Victor M. Darley-Usmar

Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress.

Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase.

Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide.

High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes.

Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species.

Obesity, aerobic exercise, and vascular disease: the role of oxidant stress.

Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species.

Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide.

S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation.

Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide.

Cytoprotection against oxidative stress and the regulation of glutathione synthesis.

Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide.

Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells.

Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: a novel class of biological metabolites.

Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition.

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.

Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties.

Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins.

Control of the nitric oxide-cytochrome c oxidase signaling pathway under pathological and physiological conditions.

Mechanisms of the interaction of nitroxyl with mitochondria.

L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia.

Weight loss and race modulate nitric oxide metabolism in overweight women.

The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice.

Human glutamate cysteine ligase gene regulation through the electrophile response element.

Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway.

Redox signalling: from nitric oxide to oxidized lipids.

Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells.

Nitric oxide signaling gone awry: nitration of glutamine synthetase and hyperammonemia in sepsis.

Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues.

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.

Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria.

Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species.

Metabolism of phytoestrogen conjugates.

A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress.

Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells.

Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells.

Hydrogen sulfide mediates vasoactivity in an O2-dependent manner.

Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration.

Methods for measuring the regulation of respiration by nitric oxide.

Is the soluble guanylate cyclase pathway the only one available for nitric oxide (NO) signaling?

Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk.

Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide.

Hydrogen sulfide mediates the vasoactivity of garlic.

Proteomic approaches to identify and characterize alterations to the mitochondrial proteome in alcoholic liver disease.

Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.

S-nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning.

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo.

Methods for imaging and detecting modification of proteins by reactive lipid species.

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal.

Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms.

Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation.

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species.

Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor.

What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology.

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation.

Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.

PYK2 信号时需要依赖于血小板衍生生长因子的血管平滑肌细胞增殖。

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis.

Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells.

Assessing bioenergetic function in response to oxidative stress by metabolic profiling.

Protein O-linked β-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function.

Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.

Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes.

Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy.

The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function.

Cell signalling by reactive lipid species: new concepts and molecular mechanisms.

Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products.

Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death.

Integration of cellular bioenergetics with mitochondrial quality control and autophagy.

Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood.

Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cells.

Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.

Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse.

Lipid metabolites enhance secretion acting on SNARE microdomains and altering the extent and kinetics of single release events in bovine adrenal chromaffin cells.

Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells.

A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers.