Norbert Perrimon

Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis.

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.

Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling.

CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila.

Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein.

The promise and perils of Wnt signaling through beta-catenin.

Cellular processes associated with germ band retraction in Drosophila.

Molecular mechanisms of epithelial morphogenesis.

Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila.

Hedgehog signal transduction: recent findings.

Unconventional ways to travel.

Analysis of twenty-four Gal4 lines in Drosophila melanogaster.

Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila.

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

Sequential activation of signaling pathways during innate immune responses in Drosophila.

A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding.

The Jak/STAT pathway in model organisms: emerging roles in cell movement.

Roles of myosin phosphatase during Drosophila development.

Integrated activity of PDZ protein complexes regulates epithelial polarity.

The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila.

Tailoring the genome: the power of genetic approaches.

Retraction of the Drosophila germ band requires cell-matrix interaction.

The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila.

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis.

Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.

Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1.

neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions.

Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.

Developmental roles of heparan sulfate proteoglycans in Drosophila.

Apicobasal polarization: epithelial form and function.

A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway.

Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis.

Genome-wide RNAi analysis of growth and viability in Drosophila cells.

Wingless, hedgehog and heparan sulfate proteoglycans.

Temperature-sensitive control of protein activity by conditionally splicing inteins.

The roles of JAK/STAT signaling in Drosophila immune responses.

The PDGF/VEGF receptor controls blood cell survival in Drosophila.

Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development.

Genome-wide high-throughput screens in functional genomics.

Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila.

Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research.

The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors.

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.

High-throughput RNA interference screens in Drosophila tissue culture cells.

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition.

Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity.

Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing.

Functional genomic analysis of the Wnt-wingless signaling pathway.

Drosophila Wnt/Fz pathways.

Function of the ETS transcription factor Yan in border cell migration.

Genome-wide RNAi screen for host factors required for intracellular bacterial infection.

Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.

Super-size flies.

Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila.

Norbert Perrimon.

Heparan sulphate proteoglycans: the sweet side of development.

Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E.

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway.

Evidence that stem cells reside in the adult Drosophila midgut epithelium.

FlyRNAi: the Drosophila RNAi screening center database.

Functional genomics reveals genes involved in protein secretion and Golgi organization.

High-throughput RNAi screening in cultured cells: a user's guide.

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo.

High-throughput approaches to dissecting MAPK signaling pathways.

The emergence of geometric order in proliferating metazoan epithelia.

Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays.

Minimizing the risk of reporting false positives in large-scale RNAi screens.

GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo.

COPI activity coupled with fatty acid biosynthesis is required for viral replication.

A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.

Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.

Applications of high-throughput RNA interference screens to problems in cell and developmental biology.

Genetic screening for signal transduction in the era of network biology.

Do-it-yourself RNAi made easy?

A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.

Quantitative morphological signatures define local signaling networks regulating cell morphology.

Design and implementation of high-throughput RNAi screens in cultured Drosophila cells.

A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila.

Functional screening identifies miR-315 as a potent activator of Wingless signaling.

Drosophila and the genetics of the internal milieu.

SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth.

In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography.

Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster.

Cellular phenotype recognition for high-content RNA interference genome-wide screening.

ESCRT factors restrict mycobacterial growth.

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes.

RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance.

An endogenous small interfering RNA pathway in Drosophila.

Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens.

An image score inference system for RNAi genome-wide screening based on fuzzy mixture regression modeling.

Identification of neural outgrowth genes using genome-wide RNAi.

Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning.

Developmental biology: Our fly cousins' gut.

Matter arising: off-targets and genome-scale RNAi screens in Drosophila.

Phosphorylation networks regulating JNK activity in diverse genetic backgrounds.

Comparative analysis of argonaute-dependent small RNA pathways in Drosophila.

Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila.

Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.

A Drosophila resource of transgenic RNAi lines for neurogenetics.

RNAiCut: automated detection of significant genes from functional genomic screens.

Droplet microfluidic technology for single-cell high-throughput screening.

The twin spot generator for differential Drosophila lineage analysis.

Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.

Cross-species RNAi rescue platform in Drosophila melanogaster.

Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening.

Homeostasis in infected epithelia: stem cells take the lead.

Hierarchical rules for Argonaute loading in Drosophila.

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia.

Use of a label-free quantitative platform based on MS/MS average TIC to calculate dynamics of protein complexes in insulin signaling.

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.

Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen.

Genomic screening with RNAi: results and challenges.

Realizing the promise of RNAi high throughput screening.

In vivo RNAi: today and tomorrow.

Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.

Steroids make you bigger? Fat chance says Myc.

A genome-wide gene function prediction resource for Drosophila melanogaster.

Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs.

作为一种模型系统研究自噬的果蝇。

Identification of adult midgut precursors in Drosophila.

Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis.

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration.

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.

Sarcomere formation occurs by the assembly of multiple latent protein complexes.

All for one, and one for all: the clonality of the intestinal stem cell niche.

The transcriptional diversity of 25 Drosophila cell lines.

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.

Identification of functional elements and regulatory circuits by Drosophila modENCODE.

The developmental transcriptome of Drosophila melanogaster.

Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila.

A genome-wide RNAi screen identifies core components of the Gâ‚‚-M DNA damage checkpoint.

False negative rates in Drosophila cell-based RNAi screens: a case study.

Intelligent Interfaces for Mining Large-Scale RNAi-HCS Image Databases.

Control of the mitotic cleavage plane by local epithelial topology.

Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.

A genome-scale shRNA resource for transgenic RNAi in Drosophila.

Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs.

Drosophila as a model for interorgan communication: lessons from studies on energy homeostasis.

An integrative approach to ortholog prediction for disease-focused and other functional studies.

Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.

RNAi screening: new approaches, understandings, and organisms.

Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling.

FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update.

The era of systems developmental biology.

Stringent Analysis of Gene Function and Protein-Protein Interactions Using Fluorescently Tagged Genes.