Department of Molecular Biology and Biochemistry
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Neuropathology of degenerative cell death in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 1997 | Pubmed ID: 8994058
UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans.
Genes & development Nov, 1999 | Pubmed ID: 10557206
Caloric restriction and lifespan: a role for protein turnover?
Mechanisms of ageing and development Jan, 2002 | Pubmed ID: 11718814
Protons at the gate: DEG/ENaC ion channels help us feel and remember.
Neuron Apr, 2002 | Pubmed ID: 11988165
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.
Nature Oct, 2002 | Pubmed ID: 12397350
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.
Nature Oct, 2002 | Pubmed ID: 12410314
A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans.
The Journal of biological chemistry Apr, 2003 | Pubmed ID: 12533541
Dying for a cause: invertebrate genetics takes on human neurodegeneration.
Nature reviews. Genetics Mar, 2003 | Pubmed ID: 12610523
Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans.
Journal of cell science May, 2003 | Pubmed ID: 12665560
In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation.
Neuron Sep, 2003 | Pubmed ID: 12971899
The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation.
Nature neuroscience Dec, 2004 | Pubmed ID: 15543143
In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans.
Aging cell Jun, 2005 | Pubmed ID: 15924569
Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance.
The Journal of biological chemistry Dec, 2005 | Pubmed ID: 16239217
Modulated microRNA expression during adult lifespan in Caenorhabditis elegans.
Aging cell Jun, 2006 | Pubmed ID: 16842496
Caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse.
The Journal of biological chemistry Nov, 2007 | Pubmed ID: 17681948
Culture of embryonic C. elegans cells for electrophysiological and pharmacological analyses.
WormBook : the online review of C. elegans biology , 2006 | Pubmed ID: 18050435
Heterologous expression of C. elegans ion channels in Xenopus oocytes.
WormBook : the online review of C. elegans biology , 2006 | Pubmed ID: 18050441
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
PLoS genetics Feb, 2008 | Pubmed ID: 18282106
A novel computational approach for simultaneous tracking and feature extraction of C. elegans populations in fluid environments.
IEEE transactions on bio-medical engineering May, 2008 | Pubmed ID: 18440900
Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology.
PloS one Jul, 2008 | Pubmed ID: 18665242
A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans.
The EMBO journal Sep, 2008 | Pubmed ID: 18701922
Caenorhabditis elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity.
Journal of neurochemistry Mar, 2009 | Pubmed ID: 19054279
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2009 | Pubmed ID: 19553463
MicroRNAs in C. elegans Aging: Molecular Insurance for Robustness?
Current genomics May, 2009 | Pubmed ID: 19881908
Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.
PloS one Jan, 2010 | Pubmed ID: 20090912
Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-gamma, and IP3R activation.
Aging cell Aug, 2010 | Pubmed ID: 20497132
Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.
Nature neuroscience Jul, 2010 | Pubmed ID: 20512132
Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.
Journal of neurophysiology Dec, 2010 | Pubmed ID: 20881202
EGF signaling comes of age: promotion of healthy aging in C. elegans.
Experimental gerontology Feb-Mar, 2011 | Pubmed ID: 21074601
The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans.
PLoS biology , 2012 | Pubmed ID: 22629231
Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2012 | Pubmed ID: 22745480
Complex expression dynamics and robustness in C. elegans insulin networks.
Genome research Jun, 2013 | Pubmed ID: 23539137
Dramatic fertility decline in aging C. elegans males is associated with mating execution deficits rather than diminished sperm quality.
Experimental gerontology Nov, 2013 | Pubmed ID: 23916839
Deletion of microRNA-80 activates dietary restriction to extend C. elegans healthspan and lifespan.
PLoS genetics Aug, 2013 | Pubmed ID: 24009527
Neuronal repair: Apoptotic proteins make good.
Worm Apr, 2013 | Pubmed ID: 24058867
NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels.
The Journal of biological chemistry Apr, 2014 | Pubmed ID: 24567339
A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.
The Journal of biological chemistry Apr, 2014 | Pubmed ID: 24644293
Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves.
Journal of agricultural and food chemistry Apr, 2014 | Pubmed ID: 24701969
CeleST: computer vision software for quantitative analysis of C. elegans swim behavior reveals novel features of locomotion.
PLoS computational biology Jul, 2014 | Pubmed ID: 25033081
Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons.
Frontiers in genetics , 2014 | Pubmed ID: 25101108
Flow-scanning optical tomography.
Lab on a chip Dec, 2014 | Pubmed ID: 25256716
A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells.
Nature communications Jan, 2015 | Pubmed ID: 25564762
Using measures of single-cell physiology and physiological state to understand organismic aging.
Aging cell Feb, 2016 | Pubmed ID: 26616110
Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2016 | Pubmed ID: 26818523
Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.
NPJ aging and mechanisms of disease , 2016 | Pubmed ID: 27347427
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
Nature communications Feb, 2017 | Pubmed ID: 28220799
A long journey to reproducible results.
Nature 08, 2017 | Pubmed ID: 28836615
TOR-mediated regulation of metabolism in aging.
Aging cell 12, 2017 | Pubmed ID: 28971552
Q&A: Trash talk: disposal and remote degradation of neuronal garbage.
BMC biology 01, 2018 | Pubmed ID: 29382333
NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans.
Lab on a chip 07, 2018 | Pubmed ID: 29892747
Necrotic Neurodegeneration in Caenorhabditis Elegans.
TheScientificWorldJournal , 2001 | Pubmed ID: 30147608
Execution of Necrotic-Like Cell Death in Requires Cathepsin D Activity.
TheScientificWorldJournal , 2001 | Pubmed ID: 30147617
CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis.
Scientific reports 09, 2019 | Pubmed ID: 31527664
Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions.
GeroScience 12, 2019 | Pubmed ID: 31820364
Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes.
microPublication biology , 2020 | Pubmed ID: 31998863
Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.
microPublication biology , 2019 | Pubmed ID: 32010883
Healthy lifespan extension mediated by oenothein B isolated from Eucalyptus grandis × Eucalyptus urophylla GL9 in Caenorhabditis elegans.
Food & function Mar, 2020 | Pubmed ID: 32129349
Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes.
microPublication biology May, 2020 | Pubmed ID: 32550518
Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension.
PLoS genetics 08, 2020 | Pubmed ID: 32841230
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