Department of Hematology/Oncology
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SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins.
Molecular & cellular proteomics : MCP Jul, 2009 | Pubmed ID: 19372136
The B-lymphoid Grb2 interaction code.
Immunological reviews Nov, 2009 | Pubmed ID: 19909361
Fc gamma receptor IIb modulates the molecular Grb2 interaction network in activated B cells.
Cellular signalling May, 2011 | Pubmed ID: 21262349
Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.
European journal of immunology Jun, 2011 | Pubmed ID: 21469132
B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.
Immunity Jun, 2011 | Pubmed ID: 21703542
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.
The EMBO journal Aug, 2011 | Pubmed ID: 21725281
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.
The EMBO journal Aug, 2011 | Pubmed ID: 21822214
The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23223229
Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.
PloS one , 2012 | Pubmed ID: 23285124
β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.
Blood May, 2013 | Pubmed ID: 23509157
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.
Nature immunology Sep, 2013 | Pubmed ID: 23913047
Cutting edge: feed-forward activation of phospholipase Cγ2 via C2 domain-mediated binding to SLP65.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2013 | Pubmed ID: 24166973
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.
Blood Jun, 2014 | Pubmed ID: 24802772
PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation.
Nature communications , 2014 | Pubmed ID: 24874575
Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.
Cellular signalling Jan, 2015 | Pubmed ID: 25452106
FLT3-ITD and TLR9 employ Bruton's tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation.
Blood Jan, 2015 | Pubmed ID: 25605370
Hanibal Bohnenberger1,
Philipp Ströbel1,
Sebastian Mohr2,
Jasmin Corso3,
Tobias Berg2,
Henning Urlaub3,4,
Christof Lenz3,4,
Hubert Serve2,5,6,
Thomas Oellerich2,5,6
1Institute of Pathology, University Medical Center, Göttingen,
2Department of Hematology/Oncology, Goethe University of Frankfurt,
3Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry,
4Bioanalytics, Institute of Clinical Chemistry, University Medical Center, Göttingen,
5, German Cancer Consortium,
6, German Cancer Research Center
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