Pier Lorenzo Puri

Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases.

Activation of MyoD-dependent transcription by cdk9/cyclin T2.

A myogenic differentiation checkpoint activated by genotoxic stress.

Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma.

Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin.

Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300.

Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin.

p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci.

Differentiation-induced radioresistance in muscle cells.

Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells.

Signaling to the chromatin during skeletal myogenesis: novel targets for pharmacological modulation of gene expression.

The epigenetic network regulating muscle development and regeneration.

MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions.

p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.

A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate.

DNA damage and cellular differentiation: more questions than responses.

Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.

The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis.

Epigenetic drugs in the treatment of skeletal muscle atrophy.

Regenerative pharmacology in the treatment of genetic diseases: the paradigm of muscular dystrophy.

HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment.

Nitric oxide deficiency determines global chromatin changes in Duchenne muscular dystrophy.

Chromatin: the interface between extrinsic cues and the epigenetic regulation of muscle regeneration.

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.

Switch NFix developmental myogenesis.

HDACs and sirtuins: targets for new pharmacological interventions in human diseases.

SWI/SNF complexes, chromatin remodeling and skeletal myogenesis: it's time to exchange!

Epigenetic regulation of skeletal myogenesis.

TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.

An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis.

Selective control of Pax7 expression by TNF-activated p38α/polycomb repressive complex 2 (PRC2) signaling during muscle satellite cell differentiation.

Differentiation of human rhabdomyosarcoma RD cells is regulated by reciprocal, functional interactions between myostatin, p38 and extracellular regulated kinase signalling pathways.

Histone deacetylase inhibitors in the treatment of muscular dystrophies: epigenetic drugs for genetic diseases.

Phosphoryl-EZH-ion.

Coordination of cell cycle, DNA repair and muscle gene expression in myoblasts exposed to genotoxic stress.

Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells.

Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex.

SIRT1 signaling as potential modulator of skeletal muscle diseases.

Epigenetic control of reprogramming and cellular differentiation.

Myosin phosphatase modulates the cardiac cell fate by regulating the subcellular localization of Nkx2.5 in a Wnt/Rho-associated protein kinase-dependent pathway.

BAF60 A, B, and Cs of muscle determination and renewal.

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.

Epigenetic reprogramming of human embryonic stem cells into skeletal muscle cells and generation of contractile myospheres.

Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice.

Preclinical studies in the mdx mouse model of duchenne muscular dystrophy with the histone deacetylase inhibitor givinostat.

Epigenetic control of skeletal muscle regeneration: Integrating genetic determinants and environmental changes.

Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment.

Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS.

"Mix of Mics"- Phenotypic and Biological Heterogeneity of "Multipotent" Muscle Interstitial Cells (MICs).

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.

Nitric oxide and histone acetylation-shaping craniofacial development.

Redox or death: checking on fetal myogenesis.