In Vitro Induction of Normoxia and Hypoxia/reoxygenation
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Results: Anti-oxidant Effect of Melatonin in Syncytiotrophoblast Exposed to Hypoxia/reoxygenation
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Conclusion
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The overall goal of this procedure is to study the protective effects of melatonin using immuno-purified primary human villous cytotrophoblast cells, cultured under hypoxia or reoxygenation. This method can help to understand the mechanisms and si
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This manuscript presents a unique in vitro model of immunopurified human villous cytotrophoblast cells cultured under hypoxia/reoxygenation. This model is suitable to study the protective effects of promising treatments, such as melatonin, on pregnancy complications associated with increased oxidative stress and altered placental function.