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Universitat Politècnica de Catalunya

3 ARTICLES PUBLISHED IN JoVE

JoVE Core

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Aida Llucià-Valldeperas^1,2, Ramon Bragós³, Antoni Bayés-Genís^1,4,5,6

¹Insuficiencia Cardiaca y Regeneración Cardiaca (ICREC) Research Program, Health Science Research Institute Germans Trias i Pujol, ²Amsterdam Universitair Medisch Centrum (UMC), Vrije Universiteit Amsterdam, Pulmonology and Physiology, Amsterdam Cardiovascular Sciences, ³Electronic and Biomedical Instrumentation Group, Departament d'Enginyeria Electrònica, Universitat Politècnica de Catalunya, ⁴Cardiology Service, Germans Trias i Pujol University Hospital, ⁵Department of Medicine, Universitat Autònoma de Barcelona, ⁶Centro de Investigación Biomédica en Red (CIBER) Cardiovascular, Instituto de Salud Carlos III

Here we present a protocol for training a cell population using electrical and mechanical stimuli emulating cardiac physiology. This electromechanical stimulation enhances the cardiomyogenic potential of the treated cells and is a promising strategy for further cell therapy, disease modeling, and drug screening.

Neuroscience

Quantified Assessment of Infant's Gross Motor Abilities Using a Multisensor Wearable

Elisa Taylor¹, Manu Airaksinen¹, Anastasia Gallen¹, Tuuli Immonen², Elina Ilén³, Taru Palsa^1,2, Leena M. Haataja^1,2, Sampsa Vanhatalo^1,4

¹BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki, University Hospital, ²Department of Pediatric Neurology, Children's Hospital, Helsinki University Hospital and University of Helsinki, ³Department of Materials Science and Engineering, Universitat Politècnica de Catalunya, ⁴Department of Physiology, University of Helsinki

This paper outlines the assessment of infants' gross motor performance with a multisensor wearable and its fully automated deep learning-based analysis pipeline. The method quantifies the posture and movement patterns of infants from lying supine until they master walking independently.

Medicine

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

David Alfaiate^1,2, Carlos Mas-Moruno^3,4, Cidália Manuela⁵, Josep Maria Ustrell^6,7, Juan Antonio Camara^8,9, Marina Ferrer^10,11, José Maria Manero^3,4, Maria-Cristina Manzanares-Céspedes¹²

¹Faculty of Medicine and Health Sciences, University of Barcelona, ²Department of Oral Surgery, Davallmed Clinic. Porto, ³Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya, ⁴Barcelona Research Centre in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, ⁵Department of Periodontology, Davallmed Clinic. Porto, ⁶Department of Odontostomatology, University of Barcelona, ⁷Oral Health and Masticatory System Research Group at the Bellvitge Biomedical Research Institute (IDIBELL), ⁸Preclinical imaging platform, Vall d'Hebron Research Institute, Barcelona, ⁹Preclinical Therapeutics Core, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, ¹⁰Animal facility, Vall d'Hebron Research Institute, Barcelona, ¹¹UCSF Gnotobiotics Core Facility, University of California, San Francisco, ¹²Human Anatomy and Embryology Unit, Experimental Pathology and Therapeutics Department, Faculty of Medicine and Health Sciences, University of Barcelona

The placement of implants in a rat model is an essential experimental procedure for clinical research. This study presents a comprehensive surgical protocol for implanting titanium implants into the tibia of rat models with diabetes and osteoporosis.