Graduate School of Medicine
Jae Young Seong, Professor
Lab of GPCR
Graduate School of Meical Sciences, Korea University
Seoul
Republic of KOREA
e-mail: jyseong@korea.ac.kr
Homepage: www.gpcr.or.kr
The accessory proteins REEP5 and REEP6 refine CXCR1-mediated cellular responses and lung cancer progression.
Scientific reports 12, 2016 | Pubmed ID: 27966653
Cellular and molecular biology of orphan G protein-coupled receptors.
International review of cytology , 2006 | Pubmed ID: 16984818
Molecular evolution of neuropeptide receptors with regard to maintaining high affinity to their authentic ligands.
General and comparative endocrinology Aug-Sep, 2007 | Pubmed ID: 17286976
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.
Molecular and cellular biology Aug, 2007 | Pubmed ID: 17526737
Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13.
Molecular and cellular endocrinology Oct, 2007 | Pubmed ID: 17825479
Extracellular loop 3 (ECL3) and ECL3-proximal transmembrane domains VI and VII of the mesotocin and vasotocin receptors confer differential ligand selectivity and signaling activity.
General and comparative endocrinology Mar, 2008 | Pubmed ID: 18158152
Involvement of amino acids flanking Glu7.32 of the gonadotropin-releasing hormone receptor in the selectivity of antagonists.
Molecules and cells Feb, 2008 | Pubmed ID: 18319619
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.
The Journal of biological chemistry Jul, 2008 | Pubmed ID: 18499677
Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin.
Peptides Jan, 2009 | Pubmed ID: 18550222
GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase.
Cellular signalling Nov, 2008 | Pubmed ID: 18755269
Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates.
Endocrinology Jun, 2009 | Pubmed ID: 19164475
A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells.
Cancer research Feb, 2009 | Pubmed ID: 19176390
Nova-1 mediates glucocorticoid-induced inhibition of pre-mRNA splicing of gonadotropin-releasing hormone transcripts.
The Journal of biological chemistry May, 2009 | Pubmed ID: 19282286
Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates.
Annals of the New York Academy of Sciences Apr, 2009 | Pubmed ID: 19456337
Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis.
Journal of cancer research and clinical oncology Jan, 2010 | Pubmed ID: 19572147
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.
Cellular signalling Nov, 2010 | Pubmed ID: 20600852
Molecular coevolution of kisspeptins and their receptors from fish to mammals.
Annals of the New York Academy of Sciences Jul, 2010 | Pubmed ID: 20633134
Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors.
Molecules and cells Aug, 2010 | Pubmed ID: 20799012
Revisiting the evolution of gonadotropin-releasing hormones and their receptors in vertebrates: secrets hidden in genomes.
General and comparative endocrinology Jan, 2011 | Pubmed ID: 21036176
Regulation of IκB kinase by GβL through recruitment of the protein phosphatases.
Molecules and cells Dec, 2010 | Pubmed ID: 21110129
Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.
American journal of physiology. Endocrinology and metabolism Aug, 2011 | Pubmed ID: 21521715
Class-C SOX transcription factors control GnRH gene expression via the intronic transcriptional enhancer.
Molecular endocrinology (Baltimore, Md.) Jul, 2011 | Pubmed ID: 21527504
Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.
The Journal of biological chemistry Jul, 2011 | Pubmed ID: 21622564
Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1.
Molecules and cells Oct, 2011 | Pubmed ID: 21904878
Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-induced receptor activation.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22105074
Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors.
Frontiers in neuroscience , 2012 | Pubmed ID: 22291614
Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides.
Frontiers in endocrinology , 2012 | Pubmed ID: 22654849
Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum.
Molecules and cells Sep, 2012 | Pubmed ID: 22843118
Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signaling.
PloS one , 2012 | Pubmed ID: 23028510
CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid.
Journal of cellular biochemistry May, 2013 | Pubmed ID: 23161284
Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction.
Frontiers in endocrinology , 2012 | Pubmed ID: 23181056
Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication.
Molecular biology and evolution May, 2013 | Pubmed ID: 23427277
Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23509283
A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates.
PloS one , 2013 | Pubmed ID: 23776481
Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2013 | Pubmed ID: 23980168
Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor.
PloS one , 2014 | Pubmed ID: 24498396
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
Endocrinology May, 2014 | Pubmed ID: 24517231
Molecular evolution of GPCRs: GLP1/GLP1 receptors.
Journal of molecular endocrinology Jun, 2014 | Pubmed ID: 24598200
Neuropeptide GPCRs in Neuroendocrinology.
Frontiers in endocrinology , 2014 | Pubmed ID: 24772105
Identification of a novel insect neuropeptide, CNMa and its receptor.
FEBS letters Jun, 2014 | Pubmed ID: 24796791
A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ.
The Journal of biological chemistry Jun, 2014 | Pubmed ID: 24811176
Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist.
PloS one , 2014 | Pubmed ID: 24926857
Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?
Frontiers in endocrinology , 2014 | Pubmed ID: 25165463
A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth.
Endocrinology and metabolism (Seoul, Korea) Sep, 2014 | Pubmed ID: 25309791
Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.
The Journal of biological chemistry Feb, 2015 | Pubmed ID: 25561730
Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation.
Molecular and cellular endocrinology Feb, 2015 | Pubmed ID: 25583361
Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity.
Cellular signalling Nov, 2015 | Pubmed ID: 26296658
Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily.
Molecular biology and evolution Nov, 2015 | Pubmed ID: 26337547
NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells.
Journal of cellular biochemistry Jun, 2016 | Pubmed ID: 26565392
Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice.
Scientific reports Feb, 2016 | Pubmed ID: 26907960
Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling.
Molecules and cells May, 2016 | Pubmed ID: 27094059
Distribution of galanin receptor 2b neurons and interaction with galanin in the zebrafish central nervous system.
Neuroscience letters 08, 2016 | Pubmed ID: 27315774
Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors.
Biomolecules & therapeutics Jan, 2017 | Pubmed ID: 28035082
GABBR2 mutations determine phenotype in rett syndrome and epileptic encephalopathy.
Annals of neurology Sep, 2017 | Pubmed ID: 28856709
FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.
Scientific reports Nov, 2017 | Pubmed ID: 29138422
Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells.
Archives of pharmacal research Feb, 2018 | Pubmed ID: 29196918
mRNA expression and metabolic regulation of npy and agrp1/2 in the zebrafish brain.
Neuroscience letters 03, 2018 | Pubmed ID: 29329911
Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility.
Biochemical pharmacology May, 2018 | Pubmed ID: 29522713
Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor.
Communications biology , 2018 | Pubmed ID: 30272007
Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS.
Scientific reports Mar, 2019 | Pubmed ID: 30903017
SP-8356, a (1S)-(-)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signaling.
Scientific reports Apr, 2019 | Pubmed ID: 31036845
Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight.
Frontiers in neuroscience , 2019 | Pubmed ID: 31057364