Magnus Stougaard

A new enzymatic route for production of long 5'-phosphorylated oligonucleotides using suicide cassettes and rolling circle DNA synthesis.

In situ detection of non-polyadenylated RNA molecules using Turtle Probes and target primed rolling circle PRINS.

Detection of short repeated genomic sequences on metaphase chromosomes using padlock probes and target primed rolling circle DNA synthesis.

Single-molecule detection of human topoisomerase I cleavage-ligation activity.

Multiplexed detection of site specific recombinase and DNA topoisomerase activities at the single molecule level.

Strategies for highly sensitive biomarker detection by Rolling Circle Amplification of signals from nucleic acid composed sensors.

Detection of single enzymatic events in rare or single cells using microfluidics.

Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level.

Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement.

DNA-based sensor for real-time measurement of the enzymatic activity of human topoisomerase I.

Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor.

DNA-based nanosensors for next-generation clinical diagnostics via detection of enzyme activity.

Topoisomerase I as a biomarker: detection of activity at the single molecule level.

Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I.

In-situ hybridization-based quantification of hTR: a possible biomarker in malignant melanoma.

The parental origin correlates with the karyotype of human embryos developing from tripronuclear zygotes.

Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations.

Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue.

Microfluidics-Enabled Enzyme Activity Measurement in Single Cells.

Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs.

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines.

Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons.

Novel DNA sensor system for highly sensitive and quantitative retrovirus detection using virus encoded integrase as a biomarker.

Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.

The Effects of Dithiothreitol on DNA.

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events.

Quantification of microRNA-21 and microRNA-125b in melanoma tissue.

On-slide detection of enzymatic activities in selected single cells.

Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5.

Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.

Telomerase reverse transcriptase promoter mutations and solar elastosis in cutaneous melanoma.

Detection of mRNA of Telomerase Protein in Benign Naevi and Melanomas Using RNAscope.

A new DNA sensor system for specific and quantitative detection of mycobacteria.

Rapid and Efficient Gene Deletion by CRISPR/Cas9.

Distinguishing recurrence and new primary tumor as well as the origin of neck metastases in head and neck cancer clinical trials by targeted DNA sequencing.

Intra-individual variation of circulating tumour DNA in lung cancer patients.

Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts.

Enzymatic activity in single cells.

Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study.

FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs.

Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities.

Targeted next generation sequencing panel for HPV genotyping in cervical cancer.

SNP-based detection of allelic imbalance: A novel approach for identifying KIAA1549-BRAF fusion in pilocytic astrocytoma using DNA sequencing.

Frequently used quantitative polymerase chain reaction-based methods overlook potential clinically relevant genetic alterations in epidermal growth factor receptor compared with next-generation sequencing: a retrospective clinical comparison of 1839 lung adenocarcinomas.

A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.

Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1.

TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.

A targeted expression panel for classification, gene fusion detection and PD-L1 measurements - Can molecular profiling replace immunohistochemistry in non-small cell lung cancer?

Targeted Next Generation Sequencing for Human Papillomavirus Genotyping in Cervical Liquid-Based Cytology Samples.

Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation.

The Diagnostic Value of Circulating Cell-Free HPV DNA in Plasma from Cervical Cancer Patients.

The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.

Impact of new molecular criteria on diagnosis and survival of adult glioma patients.

Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts.

Prognostic value of mutations, mutations and PD-L1 expression among lung adenocarcinomas treated with immunotherapy.