Thomas Oellerich

SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins.

The B-lymphoid Grb2 interaction code.

Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells.

Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.

B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.

The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.

Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.

β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.

Cutting edge: feed-forward activation of phospholipase Cγ2 via C2 domain-mediated binding to SLP65.

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation.

Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.

FLT3-ITD and TLR9 employ Bruton's tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation.