Rocky S. Tuan

Detection of periprosthetic infections with use of ribosomal RNA-based polymerase chain reaction.

Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells.

Hypertrophy in mesenchymal stem cell chondrogenesis: effect of TGF-beta isoforms and chondrogenic conditioning.

Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype.

Activin A expression regulates multipotency of mesenchymal progenitor cells.

Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs.

PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes.

Endothelial cell microparticles act as centers of matrix metalloproteinsase-2 (MMP-2) activation and vascular matrix remodeling.

Cytokine expression in muscle following traumatic injury.

Delayed fracture healing in growth differentiation factor 5-deficient mice: a pilot study.

Comparison of minimally invasive direct anterior versus posterior total hip arthroplasty based on inflammation and muscle damage markers.

Stabilization of proteins by nanoencapsulation in sugar-glass for tissue engineering and drug delivery applications.

Biological responses of human mesenchymal stem cells to titanium wear debris particles.

Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head.

Influence of decellularized matrix derived from human mesenchymal stem cells on their proliferation, migration and multi-lineage differentiation potential.

Stem Cell Research & Therapy in 2012.

Mesenchymal progenitor cells derived from traumatized muscle enhance neurite growth.

Mesenchymal stem cell therapy for attenuation of scar formation during wound healing.

The promise and challenges of stem cell-based therapies for skeletal diseases: stem cell applications in skeletal medicine: potential, cell sources and characteristics, and challenges of clinical translation.

Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture.

Polyphenols suppress hydrogen peroxide-induced oxidative stress in human bone-marrow derived mesenchymal stem cells.

Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells.

Concise review: the clinical application of mesenchymal stem cells for musculoskeletal regeneration: current status and perspectives.

Regenerative medicine in 2012: the coming of age of musculoskeletal tissue engineering.

Effect of parathyroid hormone-related protein in an in vitro hypertrophy model for mesenchymal stem cell chondrogenesis.

Three years of Stem Cell Research & Therapy.

The less-often-traveled surface of stem cells: caveolin-1 and caveolae in stem cells, tissue repair and regeneration.

Enhancement of tenogenic differentiation of human adipose stem cells by tendon-derived extracellular matrix.

Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm.

Human mesenchymal stem cells generate a distinct pericellular zone of MMP activities via binding of MMPs and secretion of high levels of TIMPs.

Cellular therapy in bone-tendon interface regeneration.

Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning.

High efficiency transfection of embryonic limb mesenchyme with plasmid DNA using square wave pulse electroporation and sucrose buffer.

Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution.

Functional comparison of human-induced pluripotent stem cell-derived mesenchymal cells and bone marrow-derived mesenchymal stromal cells from the same donor.

Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1β.

Functional cartilage repair capacity of de-differentiated, chondrocyte- and mesenchymal stem cell-laden hydrogels in vitro.

Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases.

Biology of platelet-rich plasma and its clinical application in cartilage repair.

Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors.

Characterization of bone marrow-derived mesenchymal stem cells in aging.

Origin and function of cartilage stem/progenitor cells in osteoarthritis.

Lizard tail regeneration: regulation of two distinct cartilage regions by Indian hedgehog.

Fiber diameter and seeding density influence chondrogenic differentiation of mesenchymal stem cells seeded on electrospun poly(ε-caprolactone) scaffolds.

Platelet-Rich Plasma Inhibits Mechanically Induced Injury in Chondrocytes.

Molecular diagnostics.

In Vitro Repair of Meniscal Radial Tear Using Aligned Electrospun Nanofibrous Scaffold.

Development of a Spring-Loaded Impact Device to Deliver Injurious Mechanical Impacts to the Articular Cartilage Surface.

Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering.

Stem Cells in Skeletal Tissue Engineering: Technologies and Models.

Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study.

Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling.

Promotion of human mesenchymal stem cell osteogenesis by PI3-kinase/Akt signaling, and the influence of caveolin-1/cholesterol homeostasis.

Expression of Concern: Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure.

Nascent osteoblast matrix inhibits osteogenesis of human mesenchymal stem cells in vitro.

Antibiotic-tolerant Staphylococcus aureus Biofilm Persists on Arthroplasty Materials.

Polymerase Chain Reaction molecular diagnostic technology for monitoring chronic osteomyelitis.

Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering.

From embryonic development to human diseases: The functional role of caveolae/caveolin.

Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration.

Catabolic effects of endothelial cell-derived microparticles on disc cells: Implications in intervertebral disc neovascularization and degeneration.

Prenatal substance use and developmental disorders: Overview and highlights.

Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration.

Lizard tail regeneration as an instructive model of enhanced healing capabilities in an adult amniote.

Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies.

Augmented repair of radial meniscus tear with biomimetic electrospun scaffold: an in vitro mechanical analysis.

Rapidly dissociated autologous meniscus tissue enhances meniscus healing: An in vitro study.

Prenatal exposure to environmental factors and congenital limb defects.

Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-β3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells.

Anatomical region-dependent enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix.

Region-Specific Effect of the Decellularized Meniscus Extracellular Matrix on Mesenchymal Stem Cell-Based Meniscus Tissue Engineering.

A unified birth defects research.

Efficacy of thermoresponsive, photocrosslinkable hydrogels derived from decellularized tendon and cartilage extracellular matrix for cartilage tissue engineering.

Birth Defects: Etiology, screening, and detection.

Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells.

Chondrogenesis of human bone marrow mesenchymal stem cells in 3-dimensional, photocrosslinked hydrogel constructs: Effect of cell seeding density and material stiffness.

One-Step Fabrication of Bone Morphogenetic Protein-2 Gene-Activated Porous Poly-L-Lactide Scaffold for Bone Induction.

Neurotrophic support by traumatized muscle-derived multipotent progenitor cells: Role of endothelial cells and Vascular Endothelial Growth Factor-A.

Cartilage and Muscle Cell Fate and Origins during Lizard Tail Regeneration.

Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production.

Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo.

3D uniaxial mechanical stimulation induces tenogenic differentiation of tendon-derived stem cells through a PI3K/AKT signaling pathway.

Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells.

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology.

TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW.

Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing.

Musculoskeletal regeneration research network: A global initiative.

Effect of Platelet-Rich Plasma on Chondrogenic Differentiation of Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells.

Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders.

Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-β.

Enhanced repair of meniscal hoop structure injuries using an aligned electrospun nanofibrous scaffold combined with a mesenchymal stem cell-derived tissue engineered construct.

Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt/β-catenin pathway.

Conduits harnessing spatially controlled cell-secreted neurotrophic factors improve peripheral nerve regeneration.

Optimization of photocrosslinked gelatin/hyaluronic acid hybrid scaffold for the repair of cartilage defect.

A Bioactive Cartilage Graft of IGF1-Transduced Adipose Mesenchymal Stem Cells Embedded in an Alginate/Bovine Cartilage Matrix Tridimensional Scaffold.

Role of NGF-TrkA signaling in calcification of articular chondrocytes.

Robust bone regeneration through endochondral ossification of human mesenchymal stem cells within their own extracellular matrix.

Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold.

Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production.

A Cellularized Biphasic Implant Based on a Bioactive Silk Fibroin Promotes Integration and Tissue Organization during Osteochondral Defect Repair in a Porcine Model.

Modeling appendicular skeletal cartilage development with modified high-density micromass cultures of adult human bone marrow-derived mesenchymal progenitor cells.

Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs.

Incorporating silica-coated graphene in bioceramic nanocomposites to simultaneously enhance mechanical and biological performance.

Acceleration of chondrogenic differentiation of human mesenchymal stem cells by sustained growth factor release in 3D graphene oxide incorporated hydrogels.

Chondroinductive factor-free chondrogenic differentiation of human mesenchymal stem cells in graphene oxide-incorporated hydrogels.

TGF-β1 plays a protective role in glucocorticoid-induced dystrophic calcification.

Tendon-derived extracellular matrix induces mesenchymal stem cell tenogenesis via an integrin/transforming growth factor-β crosstalk-mediated mechanism.

Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional Bone Model.

Gel and cells: A promising reparative strategy for degenerated intervertebral discs.

Condensation-Driven Chondrogenesis of Human Mesenchymal Stem Cells within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical Properties.

Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus.

Adipose Tissue-Derived Stem Cells Retain Their Adipocyte Differentiation Potential in Three-Dimensional Hydrogels and Bioreactors .

Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models.

Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice.

Mechanism of traumatic heterotopic ossification: In search of injury-induced osteogenic factors.

Dead muscle tissue promotes dystrophic calcification by lowering circulating TGF-β1 level.

Current Models for Development of Disease-Modifying Osteoarthritis Drugs.

Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling.

Enhancing the potential of aged human articular chondrocytes for high-quality cartilage regeneration.

Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries.

Development of a large animal rabbit model for chronic periprosthetic joint infection.

An in vitro chondro-osteo-vascular triphasic model of the osteochondral complex.

The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles.

Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells.

Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling.

A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-Physiological Loads.

Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway.

Dextran sulfate-amplified extracellular matrix deposition promotes osteogenic differentiation of mesenchymal stem cells.

Macrophages Modulate the Function of MSC- and iPSC-Derived Fibroblasts in the Presence of Polyethylene Particles.

Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing.

Tenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: composition and transcriptomic analyses.

Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models.

Aberrant Expression of and in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors.

Towards establishing human body-on-a-chip systems.

Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential.

Polyphenols suppress inducible oxidative stress in human osteoarthritic and bovine chondrocytes.

Clinical Applications of Bone Tissue Engineering in Orthopedic Trauma.