Manabu Tokeshi

Fabrication of functionalized double-lamellar multifunctional envelope-type nanodevices using a microfluidic chip with a chaotic mixer array.

A method of cryoprotection for protein crystallography by using a microfluidic chip and its application for in situ X-ray diffraction measurements.

Arrangement of a nanostructure array to control equilibrium and nonequilibrium transports of macromolecules.

A microfluidic cell culture system for monitoring of sequential changes in endothelial cells after heat stress.

An instrument-free, screen-printed paper microfluidic device that enables bio and chemical sensing.

Fluorescence polarization measurement system using a liquid crystal layer and an image sensor.

A Portable Liquid Chromatograph with a Battery-operated Compact Electroosmotic Pump and a Microfluidic Chip Device with a Reversed Phase Packed Column.

Microfluidic Approaches for Protein Crystal Structure Analysis.

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery.

3,3',5,5'-Tetramethylbenzidine Oxidation on Paper Devices for Horseradish Peroxidase-based Assays.

Label-free detection of real-time DNA amplification using a nanofluidic diffraction grating.

Novel concept of washing for microfluidic paper-based analytical devices based on capillary force of paper substrates.

Image analysis for a microfluidic paper-based analytical device using the CIE L*a*b* color system.

A competitive immunoassay system for microfluidic paper-based analytical detection of small size molecules.

An immuno-wall microdevice exhibits rapid and sensitive detection of IDH1-R132H mutation specific to grade II and III gliomas.

Rapid Detection of Cat Cystatin C (cCys-C) Using Immuno-Pillar Chips.

Fabrication and Evaluation of Microfluidic Immunoassay Devices with Antibody-Immobilized Microbeads Retained in Porous Hydrogel Micropillars.

A millisecond micro-RNA separation technique by a hybrid structure of nanopillars and nanoslits.

Using Laser Interference Lithography in the Fabrication of a Simplified Micro- and Nanofluidic Device for Label-free Detection.

Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers.

Characteristics of Microfluidic Paper-based Analytical Devices Fabricated by Four Different Methods.

A compact fluorescence polarization analyzer with high-transmittance liquid crystal layer.

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems.

Microfluidic Devices for Drug Delivery Systems.

Advances in Microfluidic Paper-Based Analytical Devices for Food and Water Analysis.

Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment.

Micro/Nano Devices for Chemical Analysis.

Recent Microdevice-Based Aptamer Sensors.

Development of a microdevice for facile analysis of theophylline in whole blood by a cloned enzyme donor immunoassay.

Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo.

The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria.

Ultrasensitive detection of disease biomarkers using an immuno-wall device with enzymatic amplification.

High-throughput fluorescence polarization immunoassay by using a portable fluorescence polarization imaging analyzer.

An Electrochemical Sensor Based on Structure Switching of Dithiol-modified Aptamer for Simple Detection of Ochratoxin A.

A paper-based analytical device coupled with electrochemical detection for the determination of dexamethasone and prednisolone in adulterated traditional medicines.

Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery.

Rapid, Sensitive, and Selective Detection of H5 Hemagglutinin from Avian Influenza Virus Using an Immunowall Device.

Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles.

The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution.

Paper-Based Device for the Facile Colorimetric Determination of Lithium Ions in Human Whole Blood.

Rapid detection of anti-H5 avian influenza virus antibody by fluorescence polarization immunoassay using a portable fluorescence polarization analyzer.

Observation of Ethanol-Induced Condensation and Decondensation Processes at a Single-DNA Molecular Level in Microfluidic Devices Equipped with a Rapid Solution Exchange System.

Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to siRNA Delivery.

Real-Time Measurement of Protein Crystal Growth Rates within the Microfluidic Device to Understand the Microspace Effect.

The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery.

Noncompetitive Fluorescence Polarization Immunoassay for Protein Determination.

Development of an immuno-wall device for the rapid and sensitive detection of EGFR mutations in tumor tissues resected from lung cancer patients.

Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol).

Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition.

Rapid, sensitive universal paper-based device enhances competitive immunoassays of small molecules.

Non-competitive fluorescence polarization immunoassay for detection of H5 avian influenza virus using a portable analyzer.

Dip-Type Paper-Based Analytical Device for Straightforward Quantitative Detection without Precise Sample Introduction.

Simple Approach for Fluorescence Signal Amplification Utilizing a Poly(vinyl alcohol)-Based Polymer Structure in a Microchannel.

Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material.

Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein-ligand complex structure analysis.

Facile and rapid detection of SARS-CoV-2 antibody based on a noncompetitive fluorescence polarization immunoassay in human serum samples.

Determination of blood lithium-ion concentration using digital microfluidic whole-blood separation and preloaded paper sensors.

Microchip Immunoassays for Monitoring Renal Function: Rapid, Low-Cost, and Highly Sensitive Quantification of Urinary Biomarkers of Diabetic Nephropathy.

Electrochemical enzyme-based blood ATP and lactate sensor for a rapid and straightforward evaluation of illness severity.

Topology-Dependent Interaction of Cyclic Poly(ethylene glycol) Complexed with Gold Nanoparticles against Bovine Serum Albumin for a Colorimetric Change.

Paper-Based Analytical Device for the On-Site Detection of Nerve Agents.

One-Step Production Using a Microfluidic Device of Highly Biocompatible Size-Controlled Noncationic Exosome-like Nanoparticles for RNA Delivery.

Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery.

Enzyme kinetics in confined geometries at the single enzyme level.

Dimethoxytriadinylation LC-MS/MS of Novichok A-Series Degradation Products in Human Urine.