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DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance

2 ARTICLES PUBLISHED IN JoVE

Medicine

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Maximilian Grab^1,2, Carina Hopfner³, Alena Gesenhues⁴, Fabian König^1,2, Nikolaus A. Haas³, Christian Hagl¹, Adrian Curta⁴, Nikolaus Thierfelder¹

¹Department of Cardiac Surgery, Ludwig Maximilian University Munich, ²Chair of Medical Materials and Implants, Technical University of Munich, ³Department Pediatric Cardiology and Pediatric Intensive Care, Ludwig Maximilian University Munich, ⁴Department of Radiology, Ludwig Maximilian University Munich

Here we present development of a mock circulation setup for multimodal therapy evaluation, pre-interventional planning, and physician-training on cardiovascular anatomies. With the application of patient-specific tomographic scans, this setup is ideal for therapeutic approaches, training, and education in individualized medicine.

Medicine

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

Benedikt Freystetter¹, Maximilian Grab^1,2, Linda Grefen¹, Lara Bischof¹, Lorenz Isert³, Petra Mela², Deon Bezuidenhout⁴, Christian Hagl^1,5, Nikolaus Thierfelder¹

¹Department of Cardiac Surgery, Ludwig Maximilians University Munich, ²Chair of Medical Materials and Implants, Technical University Munich, ³Faculty for Chemistry and Pharmacy, Ludwig Maximilians University Munich, ⁴Cardiovascular Research Unit, University of Cape Town, ⁵DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance

The presented method offers an innovative way for engineering biomimetic fiber structures in three-dimensional (3D) scaffolds (e.g., heart valve leaflets). 3D-printed, conductive geometries were used to determine shape and dimensions. Fiber orientation and characteristics were individually adjustable for each layer. Multiple samples could be manufactured in one setup.