Rei Ukita
Department of Thoracic Surgery,
Department of Cardiac Surgery
Vanderbilt University Medical Center
Rei Ukita is a Research Assistant Professor in the Department of Thoracic Surgery at Vanderbilt University Medical Center (VUMC). He received his undergraduate degree in Biomedical Engineering at Brown University and a PhD in Biomedical Engineering from Carnegie Mellon University. He worked as a postdoctoral research fellow at VUMC prior to his current appointment as research faculty.
Dr. Ukita has worked on small and large animal model systems to test and develop novel extracorporeal support systems. His PhD work focused on biomaterial and drug delivery approaches to reduce the thrombogenicity of artificial lungs. As a postdoctoral fellow, Dr. Ukita developed the large animal model for pulmonary hypertension and right ventricular failure. His current research interests include hemodynamics and molecular mechanisms of right ventricular failure, wearable extracorporeal support systems, and safer anticoagulation therapies for extracorporeal support.
Zwitterionic poly-carboxybetaine coating reduces artificial lung thrombosis in sheep and rabbits.
Acta biomaterialia 07, 2019 | Pubmed ID: 31082571
A Dual-Lumen Bicaval Cannula for Venovenous Extracorporeal Membrane Oxygenation.
The Annals of thoracic surgery 04, 2020 | Pubmed ID: 31863760
Flexions of the Popliteal Artery and the Culture Could Challenge the Outcomes of the Endovascular Procedures.
Annals of vascular diseases Mar, 2020 | Pubmed ID: 32273915
Disposable Component Selection in Extracorporeal Life Support: A Cost Analysis.
ASAIO journal (American Society for Artificial Internal Organs : 1992) Dec, 2020 | Pubmed ID: 33315654
Left Pulmonary Artery Ligation and Chronic Pulmonary Artery Banding Model for Inducing Right Ventricular-Pulmonary Hypertension in Sheep.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 01, 2021 | Pubmed ID: 33346995
Progression Toward Decompensated Right Ventricular Failure in the Ovine Pulmonary Hypertension Model.
ASAIO journal (American Society for Artificial Internal Organs : 1992) Apr, 2021 | Pubmed ID: 33883506
Cross-Circulation for Extracorporeal Liver Support in a Swine Model.
ASAIO journal (American Society for Artificial Internal Organs : 1992) Aug, 2021 | Pubmed ID: 34352819
Acute Normovolemic Hemodilution-assisted Terminal Blood Procurement in Swine for Ex Vivo Organ Perfusion.
Journal of the American Association for Laboratory Animal Science : JAALAS Jan, 2022 | Pubmed ID: 34879898
Large animal preclinical investigation into the optimal extracorporeal life support configuration for pulmonary hypertension and right ventricular failure.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Jul, 2023 | Pubmed ID: 36435685
Technique for xenogeneic cross-circulation to support human donor lungs ex vivo.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Mar, 2023 | Pubmed ID: 36456408
Pulmonary artery banding in sheep: a novel large animal model for congestive hepatopathy.
Journal of applied physiology (Bethesda, Md. : 1985) Apr, 2023 | Pubmed ID: 36759164
Xenogeneic cross-circulation for physiological support and recovery of ex vivo human livers.
Hepatology (Baltimore, Md.) Sep, 2023 | Pubmed ID: 36988383
Immune characterization of a xenogeneic human lung cross-circulation support system.
Science advances Mar, 2023 | Pubmed ID: 37000867
Ambulatory 7-day mechanical circulatory support in sheep model of pulmonary hypertension and right heart failure.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Feb, 2024 | Pubmed ID: 37907183
A Dynamic Sheep Model to Induce Pulmonary Hypertension and Right Ventricular Failure.
Methods in molecular biology (Clifton, N.J.) , 2024 | Pubmed ID: 38676898
Characterization of Porcine Immunoglobulin Deposition in Human Livers Recovered Using a Xenogeneic Cross-Circulation.
ASAIO journal (American Society for Artificial Internal Organs : 1992) Sep, 2024 | Pubmed ID: 39288356
Novel Dynamic Organ Storage System Enhances Liver Graft Function in a Porcine Donation After Circulatory Death Model.
ASAIO journal (American Society for Artificial Internal Organs : 1992) Dec, 2024 | Pubmed ID: 39693205
Antifouling Zwitterionic Polymer Coatings for Blood-Bearing Medical Devices.
Langmuir : the ACS journal of surfaces and colloids Feb, 2025 | Pubmed ID: 39871120
10°C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia reperfusion injury.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Mar, 2025 | Pubmed ID: 40120647
Lung rehabilitation using xenogeneic cross-circulation does not lead to hyperacute rejection in a human lung transplantation model.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Mar, 2025 | Pubmed ID: 40120998
A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
Rei Ukita1,
John W. Stokes1,
W. Kelly Wu1,
Jennifer Talackine1,
Nancy Cardwell1,
Yatrik Patel1,
Clayne Benson5,
Caitlin T. Demarest1,
Erika B. Rosenzweig3,
Keith Cook2,
Emily J. Tsai4,
Matthew Bacchetta1,6
1Department of Thoracic Surgery, Vanderbilt University Medical Center,
2Department of Biomedical Engineering, Carnegie Mellon University,
3Department of Pediatrics, Columbia University Medical Center, Columbia University Irving Medical Center,
4Department of Medicine, Columbia University Medical Center, Columbia University Irving Medical Center,
5Department of Anesthesiology, Vanderbilt University Medical Center,
6Department of Biomedical Engineering, Vanderbilt University
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