Baljit S. Khakh

Control of P2X(2) channel permeability by the cytosolic domain.

ATP modulation of excitatory synapses onto interneurons.

ATP-gated P2X channels.

Contribution of calcium ions to P2X channel responses.

ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks.

Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions.

Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamics.

An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy.

P2X receptors as cell-surface ATP sensors in health and disease.

Two forms of single-vesicle astrocyte exocytosis imaged with total internal reflection fluorescence microscopy.

Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes.

Tracking transmitter-gated P2X cation channel activation in vitro and in vivo.

Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons.

ATP-gated P2X receptors on excitatory nerve terminals onto interneurons initiate a form of asynchronous glutamate release.

Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy.

ATP-gated P2X cation-channels.

Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels.

Tunable calcium current through TRPV1 receptor channels.

Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1.

The double life of ATP.

Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.

P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes.

Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters.

Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps.

Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).

Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated.

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.

Allosteric modulation of Ca2+ flux in a ligand-gated cation channel (P2X4) by actions on lateral portals.

Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK.

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging.

Neuromodulation by extracellular ATP and P2X receptors in the CNS.

Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.

Genetically encoded calcium indicators and astrocyte calcium microdomains.

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses.

ATP-gated ion channels mediate adaptation to elevated sound levels.

TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.

Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system.

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.

Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.

Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway.

Astrocytes and Huntington's disease.

Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin.

Slow neuromodulation mediated by ATP P2X receptors.

ATP-gated P2X receptors in health and disease.

Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo.

Diversity of astrocyte functions and phenotypes in neural circuits.

Probing the Complexities of Astrocyte Calcium Signaling.

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice.

Astrocyte scar formation aids central nervous system axon regeneration.

P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo.

Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.

Active role of capillary pericytes during stimulation-induced activity and spreading depolarization.

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.

Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.

The Emerging Nature of Astrocyte Diversity.

Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function.