Centre for Misfolding Diseases,
Department of Chemistry,
Centre for Misfolding Diseases, Department of Chemistry
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Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain.
Protein science : a publication of the Protein Society Dec, 2001 | Pubmed ID: 11714922
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12374855
The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation.
The EMBO journal Nov, 2002 | Pubmed ID: 12411486
Altered aggregation properties of mutant gamma-crystallins cause inherited cataract.
The EMBO journal Nov, 2002 | Pubmed ID: 12426373
De novo designed peptide-based amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12456886
Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12481032
Calculation of mutational free energy changes in transition states for protein folding.
Biophysical journal Aug, 2003 | Pubmed ID: 12885664
Chemical modification of insulin in amyloid fibrils.
Protein science : a publication of the Protein Society Nov, 2003 | Pubmed ID: 14573875
The circularization of amyloid fibrils formed by apolipoprotein C-II.
Biophysical journal Dec, 2003 | Pubmed ID: 14645087
Structures and relative free energies of partially folded states of proteins.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2003 | Pubmed ID: 14657374
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2004 | Pubmed ID: 14715898
Exploring amyloid formation by a de novo design.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2004 | Pubmed ID: 15070736
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.
Proceedings of the National Academy of Sciences of the United States of America May, 2004 | Pubmed ID: 15123800
Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2004 | Pubmed ID: 15263071
The formation of spherulites by amyloid fibrils of bovine insulin.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2004 | Pubmed ID: 15381766
A glimpse at the organization of the protein universe.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2005 | Pubmed ID: 15827120
Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2005 | Pubmed ID: 15956205
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2005 | Pubmed ID: 16006528
Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2005 | Pubmed ID: 16116084
Amyloid fibril formation can proceed from different conformations of a partially unfolded protein.
Biophysical journal Dec, 2005 | Pubmed ID: 16169975
Characterization of the nanoscale properties of individual amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2006 | Pubmed ID: 17038504
Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides.
Protein science : a publication of the Protein Society Jun, 2007 | Pubmed ID: 17525469
Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2007 | Pubmed ID: 17540728
Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2007 | Pubmed ID: 17940046
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils.
PLoS computational biology Sep, 2007 | Pubmed ID: 17941703
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.
PLoS biology Oct, 2007 | Pubmed ID: 17973577
Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.
Protein science : a publication of the Protein Society May, 2008 | Pubmed ID: 18436957
A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction.
Structure (London, England : 1993) May, 2008 | Pubmed ID: 18462678
Immunological features of alpha-synuclein in Parkinson's disease.
Journal of cellular and molecular medicine Oct, 2008 | Pubmed ID: 18671754
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18796612
Recombinant amyloid beta-peptide production by coexpression with an affibody ligand.
BMC biotechnology Oct, 2008 | Pubmed ID: 18973685
A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates.
PLoS computational biology Nov, 2008 | Pubmed ID: 19008938
Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation.
Proceedings of the National Academy of Sciences of the United States of America May, 2009 | Pubmed ID: 19416886
Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate.
PloS one , 2009 | Pubmed ID: 19440546
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy.
Journal of molecular biology Jul, 2009 | Pubmed ID: 19481095
Long-range correlations between aliphatic 13C nuclei in protein MAS NMR spectroscopy.
Angewandte Chemie (International ed. in English) , 2009 | Pubmed ID: 19562810
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.
The EMBO journal Dec, 2009 | Pubmed ID: 19875982
Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations.
Biophysical journal Nov, 2009 | Pubmed ID: 19883594
Folding study of Venus reveals a strong ion dependence of its yellow fluorescence under mildly acidic conditions.
The Journal of biological chemistry Feb, 2010 | Pubmed ID: 19901033
Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2009 | Pubmed ID: 20018739
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.
Biochemistry Feb, 2010 | Pubmed ID: 20041693
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation.
Biophysical journal Mar, 2010 | Pubmed ID: 20197038
Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.
PLoS biology Mar, 2010 | Pubmed ID: 20305716
A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.
Protein engineering, design & selection : PEDS Jul, 2010 | Pubmed ID: 20382744
Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide.
Biophysical journal Apr, 2010 | Pubmed ID: 20409489
Physicochemical determinants of chaperone requirements.
Journal of molecular biology Jul, 2010 | Pubmed ID: 20416322
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.
Journal of molecular biology Sep, 2010 | Pubmed ID: 20620148
The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity.
Journal of molecular biology Oct, 2010 | Pubmed ID: 20624399
Surface attachment of protein fibrils via covalent modification strategies.
The journal of physical chemistry. B Sep, 2010 | Pubmed ID: 20695458
High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure .
Biochemistry Sep, 2010 | Pubmed ID: 20707313
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20713699
Frequency factors in a landscape model of filamentous protein aggregation.
Physical review letters Jun, 2010 | Pubmed ID: 20873942
Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution.
Journal of the American Chemical Society Nov, 2010 | Pubmed ID: 20958028
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.
PloS one Oct, 2010 | Pubmed ID: 21048992
Transient tertiary structure formation within the ribosome exit port.
Journal of the American Chemical Society Dec, 2010 | Pubmed ID: 21062068
Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors.
Biophysical journal Nov, 2010 | Pubmed ID: 21081099
New scenarios of protein folding can occur on the ribosome.
Journal of the American Chemical Society Jan, 2011 | Pubmed ID: 21204555
Relationship between prion propensity and the rates of individual molecular steps of fibril assembly.
The Journal of biological chemistry Apr, 2011 | Pubmed ID: 21233211
Protein dynamics: Moore's law in molecular biology.
Current biology : CB Jan, 2011 | Pubmed ID: 21256436
A FRET sensor for non-invasive imaging of amyloid formation in vivo.
Chemphyschem : a European journal of chemical physics and physical chemistry Feb, 2011 | Pubmed ID: 21308945
Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease.
Journal of neuroscience methods Apr, 2011 | Pubmed ID: 21315762
Population of nonnative states of lysozyme variants drives amyloid fibril formation.
Journal of the American Chemical Society May, 2011 | Pubmed ID: 21528861
Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions.
Biophysical journal Jun, 2011 | Pubmed ID: 21641324
¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase.
Biomolecular NMR assignments Apr, 2012 | Pubmed ID: 21643968
Metastability of native proteins and the phenomenon of amyloid formation.
Journal of the American Chemical Society Sep, 2011 | Pubmed ID: 21650202
Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein.
Angewandte Chemie (International ed. in English) Jul, 2011 | Pubmed ID: 21671315
Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein.
Journal of molecular biology Aug, 2011 | Pubmed ID: 21689664
The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster.
Integrative biology : quantitative biosciences from nano to macro Jul, 2011 | Pubmed ID: 21698336
Probing protein aggregation with quartz crystal microbalances.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21713635
Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR.
Journal of the American Chemical Society Sep, 2011 | Pubmed ID: 21774549
In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging.
Journal of the American Chemical Society Aug, 2011 | Pubmed ID: 21793568
Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.
PloS one , 2011 | Pubmed ID: 21818368
Protein solubility and protein homeostasis: a generic view of protein misfolding disorders.
Cold Spring Harbor perspectives in biology Dec, 2011 | Pubmed ID: 21825020
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments.
The Journal of chemical physics Aug, 2011 | Pubmed ID: 21842954
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations.
The Journal of chemical physics Aug, 2011 | Pubmed ID: 21842955
Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.
The Journal of chemical physics Aug, 2011 | Pubmed ID: 21842956
Observation of spatial propagation of amyloid assembly from single nuclei.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2011 | Pubmed ID: 21876182
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation.
Biophysical journal Oct, 2011 | Pubmed ID: 21961594
Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan, 2012 | Pubmed ID: 21965601
Probing small molecule binding to amyloid fibrils.
Physical chemistry chemical physics : PCCP Dec, 2011 | Pubmed ID: 22006124
Nucleated polymerisation in the presence of pre-formed seed filaments.
International journal of molecular sciences , 2011 | Pubmed ID: 22016630
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.
PLoS computational biology Oct, 2011 | Pubmed ID: 22022239
Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22160682
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.
Nature structural & molecular biology Dec, 2011 | Pubmed ID: 22179788
The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila.
PloS one , 2012 | Pubmed ID: 22384095
From macroscopic measurements to microscopic mechanisms of protein aggregation.
Journal of molecular biology Aug, 2012 | Pubmed ID: 22406275
Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity.
The Journal of biological chemistry Jun, 2012 | Pubmed ID: 22461632
Detailed analysis of the energy barriers for amyloid fibril growth.
Angewandte Chemie (International ed. in English) May, 2012 | Pubmed ID: 22489083
Intrinsic disorder modulates protein self-assembly and aggregation.
Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22509003
Measuring the kinetics of amyloid fibril elongation using quartz crystal microbalances.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22528086
Direct observation of the interconversion of normal and toxic forms of α-synuclein.
Cell May, 2012 | Pubmed ID: 22632969
Prediction of variable translation rate effects on cotranslational protein folding.
Nature communications May, 2012 | Pubmed ID: 22643895
Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions.
Journal of the American Chemical Society Jul, 2012 | Pubmed ID: 22680285
Characterizing intermolecular interactions that initiate native-like protein aggregation.
Biophysical journal Jun, 2012 | Pubmed ID: 22713575
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2012 | Pubmed ID: 22802614
Role of elongation and secondary pathways in S6 amyloid fibril growth.
Biophysical journal May, 2012 | Pubmed ID: 22824281
Nanobodies as structural probes of protein misfolding and fibril formation.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22886275
Twisting transition between crystalline and fibrillar phases of aggregated peptides.
Physical review letters Oct, 2012 | Pubmed ID: 23102370
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones.
Biochemistry Nov, 2012 | Pubmed ID: 23106396
Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.
PloS one , 2012 | Pubmed ID: 23166837
In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2013 | Pubmed ID: 23256155
Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells.
Journal of the American Chemical Society Jan, 2013 | Pubmed ID: 23339742
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms.
FEBS letters Mar, 2013 | Pubmed ID: 23353684
Protein amyloids develop an intrinsic fluorescence signature during aggregation.
The Analyst Apr, 2013 | Pubmed ID: 23420088
Electrostatic effects in filamentous protein aggregation.
Biophysical journal Mar, 2013 | Pubmed ID: 23473495
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23513222
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences May, 2013 | Pubmed ID: 23530260
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
Journal of molecular biology Jul, 2013 | Pubmed ID: 23557833
A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence.
Chembiochem : a European journal of chemical biology May, 2013 | Pubmed ID: 23592254
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2013 | Pubmed ID: 23703910
α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling.
The Journal of biological chemistry Jul, 2013 | Pubmed ID: 23740253
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.
PloS one , 2013 | Pubmed ID: 23840795
Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide.
The Journal of chemical physics Jul, 2013 | Pubmed ID: 23883055
A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
The journal of physical chemistry. B Oct, 2013 | Pubmed ID: 23919586
Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations.
Biochemistry Sep, 2013 | Pubmed ID: 23941501
In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells.
PloS one , 2013 | Pubmed ID: 23991082
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.
Cell reports Nov, 2013 | Pubmed ID: 24183671
Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide.
ACS chemical biology Feb, 2014 | Pubmed ID: 24199868
Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.
PloS one , 2013 | Pubmed ID: 24236103
Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy.
Nano letters Jan, 2014 | Pubmed ID: 24303845
Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy.
Journal of the American Chemical Society Dec, 2013 | Pubmed ID: 24304221
A clear view of polymorphism, twist, and chirality in amyloid fibril formation.
ACS nano Dec, 2013 | Pubmed ID: 24359171
Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates.
Nature communications , 2014 | Pubmed ID: 24394622
A simple lattice model that captures protein folding, aggregation and amyloid formation.
PloS one , 2014 | Pubmed ID: 24454816
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.
PloS one , 2014 | Pubmed ID: 24551051
Chemical kinetics for drug discovery to combat protein aggregation diseases.
Trends in pharmacological sciences Mar, 2014 | Pubmed ID: 24560688
Dynamics and timekeeping in biological systems.
Annual review of biochemistry , 2014 | Pubmed ID: 24606145
Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage.
Biochemistry Apr, 2014 | Pubmed ID: 24717093
Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.
Acta neuropathologica communications Apr, 2014 | Pubmed ID: 24725347
Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters.
Physical review. E, Statistical, nonlinear, and soft matter physics Mar, 2014 | Pubmed ID: 24730879
Understanding the influence of codon translation rates on cotranslational protein folding.
Accounts of chemical research May, 2014 | Pubmed ID: 24784899
Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin.
Proceedings of the National Academy of Sciences of the United States of America May, 2014 | Pubmed ID: 24799681
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation.
Proceedings of the National Academy of Sciences of the United States of America May, 2014 | Pubmed ID: 24817693
The amyloid state and its association with protein misfolding diseases.
Nature reviews. Molecular cell biology Jun, 2014 | Pubmed ID: 24854788
Direct observations of amyloid β self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation.
Chemistry & biology Jun, 2014 | Pubmed ID: 24856820
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour.
Nature communications May, 2014 | Pubmed ID: 24871041
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2014 | Pubmed ID: 24938782
The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation.
Essays in biochemistry , 2014 | Pubmed ID: 25131584
Antibodies and protein misfolding: From structural research tools to therapeutic strategies.
Biochimica et biophysica acta Nov, 2014 | Pubmed ID: 25194824
Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.
The Journal of biological chemistry Nov, 2014 | Pubmed ID: 25217638
Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).
Chembiochem : a European journal of chemical biology Nov, 2014 | Pubmed ID: 25294384
A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein.
Biochemistry Nov, 2014 | Pubmed ID: 25389903
Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.
Nature communications Nov, 2014 | Pubmed ID: 25391268
Protein microgels from amyloid fibril networks.
ACS nano Jan, 2015 | Pubmed ID: 25469621
Structure of a low-population intermediate state in the release of an enzyme product.
eLife Jan, 2015 | Pubmed ID: 25575179
Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases.
Trends in pharmacological sciences Feb, 2015 | Pubmed ID: 25636813
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.
Nature chemical biology Mar, 2015 | Pubmed ID: 25643172
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
Nature structural & molecular biology Mar, 2015 | Pubmed ID: 25686087
Investigating the mechanisms of amylolysis of starch granules by solution-state NMR.
Biomacromolecules May, 2015 | Pubmed ID: 25815624
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2015 | Pubmed ID: 25855634
Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.
Journal of molecular biology Jun, 2015 | Pubmed ID: 25861763
Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype.
Immunity, inflammation and disease Dec, 2014 | Pubmed ID: 25866630
Widespread Proteome Remodeling and Aggregation in Aging C. elegans.
Cell May, 2015 | Pubmed ID: 25957690
The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution.
Colloids and surfaces. B, Biointerfaces Jul, 2015 | Pubmed ID: 25969417
Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry.
ACS nano Jun, 2015 | Pubmed ID: 26030507
Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity.
PloS one , 2015 | Pubmed ID: 26038823
Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies.
PloS one , 2015 | Pubmed ID: 26103636
Force generation by the growth of amyloid aggregates.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2015 | Pubmed ID: 26195762
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
Analytical chemistry Sep, 2015 | Pubmed ID: 26258431
Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates.
Chemical communications (Cambridge, England) Oct, 2015 | Pubmed ID: 26328629
Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity.
Nature chemistry Oct, 2015 | Pubmed ID: 26391079
Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide.
Biological & pharmaceutical bulletin , 2015 | Pubmed ID: 26424029
Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α-synuclein-elicited immune response.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2016 | Pubmed ID: 26443817
Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins.
Biochemistry Nov, 2015 | Pubmed ID: 26479087
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.
Current Alzheimer research , 2015 | Pubmed ID: 26510979
SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.
Molecular neurodegeneration Oct, 2015 | Pubmed ID: 26520394
The length distribution of frangible biofilaments.
The Journal of chemical physics Oct, 2015 | Pubmed ID: 26520548
Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide.
Biochemical and biophysical research communications Dec, 2015 | Pubmed ID: 26551456
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.
Antioxidants & redox signaling Mar, 2016 | Pubmed ID: 26564470
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
Scientific reports Nov, 2015 | Pubmed ID: 26582456
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.
ACS nano Jan, 2016 | Pubmed ID: 26678709
Molecular mechanisms of protein aggregation from global fitting of kinetic models.
Nature protocols Feb, 2016 | Pubmed ID: 26741409
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
ACS chemical neuroscience Mar, 2016 | Pubmed ID: 26800462
Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
Biophysical journal Feb, 2016 | Pubmed ID: 26840721
Hamiltonian Dynamics of Protein Filament Formation.
Physical review letters Jan, 2016 | Pubmed ID: 26849615
An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation.
The journal of physical chemistry. B Mar, 2016 | Pubmed ID: 26865546
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2016 | Pubmed ID: 26884195
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.
ACS combinatorial science Mar, 2016 | Pubmed ID: 26923286
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.
Nature structural & molecular biology Apr, 2016 | Pubmed ID: 26926436
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.
Science advances Feb, 2016 | Pubmed ID: 26933687
Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing.
Journal of the American Chemical Society Mar, 2016 | Pubmed ID: 26967463
Quantitative thermophoretic study of disease-related protein aggregates.
Scientific reports Mar, 2016 | Pubmed ID: 26984748
Ca2+ is a key factor in α-synuclein-induced neurotoxicity.
Journal of cell science 05, 2016 | Pubmed ID: 26989132
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2016 | Pubmed ID: 26993805
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.
Nature communications Mar, 2016 | Pubmed ID: 27009901
A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2016 | Pubmed ID: 27071083
Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor.
Proceedings of the National Academy of Sciences of the United States of America May, 2016 | Pubmed ID: 27092002
Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein.
Biochemistry 06, 2016 | Pubmed ID: 27096466
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.
Molecular cell Apr, 2016 | Pubmed ID: 27151442
Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity.
Scientific reports 06, 2016 | Pubmed ID: 27273030
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.
Proceedings of the National Academy of Sciences of the United States of America 06, 2016 | Pubmed ID: 27298346
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.
Scientific reports 06, 2016 | Pubmed ID: 27346247
Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform.
Journal of the American Chemical Society 08, 2016 | Pubmed ID: 27387359
Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies.
The Journal of biological chemistry 09, 2016 | Pubmed ID: 27445339
Towards a structural biology of the hydrophobic effect in protein folding.
Scientific reports 07, 2016 | Pubmed ID: 27461719
The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Human molecular genetics 09, 2016 | Pubmed ID: 27466192
Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation.
Chembiochem : a European journal of chemical biology 10, 2016 | Pubmed ID: 27472818
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.
Science advances 08, 2016 | Pubmed ID: 27532054
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
Proceedings of the National Academy of Sciences of the United States of America 09, 2016 | Pubmed ID: 27573854
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases.
Scientific reports 09, 2016 | Pubmed ID: 27619987
Structural basis of synaptic vesicle assembly promoted by α-synuclein.
Nature communications 09, 2016 | Pubmed ID: 27640673
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.
Scientific reports 11, 2016 | Pubmed ID: 27808107
Bifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ.
PloS one , 2016 | Pubmed ID: 27824888
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.
Biophysical journal Dec, 2016 | Pubmed ID: 27926837
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping.
Nature communications 12, 2016 | Pubmed ID: 27929085
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 01, 2017 | Pubmed ID: 28011763
The Amyloid Phenomenon and Its Links with Human Disease.
Cold Spring Harbor perspectives in biology Jun, 2017 | Pubmed ID: 28062560
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Proceedings of the National Academy of Sciences of the United States of America 02, 2017 | Pubmed ID: 28096355
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.
Biochemistry 03, 2017 | Pubmed ID: 28230968
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.
Proceedings of the National Academy of Sciences of the United States of America 05, 2017 | Pubmed ID: 28396410
Ultrasensitive Measurement of Ca Influx into Lipid Vesicles Induced by Protein Aggregates.
Angewandte Chemie (International ed. in English) Jun, 2017 | Pubmed ID: 28474754
Amyloid-like Fibrils from an α-Helical Transmembrane Protein.
Biochemistry 06, 2017 | Pubmed ID: 28493669
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.
Annual review of biochemistry 06, 2017 | Pubmed ID: 28498720
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.
Proceedings of the National Academy of Sciences of the United States of America 06, 2017 | Pubmed ID: 28584111
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 07, 2017 | Pubmed ID: 28652376
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
BMC biology 07, 2017 | Pubmed ID: 28673288
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.
Science advances Jun, 2017 | Pubmed ID: 28691099
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.
Proceedings of the National Academy of Sciences of the United States of America 07, 2017 | Pubmed ID: 28698377
The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.
Neurobiology of disease Jan, 2018 | Pubmed ID: 28709995
The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.
Biochimica et biophysica acta. Molecular basis of disease 11, 2017 | Pubmed ID: 28711596
Silk micrococoons for protein stabilisation and molecular encapsulation.
Nature communications 07, 2017 | Pubmed ID: 28722016
Sequential Release of Proteins from Structured Multishell Microcapsules.
Biomacromolecules Oct, 2017 | Pubmed ID: 28792742
Gradient-free determination of isoelectric points of proteins on chip.
Physical chemistry chemical physics : PCCP Aug, 2017 | Pubmed ID: 28817152
Absolute Quantification of Amyloid Propagons by Digital Microfluidics.
Analytical chemistry Nov, 2017 | Pubmed ID: 28972786
Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.
Chemical science Jun, 2017 | Pubmed ID: 28979758
Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.
Journal of the American Chemical Society 11, 2017 | Pubmed ID: 28994295
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.
Glia 01, 2018 | Pubmed ID: 29024008
Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.
Scientific reports Nov, 2017 | Pubmed ID: 29101328
Clusterin protects neurons against intracellular proteotoxicity.
Acta neuropathologica communications Nov, 2017 | Pubmed ID: 29115989
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.
Scientific reports Nov, 2017 | Pubmed ID: 29118344
Scaling behaviour and rate-determining steps in filamentous self-assembly.
Chemical science Oct, 2017 | Pubmed ID: 29147538
Inhibiting the Ca Influx Induced by Human CSF.
Cell reports Dec, 2017 | Pubmed ID: 29241555
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.
Science (New York, N.Y.) 12, 2017 | Pubmed ID: 29242346
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.
ACS chemical biology Mar, 2018 | Pubmed ID: 29300447
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.
Analytical chemistry Mar, 2018 | Pubmed ID: 29313342
Optical Structural Analysis of Individual α-Synuclein Oligomers.
Angewandte Chemie (International ed. in English) Apr, 2018 | Pubmed ID: 29342318
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.
Journal of the American Chemical Society 02, 2018 | Pubmed ID: 29357227
Biophotonics of Native Silk Fibrils.
Macromolecular bioscience Apr, 2018 | Pubmed ID: 29377575
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.
The Journal of biological chemistry Mar, 2018 | Pubmed ID: 29382725
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
Journal of neuroscience methods Aug, 2018 | Pubmed ID: 29452179
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
Annual review of physical chemistry 04, 2018 | Pubmed ID: 29490200
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.
Royal Society open science Feb, 2018 | Pubmed ID: 29515860
Microfluidic approaches for probing amyloid assembly and behaviour.
Lab on a chip 03, 2018 | Pubmed ID: 29527600
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.
Nature chemistry May, 2018 | Pubmed ID: 29581486
Molecular determinants of the interaction of EGCG with ordered and disordered proteins.
Biopolymers Aug, 2018 | Pubmed ID: 29603125
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.
Protein science : a publication of the Protein Society Jul, 2018 | Pubmed ID: 29603451
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.
Nature chemistry Jun, 2018 | Pubmed ID: 29736006
Cooperative Assembly of Hsp70 Subdomain Clusters.
Biochemistry Jul, 2018 | Pubmed ID: 29763298
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.
Chemical science Apr, 2018 | Pubmed ID: 29780480
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.
Cell reports Jun, 2018 | Pubmed ID: 29924993
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.
Chemical communications (Cambridge, England) Jul, 2018 | Pubmed ID: 29951679
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
ACS chemical biology Aug, 2018 | Pubmed ID: 29953201
Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.
ACS chemical neuroscience Aug, 2018 | Pubmed ID: 29986583
Structural differences between toxic and nontoxic HypF-N oligomers.
Chemical communications (Cambridge, England) Aug, 2018 | Pubmed ID: 30020284
Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.
Biochemistry Aug, 2018 | Pubmed ID: 30024736
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
Chembiochem : a European journal of chemical biology Oct, 2018 | Pubmed ID: 30051958
C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH.
Chemical science Jul, 2018 | Pubmed ID: 30061982
Obituary: Nico van Nuland 1961-2017.
European biophysics journal : EBJ Sep, 2018 | Pubmed ID: 30116857
Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model.
NPJ Parkinson's disease , 2018 | Pubmed ID: 30155513
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.
Nature communications Sep, 2018 | Pubmed ID: 30250131
SAR by kinetics for drug discovery in protein misfolding diseases.
Proceedings of the National Academy of Sciences of the United States of America 10, 2018 | Pubmed ID: 30257937
Statistical Mechanics of Globular Oligomer Formation by Protein Molecules.
The journal of physical chemistry. B Oct, 2018 | Pubmed ID: 30336667
Quantifying Co-Oligomer Formation by α-Synuclein.
ACS nano Nov, 2018 | Pubmed ID: 30371053
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
Nano letters Nov, 2018 | Pubmed ID: 30380895
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