George R. Douglas

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big Blue rat mammary epithelial and fibroblast cells.

Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts.

Treatment and sampling protocols for transgenic mutation assays.

In vivo transgenic mutation assays.

Development and characterization of a stable epithelial cell line from Muta Mouse lung.

Comprehensive comparison of six microarray technologies.

Molecular insight into the effects of hypothyroidism on the developing cerebellum.

Automation of cDNA microarray hybridization and washing yields improved data quality.

A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells.

Detailed review of transgenic rodent mutation assays.

Assessment of 3-nitrobenzanthrone reductase activity in mammalian tissues by normal-phase HPLC with fluorescence detection.

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid.

Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays.

Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray.

Hepatic gene expression changes in hypothyroid juvenile mice: characterization of a novel negative thyroid-responsive element.

Mainstream tobacco smoke causes paternal germ-line DNA mutation.

Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta mouse lung epithelial cells.

Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field.

Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.

Mutagenic and carcinogenic hazards of settled house dust. I: Polycyclic aromatic hydrocarbon content and excess lifetime cancer risk from preschool exposure.

Mutagenic and carcinogenic hazards of settled house dust. II: Salmonella mutagenicity.

Tissue-specific metabolic activation and mutagenicity of 3-nitrobenzanthrone in MutaMouse.

Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse.

Toxicogenomic analysis of mainstream tobacco smoke-exposed mice reveals repression of plasminogen activator inhibitor-1 gene in heart.

Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme.

The genotoxicity of mainstream and sidestream marijuana and tobacco smoke condensates.

Induction of lacZ mutations in MutaMouse primary hepatocytes.

Characterisation of Muta™Mouse λgt10-lacZ transgene: evidence for in vivo rearrangements.

New and emerging technologies for genetic toxicity testing.

Mutation spectrum in FE1-MUTA(TM) Mouse lung epithelial cells exposed to nanoparticulate carbon black.

Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice.

Suitable top concentration for tests with mammalian cells: mouse lymphoma assay workgroup.

Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse.

Harnessing genomics to identify environmental determinants of heritable disease.

The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development.

No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea.