Intranasal Liposome Administration and Lung Metastasis Evaluation
3:20
Alveolar Macrophage Flow Cytometric Analysis
6:08
Results: Representative Tumor Growth and Metastatic Lung Burden Assessment and Analysis
7:15
Conclusion
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The overall goal of these experiments is to determine to role of pulmonary alveolar macrophages in cancer metastasis using a syngenaic model of breast cancer. This method can answer some of the key questions in tumor immunology and cancer metastas
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Here we describe the model and approach to study functions of pulmonary alveolar macrophages in cancer metastasis. To demonstrate the role of these cells in metastasis, the syngeneic (4T1) model of breast cancer in conjunction with the depletion of alveolar macrophage with clodronate liposomes was used.