Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
Generation of Targeted Therapy Resistant Subclones
4:03
Restoring Target-therapy Inhibitor Sensitivity by Candidate R-gene Knock-down
6:31
Results: Drug Resistant Subclone Generation and Sensitivity Restoration
8:01
Conclusion
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The overall goal of this preclinical platform is to provide a standard procedure to identify and characterize the mechanisms driving acquired resistance to targeted therapies. This method can help to implement genome drive in oncology, in particul
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This is a time- and cost-effective in vitro protocol investigating the mechanisms of acquired resistance to targeted therapeutic agents, which is a highly unmet medical need in cancer management.