Massachusetts Eye and Ear

Back in 1905, in what is now the Czech Republic, Eduard Zirm performed the first corneal transplantation surgery (keratoplasty), which restored vision to a patient blinded by corneal injury. Today, eye banks all over the world prepare, store, and distribute donated corneas to hospitals so that thousands of sight-saving keratoplasties can be performed every year. In June 2012, JoVE has its eye on two research groups, one from Italy and the other from Michigan, who demonstrate two distinct methods for corneal graft preparation prior to transplantation.

Historically, JoVE, The Journal of Visualized Experiments, has focused primarily on biomedical research and has developed subsections for Bioengineering, Clinical and Translational Medicine, Immunology and Infection, and Neuroscience. This July, JoVE launches its Applied Physics section, which includes a range of content from Plasma Physics to Materials Science. We begin the new section with a notable article from Purdue University, where researchers in the Center for Laser-Based Manufacturing are studying.

Traditional microscopy requires lens objectives to magnify specimens, and can involve numerous optical components like additional objectives, filters, and mirrors to refract and direct light to optical sensors. The August 2012 issue of JoVE (Journal of Visualized Experiments) is marked by the third publication from the Ozcan Lab (University of California, Los Angeles) on their lens-free "on-chip" microscopy platform, which they have pioneered.

This September in JoVE, researchers from the School of Medicine at the Free University of Berlin demonstrate a novel method for studying how stroke patients compensate for visual field defects. To do this, our authors make use of a driving simulator complete with brakes, a steering wheel, and turn signals. Using driving simulation software and sophisticated eye tracking, researchers can compare the gaze behavior of stroke patients as they navigate through virtual driving courses with varying degrees of complexity. Though posterior cerebral artery infarction can lead to similar visual deficits in patients, some are able to navigate through the driving courses by developing compensatory eye movements, while others crash into dangerous obstacles, like wild boars. Through the analysis of compensatory gaze behavior employed by patients, our authors see great potential for using driving simulation as a tool to rehabilitate stroke patients trying to overcome the blind spots in their visual fields.

Here are some highlights from the October 2012 Issue of Journal of Visualized Experiments (JoVE).

In this issue, Oestreicher et al. show us how to isolate magnetotactic bacteria from freshwater samples, and concentrate the bacteria at one end of a glass capillary. The magnetotactic bacteria can then be visualized by light and transmission electron microscopy, and used for various other assays.

Here are some highlights from the December 2012 Issue of Journal of Visualized Experiments (JoVE).

Here's a look at some of the milestones and highlights of the year 2012 in Journal of Visualized Experiments (JoVE).

Here's a look at what's coming up in the February 2013 Issue of Journal of Visualized Experiments (JoVE).

Here are some highlights from the March 2013 issue of Journal of Visualized Experiments (JoVE).

Here are some highlights from the April 2013 Issue of Journal of Visualized Experiments (JoVE).

Here are some highlights from the May 2013 Issue of Journal of Visualized Experiments (JoVE).

Here are some highlights from the June 2013 Issue of Journal of Visualized Experiments (JoVE).

Here are some highlights from the July 2013 Issue of Journal of Visualized Experiments (JoVE).

January 2015: This Month in JoVE - Introducing JoVE Developmental Biology

February 2015: This Month in JoVE - Tracking Down Foodborne Illness, Imaging Baby Brains, and Paying Scientific Attention to Attention

March 2015: This Month in JoVE - Solving Crime with Science, Applying Technology to Understand Trees, and Studying Protein Synthesis on a Chip

April 2015: This Month in JoVE - Studying Locomotion in Drunken Worms, Preserving Human Liver for Transplantation, and Visualizing Bacterial Swarms

This Month in JoVE - Assessing Freezing Tolerance in Plants, Patterning 2D Shapes with DNA, Studying Ischemia In Vitro, Studying Social Cognition in Monkeys

June 2015: This Month in JoVE - Celebrating JoVE's 100th Issue

July 2015 - This Month in JoVE: Treating Canine Halitosis, Minimizing Workplace Stress, and Assessing Electrical Activity and Herbicide Resistance in Plants

August 2015 - This Month in JoVE: Isolating Stem Cells, Bioengineering the Kidney, and Getting Kids to eat Carrots

September 2015 - This Month in JoVE: Measuring Greenhouse Gases and Herbicide Resistance, Bioengineering Bone, and Analyzing Neuromuscular Control with Virtual Reality

October 2015 - This Month in JoVE: tuberculosis infection modeling, telemetric temperature pills, bioengineered cartilage, and 3D neuronal networks

November 2015 - This Month in JoVE: Drosophila Social Space, Structured Rehabilitation for Multifunctional Prosthetics, and Thermal Imaging in Wild Birds

December 2015 - This Month in JoVE: Flu Surveillance in Swine, DNA Nanorobots, Analyzing Crude Oil, and a Translational Model of Depression

JoVE - Year in Review: 2015

February 2016 - This Month in JoVE: Photoconvertible Proteins, Gold Nanoparticles, PET Principles, and Bone Marrow Microenvironments

March 2016 - This Month in JoVE: RNA interference in Mosquitoes, iPSCs Derived from Nasal Epithelia, Air Sampling of Atmospheric Aerosols, and Autologous Micro-grafts for Skin Lesions

April 2016 - This Month in JoVE: Cell Migration, Bacterial Motility, Psycholinguistics, and In Vitro Eye Model for Contact Lenses

May 2016 - This Month in JoVE: Cheetah footprints, lens stiffness, and digitally printed solar cells

June 2016 - This Month in JoVE: Blueberry Analysis, Impact Testing Football Helmets, Stencil Micropatterning of Stem Cells, and a Test for Soil Plasticity

July 2016: This Month in JoVE

September 2016-This Month in JoVE: Introducing JoVE Genetics, JoVE Biochemistry, and JoVE Cancer Research

The goal of this protocol is to demonstrate the preparation, culture, treatment, and immunostaining of neonatal murine cochlear explants. The technique can be utilized as an in vitro screening tool in hearing research.

The goal of this protocol is to outline the collection and processing of human surgical samples for multiple downstream applications in vestibular schwannoma and Schwann cell research.