Xander H.T. Wehrens

Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin.

Angiogenesis-independent cardioprotection in FGF-1 transgenic mice.

Novel insights in the congenital long QT syndrome.

K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation.

A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating.

Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia.

Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.

Altered function and regulation of cardiac ryanodine receptors in cardiac disease.

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

Fetal cardiovascular response to large placental chorioangiomas.

Molecular determinants of altered contractility in heart failure.

Cardiac rupture complicating myocardial infarction.

Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak.

Cardiac ryanodine receptor function and regulation in heart disease.

Novel therapeutic approaches for heart failure by normalizing calcium cycling.

Calstabin deficiency, ryanodine receptors, and sudden cardiac death.

Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations.

Intracellular calcium release and cardiac disease.

Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.

Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure.

Ryanodine receptor-targeted anti-arrhythmic therapy.

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

Subcellular targeting of phosphatases: a novel function of ankyrins.

Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias.

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.

The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms?

Ryanodine receptors as pharmacological targets for heart disease.

Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.

Mutation-specific effects of lidocaine in Brugada syndrome.

Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions.

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

Alternative splicing: a key mechanism for ankyrin-B functional diversity?

Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation.

Calmodulin kinase II is required for fight or flight sinoatrial node physiology.

Molecular evolution of the junctophilin gene family.

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

Animal models of arrhythmogenic cardiomyopathy.

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.

Sudden infant death syndrome in mice with an inherited mutation in RyR2.

Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.

Stress synchronizes calcium release and promotes SR calcium leak.

Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification.

Digoxin treatment in heart failure - unveiling risk by cluster analysis of DIG data.

Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.

Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation.

Emerging role of junctophilin-2 as a regulator of calcium handling in the heart.

CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release.

The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications.

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.

Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.

Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.

Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship.

Targeting ryanodine receptors for anti-arrhythmic therapy.

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation.

Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.

Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform.

Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice.

Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome.