Orthotopic Ewing Sarcoma (ES) Cell Injection and Hypoxia Induction by Femoral Artery Ligation (FAL)
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Primary Tumor Excision by Leg Amputation
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Metastasis Monitoring and Primary Tumor Cell Culture
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Results: Representative Effects of FAL on Primary Tumor Growth
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Conclusion
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The overall goal of this procedure is to directly test the effect of tumor hypoxia on metastasis using an animal model. This method can help to identify the mechanism underlying the prometastatic effects of hypoxia and potential novel therapeutic
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This manuscript describes the development of an animal model that allows for the direct testing of the effects of tumor hypoxia on metastasis and the deciphering the mechanisms of its action. Although the experiments described here focus on Ewing sarcoma, a similar approach can be applied to other tumor types.