Dansyl-Guanosine Conjugates that Bind c-MYC Promoter G-Quadruplex and Downregulate c-MYC Expression.
Chembiochem : a European journal of chemical biology Mar, 2016 | Pubmed ID: 26708259
Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.
Angewandte Chemie (International ed. in English) Feb, 2016 | Pubmed ID: 26805928
Corrigendum to "The cytochrome c peroxidase and cytochrome c encounter complex: The other side of the story" [FEBS Lett. 588 (2014) 1873-1878].
FEBS letters Jul, 2015 | Pubmed ID: 26845621
Direct ¹³C-detected NMR experiments for mapping and characterization of hydrogen bonds in RNA.
Journal of biomolecular NMR Mar, 2016 | Pubmed ID: 26852414
Understanding How DNA Enzymes Work.
Angewandte Chemie (International ed. in English) 04, 2016 | Pubmed ID: 26990154
Reduced and mutant lysozyme refolding with lipid vesicles. Model study of disulfide impact on equilibria and dynamics.
Biochimica et biophysica acta 09, 2016 | Pubmed ID: 27240304
Synthesis of Fluorescent Binaphthyl Amines That Bind c-MYC G-Quadruplex DNA and Repress c-MYC Expression.
Journal of medicinal chemistry Aug, 2016 | Pubmed ID: 27442915
Gd(iii) and Mn(ii) complexes for dynamic nuclear polarization: small molecular chelate polarizing agents and applications with site-directed spin labeling of proteins.
Physical chemistry chemical physics : PCCP Oct, 2016 | Pubmed ID: 27545112
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Nature medicine 10, 2016 | Pubmed ID: 27595325
Terphenyl Derivatives from Allantophomopsis lycopodina.
Journal of natural products 10, 2016 | Pubmed ID: 27731998
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS chemical biology 12, 2016 | Pubmed ID: 27768280
The Absence of the N-acyl-homoserine-lactone Autoinducer Synthase Genes and Increases the Copy Number of the Symbiotic Plasmid in NGR234.
Frontiers in microbiology , 2016 | Pubmed ID: 27917168
Heteronuclear Cross-Relaxation under Solid-State Dynamic Nuclear Polarization.
Journal of the American Chemical Society 12, 2016 | Pubmed ID: 27934234
Ligand binding to 2΄-deoxyguanosine sensing riboswitch in metabolic context.
Nucleic acids research May, 2017 | Pubmed ID: 28115631
Impact of spin label rigidity on extent and accuracy of distance information from PRE data.
Journal of biomolecular NMR May, 2017 | Pubmed ID: 28500543
Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.
Angewandte Chemie (International ed. in English) 06, 2017 | Pubmed ID: 28524432
Conformational dynamics and alignment properties of loop lanthanide-binding-tags (LBTs) studied in interleukin-1β.
Journal of biomolecular NMR Jul, 2017 | Pubmed ID: 28534082
Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation.
eLife 05, 2017 | Pubmed ID: 28541183
Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem 06, 2017 | Pubmed ID: 28544567
Mistakes in translation: Reflections on mechanism.
PloS one , 2017 | Pubmed ID: 28662217
Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.
Chembiochem : a European journal of chemical biology 10, 2017 | Pubmed ID: 28805284
Evaluation of N-detected H-N correlation experiments on increasingly large RNAs.
Journal of biomolecular NMR Sep, 2017 | Pubmed ID: 28879611
Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding.
Chembiochem : a European journal of chemical biology 12, 2017 | Pubmed ID: 28950050
The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nature chemical biology 03, 2018 | Pubmed ID: 29334381
Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.
FEBS letters 04, 2018 | Pubmed ID: 29494752
Life times of metastable states guide regulatory signaling in transcriptional riboswitches.
Nature communications 03, 2018 | Pubmed ID: 29507289
Improved high-yield expression, purification and refolding of recombinant mammalian prion proteins under aerosol-free elevated biological safety conditions.
Protein expression and purification 10, 2018 | Pubmed ID: 29751084
Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex.
Nucleic acids research 06, 2018 | Pubmed ID: 29762718
Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.
Nature communications 05, 2018 | Pubmed ID: 29795225
The domain architecture of PtkA, the first tyrosine kinase from , differs from the conventional kinase architecture.
The Journal of biological chemistry 07, 2018 | Pubmed ID: 29884774
Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds.
ACS chemical biology 08, 2018 | Pubmed ID: 29927572
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
ChemMedChem 08, 2018 | Pubmed ID: 29928781
Small molecule regulated dynamic structural changes of human G-quadruplexes.
Chemical science May, 2016 | Pubmed ID: 29997820
Chemo-Enzymatic Synthesis of Position-Specifically Modified RNA for Biophysical Studies including Light Control and NMR Spectroscopy.
Angewandte Chemie (International ed. in English) 09, 2018 | Pubmed ID: 30007102
Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging.
Chemistry (Weinheim an der Bergstrasse, Germany) Nov, 2018 | Pubmed ID: 30199112
A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons.
Chembiochem : a European journal of chemical biology 12, 2018 | Pubmed ID: 30311996
Combined smFRET and NMR analysis of riboswitch structural dynamics.
Methods (San Diego, Calif.) 01, 2019 | Pubmed ID: 30316819
Identification of primary and secondary metabolites and transcriptome profile of soybean tissues during different stages of hypoxia.
Data in brief Dec, 2018 | Pubmed ID: 30450404
"CodonWizard" - An intuitive software tool with graphical user interface for customizable codon optimization in protein expression efforts.
Protein expression and purification 08, 2019 | Pubmed ID: 30953700
Solution Structure and Dynamics of the Small Protein HVO_2922 from Haloferax volcanii.
Chembiochem : a European journal of chemical biology 01, 2020 | Pubmed ID: 31161645
Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma.
Molecular oncology 11, 2019 | Pubmed ID: 31545551
Paramagnetic-iterative relaxation matrix approach: extracting PRE-restraints from NOESY spectra for 3D structure elucidation of biomolecules.
Journal of biomolecular NMR Dec, 2019 | Pubmed ID: 31606877
G-Quadruplex-Specific Cell-Permeable Guanosine-Anthracene Conjugate Inhibits Telomere Elongation and Induces Apoptosis by Repressing the Gene.
Bioconjugate chemistry 12, 2019 | Pubmed ID: 31663728
Genetic Code Expansion Facilitates Position-Selective Labeling of RNA for Biophysical Studies.
Chemistry (Weinheim an der Bergstrasse, Germany) Feb, 2020 | Pubmed ID: 31692134
Rapid Biophysical Characterization and NMR Spectroscopy Structural Analysis of Small Proteins from Bacteria and Archaea.
Chembiochem : a European journal of chemical biology 04, 2020 | Pubmed ID: 31705614
Real-Time NMR Spectroscopy for Studying Metabolism.
Angewandte Chemie (International ed. in English) 02, 2020 | Pubmed ID: 31730253
Conformational Dynamics of Strand Register Shifts in DNA G-Quadruplexes.
Journal of the American Chemical Society 01, 2020 | Pubmed ID: 31815451
Structure Validation of G-Rich RNAs in Noncoding Regions of the Human Genome.
Chembiochem : a European journal of chemical biology 06, 2020 | Pubmed ID: 31943589
A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR.
Proceedings of the National Academy of Sciences of the United States of America 02, 2020 | Pubmed ID: 31949004
Refolding through a Linear Transition State Enables Fast Temperature Adaptation of a Translational Riboswitch.
Biochemistry 03, 2020 | Pubmed ID: 32134253
Site-Specific Detection of Arginine Methylation in Highly Repetitive Protein Motifs of Low Sequence Complexity by NMR.
Journal of the American Chemical Society 04, 2020 | Pubmed ID: 32233470
The conformational landscape of transcription intermediates involved in the regulation of the ZMP-sensing riboswitch from Thermosinus carboxydivorans.
Nucleic acids research 07, 2020 | Pubmed ID: 32479610
Structural basis for the recognition of transiently structured AU-rich elements by Roquin.
Nucleic acids research 07, 2020 | Pubmed ID: 32491174
Genetic Code Expansion Facilitates Position-Selective Modification of Nucleic Acids and Proteins.
ChemPlusChem 06, 2020 | Pubmed ID: 32515171
NMR quality control of fragment libraries for screening.
Journal of biomolecular NMR Nov, 2020 | Pubmed ID: 32533387
Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant.
Angewandte Chemie (International ed. in English) 09, 2020 | Pubmed ID: 32602600
Anti-tyrosinase, anti-cholinesterase and cytotoxic activities of extracts and phytochemicals from the Tunisian Citharexylum spinosum L.: Molecular docking and SAR analysis.
Bioorganic chemistry 09, 2020 | Pubmed ID: 32717693
NMR Spectroscopic Characterization of the C-Mannose Conformation in a Thrombospondin Repeat Using a Selective Labeling Approach.
Angewandte Chemie (International ed. in English) 11, 2020 | Pubmed ID: 32745319
H, C, and N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3e.
Biomolecular NMR assignments 10, 2020 | Pubmed ID: 32770392
Quantitative modeling of the function of kinetically driven transcriptional riboswitches.
Journal of theoretical biology 12, 2020 | Pubmed ID: 32771533
F NMR-Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter-Screens.
Chembiochem : a European journal of chemical biology Jan, 2021 | Pubmed ID: 32794266
H, C, and N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b.
Biomolecular NMR assignments 10, 2020 | Pubmed ID: 32803496
NMR Spectroscopy of Large Functional RNAs: From Sample Preparation to Low-Gamma Detection.
Current protocols in nucleic acid chemistry 09, 2020 | Pubmed ID: 32960489
Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids.
Nature communications 10, 2020 | Pubmed ID: 33087707
Site-specific dynamic nuclear polarization in a Gd(III)-labeled protein.
Physical chemistry chemical physics : PCCP Nov, 2020 | Pubmed ID: 33103678
Cysteine oxidation and disulfide formation in the ribosomal exit tunnel.
Nature communications 11, 2020 | Pubmed ID: 33149120
The Pyrazolo[3,4-]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts.
Molecules (Basel, Switzerland) Nov, 2020 | Pubmed ID: 33153234
H, C, and N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10.
Biomolecular NMR assignments 04, 2021 | Pubmed ID: 33159807
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy.
Nucleic acids research 12, 2020 | Pubmed ID: 33167030
H,C and N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "the N-terminal domain-SUD-N".
Biomolecular NMR assignments 04, 2021 | Pubmed ID: 33225414
Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia.
Cancers Nov, 2020 | Pubmed ID: 33228196
H, C, and N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein.
Biomolecular NMR assignments 04, 2021 | Pubmed ID: 33270159
Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide.
Cell research Jul, 2021 | Pubmed ID: 33318647
H,C and N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "The SUD-M and SUD-C domains".
Biomolecular NMR assignments 04, 2021 | Pubmed ID: 33423172
H, C and N backbone chemical shift assignments of SARS-CoV-2 nsp3a.
Biomolecular NMR assignments 04, 2021 | Pubmed ID: 33475934
H, C and N chemical shift assignment of the stem-loop 5a from the 5'-UTR of SARS-CoV-2.
Biomolecular NMR assignments 04, 2021 | Pubmed ID: 33484403
Synthesis and in Vitro Evaluation of Novel 5-Nitroindole Derivatives as c-Myc G-Quadruplex Binders with Anticancer Activity.
ChemMedChem May, 2021 | Pubmed ID: 33508167
The Folding Landscapes of Human Telomeric RNA and DNA G-Quadruplexes are Markedly Different.
Angewandte Chemie (International ed. in English) 05, 2021 | Pubmed ID: 33539622
High complexity of Glutamine synthetase regulation in Methanosarcina mazei: Small protein 26 interacts and enhances glutamine synthetase activity.
The FEBS journal Mar, 2021 | Pubmed ID: 33660383
Magnetization Transfer to Enhance NOE Cross-Peaks among Labile Protons: Applications to Imino-Imino Sequential Walks in SARS-CoV-2-Derived RNAs.
Angewandte Chemie (International ed. in English) 05, 2021 | Pubmed ID: 33683819
Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9.
Biomolecular NMR assignments Mar, 2021 | Pubmed ID: 33755914
H, C, and N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein).
Biomolecular NMR assignments Mar, 2021 | Pubmed ID: 33770349
3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs.
Journal of the American Chemical Society 04, 2021 | Pubmed ID: 33783202
Unraveling the Kinetics of Spare-Tire DNA G-Quadruplex Folding.
Journal of the American Chemical Society 04, 2021 | Pubmed ID: 33872503
H, C, N and P chemical shift assignment for stem-loop 4 from the 5'-UTR of SARS-CoV-2.
Biomolecular NMR assignments 10, 2021 | Pubmed ID: 33928512
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
Frontiers in molecular biosciences , 2021 | Pubmed ID: 34041264
Insights from Binding on Quadruplex Selective Carbazole Ligands.
Chemistry (Weinheim an der Bergstrasse, Germany) Sep, 2021 | Pubmed ID: 34138492
Correction to 'Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy'.
Nucleic acids research Jul, 2021 | Pubmed ID: 34161581
Wavelength-Selective Uncaging of Two Different Photoresponsive Groups on One Effector Molecule for Light-Controlled Activation and Deactivation.
Journal of the American Chemical Society Jul, 2021 | Pubmed ID: 34236854
Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation.
Nature communications 08, 2021 | Pubmed ID: 34354064
H, C and N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2.
Biomolecular NMR assignments 10, 2021 | Pubmed ID: 34453696
Oxidative Folding of Proteins: The "Smoking Gun" of Glutathione.
International journal of molecular sciences Sep, 2021 | Pubmed ID: 34576311
Folding dynamics of polymorphic G-quadruplex structures.
Biopolymers Oct, 2021 | Pubmed ID: 34664713
Hans Wienk1,
Lucia Banci2,
Susan Daenke3,
Eva Pereiro4,
Harald Schwalbe5,
David Ian Stuart6,
Manfred S. Weiss7,
Anastassis Perrakis1
1Division of Biochemistry and Oncode Institute, The Netherlands Cancer Institute, Amsterdam,
2CERM/CIRMMP, University of Florence,
3Instruct-ERIC, Oxford University,
4MISTRAL beamline, Alba Light Source,
5Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt,
6Division of Structural Biology, Oxford University,
7Macromolecular Crystallographyy, Helmholtz-Zentrum Berlin
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