Monica Driscoll

Neuropathology of degenerative cell death in Caenorhabditis elegans.

UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans.

Caloric restriction and lifespan: a role for protein turnover?

Protons at the gate: DEG/ENaC ion channels help us feel and remember.

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.

A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans.

Dying for a cause: invertebrate genetics takes on human neurodegeneration.

Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans.

In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation.

The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation.

In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans.

Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance.

Modulated microRNA expression during adult lifespan in Caenorhabditis elegans.

Caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse.

Culture of embryonic C. elegans cells for electrophysiological and pharmacological analyses.

Heterologous expression of C. elegans ion channels in Xenopus oocytes.

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.

A novel computational approach for simultaneous tracking and feature extraction of C. elegans populations in fluid environments.

Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology.

A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans.

Caenorhabditis elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity.

FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.

MicroRNAs in C. elegans Aging: Molecular Insurance for Robustness?

Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.

Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-gamma, and IP3R activation.

Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.

Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.

EGF signaling comes of age: promotion of healthy aging in C. elegans.

The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans.

Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.

Complex expression dynamics and robustness in C. elegans insulin networks.

Dramatic fertility decline in aging C. elegans males is associated with mating execution deficits rather than diminished sperm quality.

Deletion of microRNA-80 activates dietary restriction to extend C. elegans healthspan and lifespan.

Neuronal repair: Apoptotic proteins make good.

NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels.

A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.

Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves.

CeleST: computer vision software for quantitative analysis of C. elegans swim behavior reveals novel features of locomotion.

Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons.

Flow-scanning optical tomography.

A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells.

Using measures of single-cell physiology and physiological state to understand organismic aging.

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons.

Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.

A long journey to reproducible results.

TOR-mediated regulation of metabolism in aging.

Q&A: Trash talk: disposal and remote degradation of neuronal garbage.

NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans.

Necrotic Neurodegeneration in Caenorhabditis Elegans.

Execution of Necrotic-Like Cell Death in Requires Cathepsin D Activity.

CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis.

Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions.

Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes.

Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.

Healthy lifespan extension mediated by oenothein B isolated from Eucalyptus grandis × Eucalyptus urophylla GL9 in Caenorhabditis elegans.

Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes.

Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension.