Wolfgang W. A. Schamel

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.

Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop.

Initiation of TCR signaling: regulation within CD3 dimers.

A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum.

Two-dimensional Blue native/SDS gel electrophoresis of multi-protein complexes from whole cellular lysates: a proteomics approach.

Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes.

Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors.

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.

Subproteomic analysis of metal-interacting proteins in human B cells.

Differences in pairing and cluster formation of T cell receptor alpha- and beta-chains in T cell clones and fusion hybridomas.

Two dimensional Blue Native-/SDS-PAGE analysis of SLP family adaptor protein complexes.

A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex.

T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.

Blue native polyacrylamide gel electrophoresis (BN-PAGE) for the identification and analysis of multiprotein complexes.

Identification of disulfide bonds in the Ig-alpha/Ig-beta component of the B cell antigen receptor using the Drosophila S2 cell reconstitution system.

Overlapping functions of human CD3delta and mouse CD3gamma in alphabeta T-cell development revealed in a humanized CD3gamma-mouse.

Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry.

A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multiprotein complexes.

Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.

The TCR binding site does move.

A permissive geometry model for TCR-CD3 activation.

The short length of the extracellular domain of zeta is crucial for T cell antigen receptor function.

The extracellular part of zeta is buried in the T cell antigen receptor complex.

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation.

Two-dimensional blue native polyacrylamide gel electrophoresis.

Differential antibody binding to the surface alphabetaTCR.CD3 complex of CD4+ and CD8+ T lymphocytes is conserved in mammals and associated with differential glycosylation.

Purification of the T cell antigen receptor and analysis by blue-native PAGE.

Clustering models.

Segregation models.

Permissive geometry model.

Detection of protein complex interactions via a Blue Native-PAGE retardation assay.

Target-dependent T-cell activation by coligation with a PSMA x CD3 diabody induces lysis of prostate cancer cells.

Models of antigen receptor activation in the design of vaccines.

Analysis of novel phospho-ITAM specific antibodies in a S2 reconstitution system for TCR-CD3 signalling.

Detection of phosphorylated T and B cell antigen receptor species by Phos-tag SDS- and Blue Native-PAGE.

Low-valency, but not monovalent, antigens trigger the B-cell antigen receptor (BCR).

Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes.

Pre-clustered TCR complexes.

Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks.

A new vampire saga: the molecular mechanism of T cell trogocytosis.

Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.

A leaky mutation in CD3D differentially affects αβ and γδ T cells and leads to a Tαβ-Tγδ+B+NK+ human SCID.