Harald Schwalbe

Disentangling the coil: modulation of conformational and dynamic properties by site-directed mutation in the non-native state of hen egg white lysozyme.

Mechanisms for differentiation between cognate and near-cognate ligands by purine riboswitches.

Kurt Wüthrich, the ETH Zürich, and the development of NMR spectroscopy for the investigation of structure, dynamics, and folding of proteins.

1H, 13C and 15N backbone resonance assignment of the integrin alpha2 I-domain.

NMR spectroscopy of RNA.

New NMR experiments for RNA nucleobase resonance assignment and chemical shift analysis of an RNA UUCG tetraloop.

Determination of the glycosidic bond angle chi in RNA from cross-correlated relaxation of CH dipolar coupling and N chemical shift anisotropy.

Modulation of compactness and long-range interactions of unfolded lysozyme by single point mutations.

Folding and activity of cAMP-dependent protein kinase mutants.

Characterisation of disulfide-bond dynamics in non-native states of lysozyme and its disulfide deletion mutants by NMR.

Structure and dynamics of an RNA tetraloop: a joint molecular dynamics and NMR study.

Residue specific ribose and nucleobase dynamics of the cUUCGg RNA tetraloop motif by MNMR 13C relaxation.

Heterologous expression of hen egg white lysozyme and resonance assignment of tryptophan side chains in its non-native states.

NMR characterization of kinase p38 dynamics in free and ligand-bound forms.

Photo-CIDNP reveals differences in compaction of non-native states of lysozyme.

Biomolecular NMR: a chaperone to drug discovery.

Characterization of the unfolded state of bovine alpha-lactalbumin and comparison with unfolded states of homologous proteins.

Motional properties of unfolded ubiquitin: a model for a random coil protein.

Phosphate-group recognition by the aptamer domain of the thiamine pyrophosphate sensing riboswitch.

L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy.

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch.

Structures of RNA switches: insight into molecular recognition and tertiary structure.

Structure and dynamics of the homologous series of alanine peptides: a joint molecular dynamics/NMR study.

Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy.

Time-resolved NMR studies of RNA folding.

Quantitative gamma-HCNCH: determination of the glycosidic torsion angle chi in RNA oligonucleotides from the analysis of CH dipolar cross-correlated relaxation by solution NMR spectroscopy.

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain.

Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution.

Isotope labeling of mammalian GPCRs in HEK293 cells and characterization of the C-terminus of bovine rhodopsin by high resolution liquid NMR spectroscopy.

Conformational dynamics of bistable RNAs studied by time-resolved NMR spectroscopy.

The structure of the neuropeptide bradykinin bound to the human G-protein coupled receptor bradykinin B2 as determined by solid-state NMR spectroscopy.

Conserved folding pathways of alpha-lactalbumin and lysozyme revealed by kinetic CD, fluorescence, NMR, and interrupted refolding experiments.

NMR-spectroscopic characterization of phosphodiester bond cleavage catalyzed by the minimal hammerhead ribozyme.

The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158.

The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy.

The correlation of cathodic peak potentials of vitamin K(3) derivatives and their calculated electron affinities. The role of hydrogen bonding and conformational changes.

Metal-induced folding of Diels-Alderase ribozymes studied by static and time-resolved NMR spectroscopy.

Time-resolved NMR spectroscopy: ligand-induced refolding of riboswitches.

HNHC: a triple resonance experiment for correlating the H2, N1(N3) and C2 resonances in adenine nucleobases of 13C-, 15N-labeled RNA oligonucleotides.

Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.

NMR spectroscopic characterization of the adenine-dependent hairpin ribozyme.

RNA phosphodiester backbone dynamics of a perdeuterated cUUCGg tetraloop RNA from phosphorus-31 NMR relaxation analysis.

High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA.

The HN(COCA)HAHB NMR experiment for the stereospecific assignment of Hbeta-protons in non-native states of proteins.

Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain.

Direct observation of the temperature-induced melting process of the Salmonella fourU RNA thermometer at base-pair resolution.

Prion protein amyloid formation involves structural rearrangements in the C-terminal domain.

Probing mechanism and transition state of RNA refolding.

13C-direct detected NMR experiments for the sequential J-based resonance assignment of RNA oligonucleotides.

Influence of heparin mimetics on assembly of the FGF.FGFR4 signaling complex.

The molecular mechanism of spider-silk formation.

Quantitative 2D and 3D Gamma-HCP experiments for the determination of the angles alpha and zeta in the phosphodiester backbone of oligonucleotides.

Folding kinetics for the conformational switch between alternative RNA structures.

Translation on demand by a simple RNA-based thermosensor.

Engineering encodable lanthanide-binding tags into loop regions of proteins.

Double take on Piwi protein/piRNA complex structure.

Characteristics of human lysozyme and its disease-related mutants in their unfolded states.

Structure and dynamics of the deoxyguanosine-sensing riboswitch studied by NMR-spectroscopy.

Modulation of the stability of the Salmonella fourU-type RNA thermometer.

Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain.

Mapping the landscape of RNA dynamics with NMR spectroscopy.

NMR spectroscopic investigations of the activated p38α mitogen-activated protein kinase.

Solution NMR structure of proteorhodopsin.

Time-resolved NMR spectroscopic studies of DNA i-motif folding reveal kinetic partitioning.

Isotope labeling in insect cells.

Isotope labeling in mammalian cells.

Functional dynamics of RNA ribozymes studied by NMR spectroscopy.

Blind testing of routine, fully automated determination of protein structures from NMR data.

Modulation of structure and dynamics by disulfide bond formation in unfolded states.

Individual basepair stability of DNA and RNA studied by NMR-detected solvent exchange.

¹H, ¹³C and ¹⁵N assignment of D2 domain of human fibroblast growth factor receptor 4.

Recombinant expression and purification of human TATA binding protein using a chimeric fusion.

Atomic-level structure characterization of an ultrafast folding mini-protein denatured state.

The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.

NMR studies of HAR1 RNA secondary structures reveal conformational dynamics in the human RNA.

Characterization of the ground state dynamics of proteorhodopsin by NMR and optical spectroscopies.

Disorder and order in unfolded and disordered peptides and proteins: a view derived from tripeptide conformational analysis. II. Tripeptides with short side chains populating asx and β-type like turn conformations.

Optimizing the kinetics and thermodynamics of DNA i-motif folding.

Kinase in motion: insights into the dynamic nature of p38α by high-pressure NMR spectroscopic studies.

MOTOR: model assisted software for NMR structure determination.

Detecting intracellular cysteine redox states by in-cell NMR spectroscopy.

RNA refolding studied by light-coupled NMR spectroscopy.

Design, synthesis, and biological testing of novel naphthoquinones as substrate-based inhibitors of the quinol/fumarate reductase from Wolinella succinogenes.

Influence of the absolute configuration of npe-caged cytosine on DNA single base pair stability.

Characterization of the simultaneous decay kinetics of metarhodopsin states II and III in rhodopsin by solution-state NMR spectroscopy.

Mechanism of the photoinduced uncaging reaction of puromycin protected by a 6-nitroveratryloxycarbonyl group.

Structure determination of noncanonical RNA motifs guided by ¹H NMR chemical shifts.

Noncovalent spin labeling of riboswitch RNAs to obtain long-range structural NMR restraints.

The cytochrome c peroxidase and cytochrome c encounter complex: the other side of the story.

Protocol for aerosol-free recombinant production and NMR analysis of prion proteins.

The importance of helix P1 stability for structural pre-organization and ligand binding affinity of the adenine riboswitch aptamer domain.

Integrated protocol for reliable and fast quantification and documentation of electrophoresis gels.

A temperature-jump NMR probe setup using rf heating optimized for the analysis of temperature-induced biomacromolecular kinetic processes.

Characterization of conformational dynamics of bistable RNA by equilibrium and non-equilibrium NMR.

Differential scanning fluorimetry for monitoring RNA stability.

Mechanistic insights into temperature-dependent regulation of the simple cyanobacterial hsp17 RNA thermometer at base-pair resolution.

Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina.

Tuning the pH Response of i-Motif DNA Oligonucleotides.

Involvement of Long-Lived Intermediate States in the Complex Folding Pathway of the Human Telomeric G-Quadruplex.

Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy.

Enlightening the photoactive site of channelrhodopsin-2 by DNP-enhanced solid-state NMR spectroscopy.

High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.

Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells.

A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer Cells.

Encoded loop-lanthanide-binding tags for long-range distance measurements in proteins by NMR and EPR spectroscopy.

Influence of Arrestin on the Photodecay of Bovine Rhodopsin.

(19)F-labeling of the adenine H2-site to study large RNAs by NMR spectroscopy.

Fluorescent Dansyl-Guanosine Conjugates that Bind c-MYC Promoter G-Quadruplex and Downregulate c-MYC Expression.

Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.

Corrigendum to "The cytochrome c peroxidase and cytochrome c encounter complex: The other side of the story" [FEBS Lett. 588 (2014) 1873-1878].

Direct ¹³C-detected NMR experiments for mapping and characterization of hydrogen bonds in RNA.

Understanding How DNA Enzymes Work.

Reduced and mutant lysozyme refolding with lipid vesicles. Model study of disulfide impact on equilibria and dynamics.

Synthesis of Fluorescent Binaphthyl Amines That Bind c-MYC G-Quadruplex DNA and Repress c-MYC Expression.

Gd(iii) and Mn(ii) complexes for dynamic nuclear polarization: small molecular chelate polarizing agents and applications with site-directed spin labeling of proteins.

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.

Terphenyl Derivatives from Allantophomopsis lycopodina.

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.

The Absence of the N-acyl-homoserine-lactone Autoinducer Synthase Genes and Increases the Copy Number of the Symbiotic Plasmid in NGR234.

Heteronuclear Cross-Relaxation under Solid-State Dynamic Nuclear Polarization.

Ligand binding to 2΄-deoxyguanosine sensing riboswitch in metabolic context.

Impact of spin label rigidity on extent and accuracy of distance information from PRE data.

Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.

Conformational dynamics and alignment properties of loop lanthanide-binding-tags (LBTs) studied in interleukin-1β.

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation.

Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.

Mistakes in translation: Reflections on mechanism.

Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.

Evaluation of N-detected H-N correlation experiments on increasingly large RNAs.

Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding.

The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.

Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.

Life times of metastable states guide regulatory signaling in transcriptional riboswitches.

Improved high-yield expression, purification and refolding of recombinant mammalian prion proteins under aerosol-free elevated biological safety conditions.

Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex.

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.

The domain architecture of PtkA, the first tyrosine kinase from , differs from the conventional kinase architecture.

Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds.

NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.

Small molecule regulated dynamic structural changes of human G-quadruplexes.

Chemo-Enzymatic Synthesis of Position-Specifically Modified RNA for Biophysical Studies including Light Control and NMR Spectroscopy.

Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging.

A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons.

Combined smFRET and NMR analysis of riboswitch structural dynamics.

Identification of primary and secondary metabolites and transcriptome profile of soybean tissues during different stages of hypoxia.

"CodonWizard" - An intuitive software tool with graphical user interface for customizable codon optimization in protein expression efforts.

Solution Structure and Dynamics of the Small Protein HVO_2922 from Haloferax volcanii.

Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma.

Paramagnetic-iterative relaxation matrix approach: extracting PRE-restraints from NOESY spectra for 3D structure elucidation of biomolecules.

G-Quadruplex-Specific Cell-Permeable Guanosine-Anthracene Conjugate Inhibits Telomere Elongation and Induces Apoptosis by Repressing the Gene.

Genetic Code Expansion Facilitates Position-Selective Labeling of RNA for Biophysical Studies.

Rapid Biophysical Characterization and NMR Spectroscopy Structural Analysis of Small Proteins from Bacteria and Archaea.

Real-Time NMR Spectroscopy for Studying Metabolism.

Conformational Dynamics of Strand Register Shifts in DNA G-Quadruplexes.

Structure Validation of G-Rich RNAs in Noncoding Regions of the Human Genome.

A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR.

Refolding through a Linear Transition State Enables Fast Temperature Adaptation of a Translational Riboswitch.

Site-Specific Detection of Arginine Methylation in Highly Repetitive Protein Motifs of Low Sequence Complexity by NMR.

The conformational landscape of transcription intermediates involved in the regulation of the ZMP-sensing riboswitch from Thermosinus carboxydivorans.

Structural basis for the recognition of transiently structured AU-rich elements by Roquin.

Genetic Code Expansion Facilitates Position-Selective Modification of Nucleic Acids and Proteins.

NMR quality control of fragment libraries for screening.

Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant.

Anti-tyrosinase, anti-cholinesterase and cytotoxic activities of extracts and phytochemicals from the Tunisian Citharexylum spinosum L.: Molecular docking and SAR analysis.

NMR Spectroscopic Characterization of the C-Mannose Conformation in a Thrombospondin Repeat Using a Selective Labeling Approach.

H, C, and N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3e.

Quantitative modeling of the function of kinetically driven transcriptional riboswitches.

F NMR-Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter-Screens.

H, C, and N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b.

NMR Spectroscopy of Large Functional RNAs: From Sample Preparation to Low-Gamma Detection.

Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids.

Site-specific dynamic nuclear polarization in a Gd(III)-labeled protein.

Cysteine oxidation and disulfide formation in the ribosomal exit tunnel.

The Pyrazolo[3,4-]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts.

H, C, and N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10.

Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy.

H,C and N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "the N-terminal domain-SUD-N".

Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia.

H, C, and N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein.

Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide.

H,C and N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "The SUD-M and SUD-C domains".

H, C and N backbone chemical shift assignments of SARS-CoV-2 nsp3a.

H, C and N chemical shift assignment of the stem-loop 5a from the 5'-UTR of SARS-CoV-2.

Synthesis and in Vitro Evaluation of Novel 5-Nitroindole Derivatives as c-Myc G-Quadruplex Binders with Anticancer Activity.

The Folding Landscapes of Human Telomeric RNA and DNA G-Quadruplexes are Markedly Different.

High complexity of Glutamine synthetase regulation in Methanosarcina mazei: Small protein 26 interacts and enhances glutamine synthetase activity.

Magnetization Transfer to Enhance NOE Cross-Peaks among Labile Protons: Applications to Imino-Imino Sequential Walks in SARS-CoV-2-Derived RNAs.

Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9.

H, C, and N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein).

3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs.

Unraveling the Kinetics of Spare-Tire DNA G-Quadruplex Folding.

H, C, N and P chemical shift assignment for stem-loop 4 from the 5'-UTR of SARS-CoV-2.

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.

Insights from Binding on Quadruplex Selective Carbazole Ligands.

Correction to 'Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy'.

Wavelength-Selective Uncaging of Two Different Photoresponsive Groups on One Effector Molecule for Light-Controlled Activation and Deactivation.

Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation.

H, C and N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2.

Oxidative Folding of Proteins: The "Smoking Gun" of Glutathione.

Folding dynamics of polymorphic G-quadruplex structures.