New Jersey Institute of Technology

7 ARTICLES PUBLISHED IN JoVE

Neuroscience

VisualEyes: A Modular Software System for Oculomotor Experimentation

¹Department of Biomedical Engineering, New Jersey Institute of Technology

Neural control and cognitive processes can be studied through eye movements. The VisualEyes software allows an operator to program stimuli on two computer screens independently using a simple, custom scripting language. The system can stimulate tandem eye movements (saccades and smooth pursuit) or opposing eye movements (vergence) or any combination.

Bioengineering

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

Joseph R. Loverde^1,2, Rosa E. Tolentino^1,2, Bryan J. Pfister¹

¹Departments of Biomedical Engineering, New Jersey Institute of Technology, ²Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey

A unique tissue engineering method was developed to elongate numerous nerve fibers in culture by recapitulating axon stretch growth; a form of nervous system growth whereby nerves elongate in conjunction with growth of the enlarging body.

Bioengineering

Culturing Mouse Cardiac Valves in the Miniature Tissue Culture System

Boudewijn P.T. Kruithof¹, Samuel C. Lieber², Marianna Kruithof-de Julio³, Vincian Gaussin⁴, Marie José Goumans¹

¹Department of Molecular Cell Biology, Leiden University Medical Center, ²Department of Engineering Technology, New Jersey Institute of Technology, ³Department of Urology, Leiden University Medical Center, ⁴Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School

Here, we present an ex vivo flow model in which murine cardiac valves can be cultured allowing the study of the biology of the valve.

Bioengineering

A Versatile Method of Patterning Proteins and Cells

Anil B. Shrirao^*1, Frank H. Kung^*2, Derek Yip³, Bonnie L. Firestein², Cheul H, Cho³, Ellen Townes-Anderson⁴

¹Department of Biomedical Engineering, Rutgers University, ²Department of Cell Biology and Neuroscience, Rutgers University, ³Department of Biomedical Engineering, New Jersey Institute of Technology, ⁴Department of Pharmacology, Physiology, and Neuroscience, Rutgers New Jersey Medical School

This report describes a simple, easy to perform technique, using low pressure vacuum, to fill microfluidic channels with cells and substrates for biological research.

Medicine

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap

Yee-Shuan Lee¹, Siliang Wu², Treena Livingston Arinzeh³, Mary Bartlett Bunge^1,4,5

¹The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, ²Department of Materials Science and Engineering, New Jersey Institute of Technology, ³Department of Biomedical Engineering, New Jersey Institute of Technology, ⁴Department of Cell Biology, University of Miami Miller School of Medicine, ⁵Department of Neurological Surgery, University of Miami Miller School of Medicine

This article describes a technique to insert a hollow conduit between the spinal cord stumps after complete transection and fill with Schwann cells (SCs) and injectable basement membrane matrix in order to bridge and promote axon regeneration across the gap.

Chemistry

Probing Surface Electrochemical Activity of Nanomaterials using a Hybrid Atomic Force Microscope-Scanning Electrochemical Microscope (AFM-SECM)

Xiaonan Shi¹, Qingquan Ma¹, Taha Marhaba¹, Wen Zhang¹

¹Department of Civil and Environmental Engineering, New Jersey Institute of Technology

Atomic force microscopy (AFM) combined with scanning electrochemical microscopy (SECM), namely, AFM-SECM, can be used to simultaneously acquire high-resolution topographical and electrochemical information on material surfaces at nanoscale. Such information is critical to understanding heterogeneous properties (e.g., reactivity, defects, and reaction sites) on local surfaces of nanomaterials, electrodes and biomaterials.

Bioengineering

Quantification of Oculomotor Responses and Accommodation Through Instrumentation and Analysis Toolboxes

Sebastian N. Fine¹, Yi Guo^1,2, Henry Talasan¹, Stephen LeStrange¹, Chang Yaramothu^1,3, Tara L. Alvarez¹

¹Department of Biomedical Engineering, New Jersey Institute of Technology, ²Neural Automations Ltd., ³School of Applied Engineering and Technology, New Jersey Institute of Technology

VisualEyes2020 (VE2020) is a custom scripting language that presents, records, and synchronizes visual eye movement stimuli. VE2020 provides stimuli for conjugate eye movements (saccades and smooth pursuit), disconjugate eye movements (vergence), accommodation, and combinations of each. Two analysis programs unify the data processing from the eye tracking and accommodation recording systems.