Michael V. Sofroniew

Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.

The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP.

The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells.

Reactive astrocytes protect tissue and preserve function after spinal cord injury.

GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain.

Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.

Reactive astrocytes in neural repair and protection.

Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes.

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus.

Paradoxical influence of hippocampal neurogenesis on working memory.

Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione.

Starring roles for astroglia in barrier pathologies of gut and brain.

Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury.

Glia get excited.

Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration.

Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons.

STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury.

Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.

Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system.

Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS.

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.

Molecular dissection of reactive astrogliosis and glial scar formation.

PTEN dosage is essential for neurofibroma development and malignant transformation.

Astrocytes: biology and pathology.

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes.

Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination.

Reactive astrocytes as therapeutic targets for CNS disorders.

Adenomatous polyposis coli is essential for both neuronal differentiation and maintenance of adult neural stem cells in subventricular zone and hippocampus.

Neuromyelitis optica: circulating autoantibodies provoke astrocyte-mediated neural dysfunction.

Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons.

Neuroprotection mediated through estrogen receptor-alpha in astrocytes.

Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration.

Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types.

Neurological diseases as primary gliopathies: a reassessment of neurocentrism.

Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories.

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.

STAT3-mediated astrogliosis protects myelin development in neonatal brain injury.

Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots.

Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses.

Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons.

Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury.

Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators.

Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system.

Heterogeneity of reactive astrocytes.

Reactive gliosis and the multicellular response to CNS damage and disease.

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.

Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone.

Astrocytes and Huntington's disease.

Memantine enhances recovery from stroke.

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis.

Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity.

Astrogliosis.