Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

DOI :

10.3791/59976-v

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August 13th, 2019

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7,936 Views

Laurine Marger¹, Antonio Barone², Carla P. Martinelli-Kläy³, Leandra Schaub¹, Malin Strasding⁴, Mustapha Mekki¹, Irena Sailer⁴, Susanne S Scherrer¹, Stéphane Durual¹

¹Division of Fixed Prosthodontics and Biomaterials, Biomaterials Laboratory, University of Geneva, University Clinic of Dental Medicine, ²Department of Surgery, Division of Oral and Maxillofacial Surgery (HUG), Unity of Oral Surgery and Implantology, University of Geneva, University Clinic of Dental Medicine, ³Department of Surgery, Division of Oral and Maxillofacial surgery (HUG), Laboratory of Oral & Maxillofacial Pathology, University of Geneva, University Clinic of Dental Medicine, ⁴Division of Fixed Prosthodontics and Biomaterials, University of Geneva, University Clinic of Dental Medicine

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Here we present a surgical protocol in rabbits with the aim to assess bone substitution materials in terms of bone regeneration capacities. By using PEEK cylinders fixed onto rabbit skulls, osteoconduction, osteoinduction, osteogenesis and vasculogenesis induced by the materials may be evaluated either on live or euthanized animals.