Hanbin Mao

ILPR G-quadruplexes formed in seconds demonstrate high mechanical stabilities.

Direct experimental evidence for quadruplex-quadruplex interaction within the human ILPR.

ILPR repeats adopt diverse G-quadruplex conformations that determine insulin binding.

Coexistence of an ILPR i-motif and a partially folded structure with comparable mechanical stability revealed at the single-molecule level.

Detection of single nucleotide polymorphism using tension-dependent stochastic behavior of a single-molecule template.

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.

Intramolecular folding in three tandem guanine repeats of human telomeric DNA.

Tertiary DNA Structure in the Single-Stranded hTERT Promoter Fragment Unfolds and Refolds by Parallel Pathways via Cooperative or Sequential Events.

Single-molecule measurements of the binding between small molecules and DNA aptamers.

G-quadruplex and i-motif are mutually exclusive in ILPR double-stranded DNA.

Intramolecular folding in human ILPR fragment with three C-rich repeats.

Click chemistry assisted single-molecule fingerprinting reveals a 3D biomolecular folding funnel.

Long-Loop G-Quadruplexes are Misfolded Population Minorities with Fast Transition Kinetics in Human Telomeric Sequences.

Non-B DNA structures show diverse conformations and complex transition kinetics comparable to RNA or proteins--a perspective from mechanical unfolding and refolding experiments.

Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions.

Mechanochemical properties of individual human telomeric RNA (TERRA) G-quadruplexes.

Controlled particle collision leads to direct observation of docking and fusion of lipid droplets in an optical trap.

Yoctoliter thermometry for single-molecule investigations: a generic bead-on-a-tip temperature-control module.

Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL.

Nascent RNA transcripts facilitate the formation of G-quadruplexes.

Single-molecule mechanochemical sensing using DNA origami nanostructures.

Intermediates stabilized by tryptophan pairs exist in trpzip Beta-hairpins.

Quantification of topological coupling between DNA superhelicity and G-quadruplex formation.

Direct quantification of loop interaction and π-π stacking for G-quadruplex stability at the submolecular level.

Dual binding of an antibody and a small molecule increases the stability of TERRA G-quadruplex.

Interaction of G-quadruplexes in the full-length 3' human telomeric overhang.

Dissecting cooperative communications in a protein with a high-throughput single-molecule scalpel.

Divalent cations and molecular crowding buffers stabilize G-triplex at physiologically relevant temperatures.

Mechanochemical Sensing: A Biomimetic Sensing Strategy.

A molecular tuning fork in single-molecule mechanochemical sensing.

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex.

Exploded view of higher order G-quadruplex structures through click-chemistry assisted single-molecule mechanical unfolding.

Mutually Exclusive Formation of G-Quadruplex and i-Motif Is a General Phenomenon Governed by Steric Hindrance in Duplex DNA.

Mechanical properties of DNA origami nanoassemblies are determined by Holliday junction mechanophores.

Mechanochemical Sensing of Single and Few Hg(II) Ions Using Polyvalent Principles.

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters.

A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III.

Confined space facilitates G-quadruplex formation.

Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units.

Quantification of Chemical and Mechanical Effects on the Formation of the G-Quadruplex and i-Motif in Duplex DNA.

Single-Molecule Mechanochemical pH Sensing Revealing the Proximity Effect of Hydroniums Generated by an Alkaline Phosphatase.

A New Concentration Jump Strategy Reveals the Lifetime of i-Motif at Physiological pH without Force.

Mechanical Cooperativity in DNA Cruciform Structures.

Decreased water activity in nanoconfinement contributes to the folding of G-quadruplex and i-motif structures.

Binding of a Telomestatin Derivative Changes the Mechanical Anisotropy of a Human Telomeric G-Quadruplex.

Random Formation of G-Quadruplexes in the Full-Length Human Telomere Overhangs Leads to a Kinetic Folding Pattern with Targetable Vacant G-Tracts.

Submolecular dissection reveals strong and specific binding of polyamide-pyridostatin conjugates to human telomere interface.

Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures.

Single-Molecule Investigations of G-Quadruplex.

Single-Molecule Topochemical Analyses for Large-Scale Multiplexing Tasks.

Chaperone-Assisted Host-Guest Interactions Revealed by Single-Molecule Force Spectroscopy.

Duplex DNA Is Weakened in Nanoconfinement.

Detecting the Coronavirus (COVID-19).

A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials.

Ensemble Sensing Using Single-Molecule DNA Copolymers.

Cooperative Heteroligand Interaction with G-Quadruplexes Shows Evidence of Allosteric Binding.

Chemo-Mechanical Modulation of Cell Motions Using DNA Nanosprings.

Mechanochemical properties of DNA origami nanosprings revealed by force jumps in optical tweezers.

Mechanical unfolding of ensemble biomolecular structures by shear force.

DNA origami nano-mechanics.

Measurement of Single-Molecule Forces in Cholesterol and Cyclodextrin Host-Guest Complexes.

Correction: DNA origami nano-mechanics.

Direct Measurement of Intermolecular Mechanical Force for Nonspecific Interactions between Small Molecules.

Chirality transmission in macromolecular domains.

Dissection of nanoconfinement and proximity effects on the binding events in DNA origami nanocavity.

Small Molecules Modulate Liquid-to-Solid Transitions in Phase-Separated Tau Condensates.

Single-Molecule Mechanochemical Sensing.

Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex.

Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes.