Universidad Nacional Autónoma de Mexico (UNAM)

2 ARTICLES PUBLISHED IN JoVE

Medicine

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Benjamín León-Mancilla^1,2, Moisés Martínez-Castillo¹, Zaira Medina-Avila¹, Armando Pérez-Torres³, Jorge Garcia-Loya², Ana Alfaro-Cruz⁴, Cristina Piña-Barba⁵, Gabriela Gutierrez-Reyes¹

¹Liver, Pancreas and Motility Laboratory; Unit of Experimental Medicine; School of Medicine, Universidad Nacional Autónoma de Mexico (UNAM), ²Department of Surgery, School of Medicine, Universidad Nacional Autónoma de México (UNAM), ³Department of Cells and Tissue Biology, School of Medicine, Universidad Nacional Autónoma de México (UNAM), ⁴Department of Pathology, Hospital General de Mexico, ⁵Materials Research Institute, Universidad Nacional Autónoma de México (UNAM)

Liver diseases are induced by many causes that promote fibrosis or cirrhosis. Transplantation is the only option for recovering health. However, given the scarcity of transplantable organs, alternatives must be explored. Our research proposes the implantation of collagen scaffolds in liver tissue from an animal model.

Immunology and Infection

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Betsaida J. Ortiz-Sánchez^1,2, Imelda Juárez Avelar^2,3, Miriam Rodriguez-Sosa²

¹Undergraduate Program of Dental Surgeon, Facultad de Estudios Superiores Iztacala (FES-Iztacala), Universidad Nacional Autónoma de Mexico (UNAM), ²Innate Immunity Laboratory, Biomedicine Research Unit (UBIMED), FES-Iztacala, UNAM, ³Doctoral Program in Biological Sciences, UNAM

This study describes a modified 6-0 nylon ligation method for inducing periodontitis in mice, which is highly reproducible and represents an alternative for researchers to study periodontal disease from its development to its pathological consequences.