Malcolm P. Logan

Tbx5 is required for forelimb bud formation and continued outgrowth.

Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth.

Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo.

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth.

Tbx5 is dispensable for forelimb outgrowth.

Conservation of linkage and evolution of developmental function within the Tbx2/3/4/5 subfamily of T-box genes: implications for the origin of vertebrate limbs.

Tbx4/5 gene duplication and the origin of vertebrate paired appendages.

Tbx4 and tbx5 acting in connective tissue are required for limb muscle and tendon patterning.

The secreted integrin ligand nephronectin is necessary for forelimb formation in Xenopus tropicalis.

Regulation of limb bud initiation and limb-type morphology.

1, 2, 3: counting the fingers on a chicken wing.

Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control.

Hox genes regulate the onset of Tbx5 expression in the forelimb.

A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity.

Regulatory modulation of the T-box gene Tbx5 links development, evolution, and adaptation of the sternum.

RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation.

Subdivision of the lateral plate mesoderm and specification of the forelimb and hindlimb forming domains.