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Centre for Misfolding Diseases,
Department of Chemistry,
Centre for Misfolding Diseases, Department of Chemistry
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An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.
Science advances Feb, 2016 | Pubmed ID: 26933687
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 01, 2017 | Pubmed ID: 28011763
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Proceedings of the National Academy of Sciences of the United States of America 02, 2017 | Pubmed ID: 28096355
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.
Science advances Jun, 2017 | Pubmed ID: 28691099
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.
Scientific reports Nov, 2017 | Pubmed ID: 29118344
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.
Science (New York, N.Y.) 12, 2017 | Pubmed ID: 29242346
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
Journal of neuroscience methods Aug, 2018 | Pubmed ID: 29452179
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
ACS chemical biology Aug, 2018 | Pubmed ID: 29953201
Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.
ACS chemical neuroscience Aug, 2018 | Pubmed ID: 29986583
University of Cambridge
Michele Perni1,
Sam Casford1,
Francesco A. Aprile1,
Ellen A. Nollen2,
Tuomas P.J. Knowles1,
Michele Vendruscolo1,
Christopher M. Dobson1
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge,
2European Research Institute for the Biology of Aging, University Medical Centre Groningen
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