Department of Microbiology,
Li Ka Shing Faculty of Medicine,
State Key Laboratory of Emerging Infectious Diseases,
Department of Microbiology, Li Ka Shing Faculty of Medicine
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Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity.
Science advances 06, 2021 | Pubmed ID: 34134991
SARS-related virus predating SARS outbreak, Hong Kong.
Emerging infectious diseases Feb, 2004 | Pubmed ID: 15030679
Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection.
Journal of hepatology Feb, 2007 | Pubmed ID: 17125879
A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.
Immunogenetics Jun, 2009 | Pubmed ID: 19488747
Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection.
Journal of hepatology Aug, 2009 | Pubmed ID: 19501422
Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population.
Journal of medical virology Mar, 2010 | Pubmed ID: 20087947
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.
Experimental biology and medicine (Maywood, N.J.) Aug, 2010 | Pubmed ID: 20660098
Krüppel-like factor 15 activates hepatitis B virus gene expression and replication.
Hepatology (Baltimore, Md.) Jul, 2011 | Pubmed ID: 21503941
A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection.
Cellular & molecular immunology Nov, 2011 | Pubmed ID: 21946434
A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection.
The Journal of infectious diseases Aug, 2012 | Pubmed ID: 22693232
Investigation of tumor suppressing function of CACNA2D3 in esophageal squamous cell carcinoma.
PloS one , 2013 | Pubmed ID: 23560067
Prioritizing genes responsible for host resistance to influenza using network approaches.
BMC genomics Nov, 2013 | Pubmed ID: 24261899
Surfactant protein B gene polymorphism is associated with severe influenza.
Chest Jun, 2014 | Pubmed ID: 24337193
Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma.
Gastroenterology Jun, 2014 | Pubmed ID: 24561231
Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.
Virology Apr, 2014 | Pubmed ID: 24725946
Liver grafts for transplantation from donors with diabetes: an analysis of the Scientific Registry of Transplant Recipients database.
PloS one , 2014 | Pubmed ID: 24847864
Requirement of CRTC1 coactivator for hepatitis B virus transcription.
Nucleic acids research Nov, 2014 | Pubmed ID: 25300488
Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9).
Scientific reports Feb, 2015 | Pubmed ID: 25687228
Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.
The Journal of infectious diseases Oct, 2015 | Pubmed ID: 25904605
Cross-protection of influenza A virus infection by a DNA aptamer targeting the PA endonuclease domain.
Antimicrobial agents and chemotherapy Jul, 2015 | Pubmed ID: 25918143
Receptor binding and transmission studies of H5N1 influenza virus in mammals.
Emerging microbes & infections Dec, 2013 | Pubmed ID: 26038448
Host genes and influenza pathogenesis in humans: an emerging paradigm.
Current opinion in virology Oct, 2015 | Pubmed ID: 26079652
Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset.
The Journal of infectious diseases Dec, 2015 | Pubmed ID: 26198719
Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets.
Journal of virology Oct, 2015 | Pubmed ID: 26202239
Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase.
Antiviral research Jan, 2016 | Pubmed ID: 26593979
PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs.
Scientific reports Nov, 2015 | Pubmed ID: 26612672
Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis.
Virology journal Dec, 2015 | Pubmed ID: 26690369
Quantification of Influenza Virus RNA in Aerosols in Patient Rooms.
PloS one , 2016 | Pubmed ID: 26849130
A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.
Scientific reports Feb, 2016 | Pubmed ID: 26911565
A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase.
Scientific reports Mar, 2016 | Pubmed ID: 26956222
Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern.
AIDS research and human retroviruses 09, 2016 | Pubmed ID: 27067022
A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication.
The Journal of antimicrobial chemotherapy 09, 2016 | Pubmed ID: 27272726
Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts.
Virology 11, 2016 | Pubmed ID: 27525812
MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.
Nature microbiology Feb, 2016 | Pubmed ID: 27572168
Isolation of H5N6, H7N9 and H9N2 avian influenza A viruses from air sampled at live poultry markets in China, 2014 and 2015.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin Sep, 2016 | Pubmed ID: 27608369
Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo.
ACS infectious diseases 07, 2016 | Pubmed ID: 27626099
Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface.
Antiviral research 01, 2017 | Pubmed ID: 27840201
Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus.
Scientific reports 11, 2016 | Pubmed ID: 27886255
PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammals.
Virology 01, 2017 | Pubmed ID: 27889648
Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.
Biochimica et biophysica acta. Gene regulatory mechanisms Apr, 2017 | Pubmed ID: 28242208
Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice.
Frontiers in immunology , 2017 | Pubmed ID: 28377769
Genetic analysis of H7N9 highly pathogenic avian influenza virus in Guangdong, China, 2016-2017.
The Journal of infection 01, 2018 | Pubmed ID: 28889968
Inhibitors of Influenza A Virus Polymerase.
ACS infectious diseases 03, 2018 | Pubmed ID: 29355011
Defining the sizes of airborne particles that mediate influenza transmission in ferrets.
Proceedings of the National Academy of Sciences of the United States of America 03, 2018 | Pubmed ID: 29463703
Assessing the risk of downwind spread of avian influenza virus via airborne particles from an urban wholesale poultry market.
Building and environment Jan, 2018 | Pubmed ID: 29479134
Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.
Emerging microbes & infections Mar, 2018 | Pubmed ID: 29593225
Differentiated human airway organoids to assess infectivity of emerging influenza virus.
Proceedings of the National Academy of Sciences of the United States of America 06, 2018 | Pubmed ID: 29891677
Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza.
Nature communications 06, 2018 | Pubmed ID: 29907765
Identification and characterization of GLDC as host susceptibility gene to severe influenza.
EMBO molecular medicine 01, 2019 | Pubmed ID: 30498026
Establishment of a lethal aged mouse model of human respiratory syncytial virus infection.
Antiviral research 01, 2019 | Pubmed ID: 30503888
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.
Nature communications 01, 2019 | Pubmed ID: 30631056
Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy.
International journal of molecular sciences Jan, 2019 | Pubmed ID: 30658479
A novel partial lid for mechanical defeatherers reduced aerosol dispersion during processing of avian influenza virus infected poultry.
PloS one , 2019 | Pubmed ID: 31067261
Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages.
The Journal of infectious diseases 02, 2020 | Pubmed ID: 31562757
Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 09, 2020 | Pubmed ID: 32270184
Targeting the Inositol-Requiring Enzyme-1 Pathway Efficiently Reverts Zika Virus-Induced Neurogenesis and Spermatogenesis Marker Perturbations.
ACS infectious diseases 07, 2020 | Pubmed ID: 32329611
Infection of bat and human intestinal organoids by SARS-CoV-2.
Nature medicine 07, 2020 | Pubmed ID: 32405028
Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.
The Journal of infectious diseases 08, 2020 | Pubmed ID: 32563187
Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 07, 2021 | Pubmed ID: 32649739
Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study.
The Lancet. Microbe May, 2020 | Pubmed ID: 32835326
Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target.
Science advances 08, 2020 | Pubmed ID: 32923629
Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters.
Cell reports. Medicine 10, 2020 | Pubmed ID: 32984855
SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19.
Cellular and molecular gastroenterology and hepatology , 2021 | Pubmed ID: 33010495
Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target.
Emerging microbes & infections Dec, 2020 | Pubmed ID: 33179566
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung.
Nature communications 01, 2021 | Pubmed ID: 33420022
Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses.
Biomedicines Jan, 2021 | Pubmed ID: 33477611
Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus.
Stem cell reports 03, 2021 | Pubmed ID: 33626333
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy Feb, 2021 | Pubmed ID: 33634751
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies.
Cell host & microbe 04, 2021 | Pubmed ID: 33657424
Development of cisplatin-loaded hydrogels for trans-portal vein chemoembolization in an orthotopic liver cancer mouse model.
Drug delivery Dec, 2021 | Pubmed ID: 33685316
STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells.
Emerging microbes & infections Dec, 2021 | Pubmed ID: 33979266
Monocytic MDSC mobilization promotes tumor recurrence after liver transplantation via CXCL10/TLR4/MMP14 signaling.
Cell death & disease 05, 2021 | Pubmed ID: 33990548
A(H1N1)pdm09 Influenza Viruses Replicating in Ferret Upper or Lower Respiratory Tract Differed in Onward Transmission Potential by Air.
The Journal of infectious diseases 01, 2022 | Pubmed ID: 34036370
Emerging SARS-CoV-2 variants expand species tropism to murines.
EBioMedicine Nov, 2021 | Pubmed ID: 34689086
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation.
EMBO molecular medicine 01, 2022 | Pubmed ID: 34826211
Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron.
Nature Jan, 2022 | Pubmed ID: 35062016
Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.
Pharmacological research Mar, 2022 | Pubmed ID: 35077844
A pan-sarbecovirus vaccine induces highly potent and durable neutralizing antibody responses in non-human primates against SARS-CoV-2 Omicron variant.
Cell research Feb, 2022 | Pubmed ID: 35210607
Circulating levels of periostin may help identify patients with more aggressive colorectal cancer.
International journal of oncology Mar, 2009 | Pubmed ID: 19212687
Causal inference with a quantitative exposure.
Statistical methods in medical research Feb, 2016 | Pubmed ID: 22729475
Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.
PloS one , 2012 | Pubmed ID: 23049772
Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population.
International journal of clinical and experimental pathology , 2014 | Pubmed ID: 25674271
Molecular design and structural optimization of potent peptide hydroxamate inhibitors to selectively target human ADAM metallopeptidase domain 17.
Computational biology and chemistry Apr, 2016 | Pubmed ID: 26709988
Safety and efficacy of sorafenib therapy in patients with hepatocellular carcinoma: final outcome from the Chinese patient subset of the GIDEON study.
Oncotarget Feb, 2016 | Pubmed ID: 26735891
Systemic delivery of IL-27 by an adeno-associated viral vector inhibits T cell-mediated colitis and induces multiple inhibitory pathways in T cells.
Journal of leukocyte biology Aug, 2016 | Pubmed ID: 27106672
mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile.
PloS one , 2016 | Pubmed ID: 27128484
Safety assessment of sorafenib in Chinese patients with unresectable hepatocellular carcinoma: subgroup analysis of the GIDEON study.
BMC cancer 03, 2018 | Pubmed ID: 29499662
Minimally invasive spinal anesthesia for cesarean section in maternal anticoagulation therapy: a randomized controlled trial.
BMC anesthesiology Jan, 2019 | Pubmed ID: 30636632
SUMOylation participates in induction of ischemic tolerance in mice.
Brain research bulletin Apr, 2019 | Pubmed ID: 30807794
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Nature genetics 04, 2019 | Pubmed ID: 30926973
Clinical characteristics of small bowel tumors diagnosed by double-balloon endoscopy: Experience from a Chinese tertiary hospital.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology Jan, 2020 | Pubmed ID: 32009611
Deciphering human macrophage development at single-cell resolution.
Nature Jun, 2020 | Pubmed ID: 32499656
Global Burden of Bacterial Skin Diseases: A Systematic Analysis Combined With Sociodemographic Index, 1990-2019.
Frontiers in medicine , 2022 | Pubmed ID: 35547219
Burden of tuberculosis and its association with socio-economic development status in 204 countries and territories, 1990-2019.
Frontiers in medicine , 2022 | Pubmed ID: 35935764
Efficacy and safety of remimazolam tosylate for sedation during upper gastrointestinal endoscopy: study protocol for a multicenter randomized controlled trial.
Trials Dec, 2022 | Pubmed ID: 36510290
The Effect of Exercise on Weight and Body Composition of Breast Cancer Patients Undergoing Chemotherapy: A Systematic Review.
Cancer nursing Jan, 2023 | Pubmed ID: 36728172
Weight management personas of breast cancer patients undergoing chemotherapy in China: a multi-method study.
BMC medical informatics and decision making Apr, 2024 | Pubmed ID: 38664653
Correction: Weight management personas of breast cancer patients undergoing chemotherapy in China: a multi-method study.
BMC medical informatics and decision making May, 2024 | Pubmed ID: 38773501
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